SEMINAR: “Healing-Responsive” Materials for Engineering Comprehensive Tissue Regeneration

Dr. John Martin
When Mar 27, 2019
from 12:00 PM to 01:30 PM
Where Vogt Bldg, Rm 311
Contact Name
Contact Phone 502-852-7485
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Abstract: Regenerative medicine relies on both implantable, biodegradable scaffolds to guide new tissue growth and local delivery of therapeutics to encourage cellular migration and tissue development. However, current regenerative technologies have poorly controlled drug delivery kinetics and utilize scaffold materials whose resorption rates do not match the pace of new tissue formation. Consequently, there remains a need for regenerative medicine platforms that can selectively release therapeutics and biodegrade in response to a localized, cell-specific healing response. We have developed a number of synthetic polymer modalities that selectively degrade in response to cell-generated signals, most notably poly (thioketal) (PTK) polymers that are sensitive to reactive oxygen species (ROS). These “healing-responsive” materials have been applied to create 1) selectively cell-degradable scaffolds that enhance tissue regeneration in impaired skin wounds, and 2) nanoscale material coatings that selectively release encapsulated drug payloads in response to localized cellular triggers in craniofacial bone defects. Fabricated PTK-based scaffolds underwent ROS-dependent degradation both in vitro and in vivo while promoting tissue regeneration in impaired wounds, whereas ROS-degradable PTK hydrogels showed promise as vehicles for minimally-invasive stem cell encapsulation and delivery. Similarly, electrostatic multilayer films constructed with PTK polycations have demonstrated selective ROS-mediated growth factor release of bone morphogenic protein-2 (BMP-2) and promoted cellular osteogenesis levels corresponding with drug release kinetics. Overall, the development of ROS-degradable polymers for tissue engineering technologies represents an exciting new advance in environmentally-responsive materials and offers a highly translatable biomaterial platform for a number of clinical applications.

Speaker: Dr. John Martin is currently a Postdoctoral Fellow at the Massachusetts Institute of Technology (MIT) under the direction of Prof. Paula Hammond in the Department of Chemical Engineering. He obtained his PhD in Biomedical Engineering in the lab of Prof. Craig Duvall at Vanderbilt University in 2016, and graduated with his B.S. in Biosystems Engineering from the University of Kentucky in 2011. Dr. Martin’s research interfaces at the disciplines of biomaterials, regenerative medicine, and drug delivery by developing technologies that specifically respond to cell-generated stimuli generated during the body’s natural healing process. During his research career, he has authored numerous peer-reviewed publications, earned multiple research presentation honors, and was recently awarded the NIH Ruth L. Kirschstein (F32) Postdoctoral Research Fellowship in 2018. 

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