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Compton et al, 2005, Fatal fluoxetine ingestion with postmortem blood concentrations

Reference

Compton, R., Spiller, H. A., & Bosse, G. M.  Fatal fluoxetine ingestion with postmortem blood concentrations. Journal of Toxicology - Clinical Toxicology, 43(4): 277-279. (2005).

Abstract

A 37-year-old male ingested 12 gm of fluoxetine approximately 2 hours prior to arrival at an emergency department. The patient developed tonic-clonic seizures, which resolved with diazepam and midazolam therapy. The patient then developed profound bradycardia that progressed to ventricular fibrillation and asystole. A postmortem toxicology analysis reported a fluoxetine concentration of 4500 mcg/L and diazepam of 500 mcg/L. No other drugs were detected. We report an unusual case of massive fluoxetine ingestion resulting in neurological and cardiovascular toxicity resulting in death
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