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You are here: Home → For Faculty & Staff → Reference Search → 2005 References → Culligan et al, Jul 2005, A randomized controlled trial comparing fascia lata and synthetic mesh for sacral colpopexy

Culligan et al, Jul 2005, A randomized controlled trial comparing fascia lata and synthetic mesh for sacral colpopexy

Reference

Culligan, P. J., Blackwell, L., Goldsmith, L. J., Graham, C. A., Rogers, A., & Heit, M. H.  A randomized controlled trial comparing fascia lata and synthetic mesh for sacral colpopexy. Obstetrics & Gynecology, 106(1): 29-37. (Professional Student Author(s): Rogers,A.) (2005).

Abstract

OBJECTIVE: To compare the objective anatomic outcomes after sacral colpopexy performed with cadaveric fascia lata and polypropylene mesh. METHODS: Patients undergoing a sacral colpopexy were randomized to receive either fascia lata or polypropylene mesh in a double-blinded fashion. Data were collected at 6 weeks, 3 months, 6 months, and 1 year postoperatively. The main outcome measures were pelvic organ prolapse quantification (POP-Q) system stage and individual POP-Q points over time. Objective anatomic failure was defined as POP-Q stage 2 or more at any point during the follow-up period. Proportions of patients with objective anatomic failure at 1 year in each group were compared using the chi(2) test. Mean POP-Q points and stage at 1 year were compared by using the independent samples t test. RESULTS: One hundred patients were randomized to receive either fascia (n = 46) or mesh (n = 54). Of the 89 patients returning for 1-year follow-up, 91% (41/45) of the mesh group and 68% (30/44) of the fascia group were classified as objectively cured (P = .007). We found significant differences between the mesh and fascia groups with respect to the 1-year postoperative comparisons of points Aa, C, and POP-Q stage. There were no differences between the 2 groups with respect to points TVL (total vaginal length), GH (genital hiatus), PB (perineal body), Ap or Bp (2 points along the posterior vaginal wall). CONCLUSIONS: Polypropylene mesh was superior to fascia lata in terms of POP-Q points, POP-Q stage, and objective anatomic failure rates. LEVEL OF EVIDENCE: I
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