SEMINAR: Metabolic Regulation of Vascular Ion Channel Activity

Dr. Matthew Nystoriak
When Nov 16, 2017
from 12:00 PM to 01:30 PM
Where Shumaker Research Bldg, RM 139
Contact Name
Contact Phone 852-7485
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Abstract:  Blood flow depends largely upon the diameter of small arteries and arterioles, which is controlled by the contractile state of smooth muscle (VSM) lining the vascular wall. VSM contractility is determined by membrane potential and the degree of calcium influx via Ltype voltage-dependent calcium channels in the sarcolemma. A variety of ion channels involved in the regulation of VSM contractility respond to metabolic cues in order to finetune vascular tone and couple blood flow with energetic demands of the local tissue environment. This talk will focus on the use of patch clamp electrophysiology, myography, and advanced cellular imaging to evaluate ion channel function in the vasculature to improve understanding of how ion channel proteins are functionally regulated by metabolic signals in an effort to reveal novel targets for treatment of cardiovascular disease associated with aberrant regulation of vascular tone.

Speaker:Dr. Matthew Nystoriak is an Assistant Professor of Medicine, Division of Cardiovascular Medicine, and member of the Diabetes and Obesity Center at the University of Louisville. He graduated (PhD) from the Department of Pharmacology at the University of Vermont, College of Medicine, and completed his postdoctoral training in Physiology and Biophysics at the University of Washington in Seattle, and Pharmacology at the University of California, Davis where he gained experience in electrophysiological and cellular imaging techniques related to the study of vascular function and regulation of blood flow in health and disease.

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