Biomedical Application of Nanoparticles

Dr. Kyung A. Kang, Chemical Engineering, University of Louisville
When Sep 11, 2015
from 01:00 PM to 02:00 PM
Where Ernst Hall, Room 310
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Abstract

Nano-sized particles have properties that are not in their bulk form but are highly beneficial for biomedical application. They are small enough to be integrated in a molecular or cellular level, fixing problems more in a fundamental level, but big enough to increase the cellular uptake rate and body blood circulation time. Here, a few examples that are studied in our team are presented.

  1. Fluorophores have been used as signal mediators in biosensing/imaging. Gold nanoparticles (GNP) form electromagnetic (plasmon) field on their surface by photonic energy. When a fluorophore is placed in the field, its electrons are affected by the plasmon and its fluorescence can be altered from complete quenching to extensive enhancement. Utilizing this relationship we are developing highly sensitive and specific optical contrast agents for cancer detection.
  2. Alternating electromagnetic (AEM) field at an appropriate frequency can heat super paramagnetic nanoparticles. Using this phenomenon, iron oxide nanoparticles (IONP) are studied for cancer hyperthermia. The heating performance of IONPs with respect to the particle sizes, density of the media, and configuration of AEM field applicator are presented.
  3. Pluronic F-127 (PF127) is a biocompatible polymer that possesses both temperature and concentration-dependent gelation properties. We have combined IONPs and PF127 to develop both tumor-specific hyperthermia and long-term, sustained drug delivery.
  4. Primo Vascular System (PVS) is a newly found vascular system. The PVS has been shown to regenerate tissues and blood cells, and appears to have a role in cancer metastasis. PVS, however, is very small and optically translucent and therefore, is difficult to identify. We have utilized hollow gold nanospheres with a proper property to identify the PVS more effectively.

Speaker's Biography

Dr. Kyung A. Kang is a professor of Chemical Engineering at the J.B. Speed School of Engineering.