SEMINAR: Myocardial Infarction: Diagnosing the Cause

Andrew Filippis, M.D.
When Mar 21, 2018
from 12:00 PM to 01:30 PM
Where Shumaker Bldg, Rm 139
Contact Name
Contact Phone 502-852-7485
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Abstract: Acute myocardial infarction (MI) is complex, and a variety of pathologies can result in this clinical diagnosis. Current guidelines recognize two classes of MI: thrombotic (Type 1) and non-thrombotic (Type 2) MI, which have similar prevalence but require different treatment. Unfortunately, diagnostic criteria for differentiating between the two do not exist. This results in inefficient and suboptimal care of patients suspected of MI. For example, an increase in circulating troponin levels, the most sensitive and specific diagnostic test for MI, reports myocardial necrosis, the final step in the process—not the etiological cause and antecedent therapeutic target. Hence, the overall goal of our Laboratory is to develop diagnostic criteria to identify and distinguish thrombotic and non-thrombotic MI in order to allow for etiology driven diagnosis and treatment of specific sub-types of acute MI.

Speaker: Dr. Andrew DeFilippis is Associate Professor of Medicine and Director of Cardiovascular Disease Prevention. He completed medical training at Georgetown University, Emory University, and Johns Hopkins University before joining UofL. In addition to his clinical work in Cardiology, his research interests include biomarker development for acute myocardial infarction, cardiovascular risk prediction, plaque disruption/coronary thrombosis, and Omics. He has received NIH funding to support his work.

YouTube Video of the seminar