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William D. Ehringer, Ph.D.

by Denise Hughes — last modified May 15, 2008 10:45 AM

William Ehringer










WILLIAM D. EHRINGER, Ph.D.
wdehri01@louisville.edu
Associate Professor
Indiana University, 1993

The goal of my research is to understand and identify how high energy phosphates can be used during periods of 1) normal oxygen tension, 2) low oxygen tension and 3) decreased blood flow. It is well-known that the chemical bond energy of the high energy phosphates is responsible for nearly every aspect of cellular existence. By developing and utilizing unique vectors to transport the high energy phosphates across the plasma membrane of cells, we have developed a system that can maintain cellular energy supplies. This high energy delivery system allows cells, tissues, organs, and organisms to maintain viability and function during periods of hypoxia or ischemia. Currently, my lab uses our ATP delivery system in wound healing (diabetic, acute, and burn), hemorrhagic shock, chemical hypoxia (cyanide poisoning), bacterial growth, organ transplantation, tissue preservation, and cell preservation.

My lab is a highly collaborative, multi-disciplinary entity that conducts experiments at the molecular, cellular, and animal level. Using the information gathered in each area, we are able to create a more broad understanding of how high energy phosphate delivery can be maximized for each application. One version of ATP delivery system is the subject of two different upcoming human clinical trails, one in wound healing the other in kidney preservation.

Selected Peer-Reviewed Publications:

  1. Ehringer, W.D., Chiang, B., and Chien, S. 2001. The Uptake and Metabolism of Fructose-1,6-diphosphate in Rat Cardiomyocytes. Molecular and Cellular Biochemistry, 221:33-40.
  2. Ehringer, W.D., Chiang, B., Su, S., Stillwell, W., and Chien, S. 2002. Destabilizing Effects of Fructose-1,6-diphosphate On Membrane Bilayers. Lipids, 37: 885-892.
  3. Calamita, H.G., Ehringer, W.D., and R.J. Doyle. 2002. Evidence That The Cell Wall Of Bacillus subtillis Is Protonated During Respiration. Proceedings of the National Academy of Sciences U.S.A., 98:15260-15263.
  4. Cleary DB. Ehringer WD. Maurer MC. 2003. Establishing the inhibitory effects of bradykinin on thrombin. Archives of Biochemistry & Biophysics. 410(1):96-106.
  5. Zakaria, R., Ehringer, W.D., Tsakadze, N., Li, N., and Garrison, N. 2005. Direct Energy Delivery Improves Tissue Perfusion after Resuscitated Shock. Surgery, 138: 195-203.
  6. Ehringer, W.D., Chiang, B. , Maldonado, C., Thomas, C., Essick, C., Cerrito, P., Arteel, G., Anderson, G., Stillwell, W., and Chien, S. “ATP Delivery via Fusogenic Lipid Vesicles”, Proceedings of the National Academy of Sciences. To Be Submitted, 2006.
  7. Wang, J., Miller, J., Ehringer, W., Guo, S., Reeves, S., Skikic, M., Gozal, D., Wang, Y. VitaSol (lipid-packaged ATP) protects rats against hypoxic injury. To be submitted 2006.
  8. Chien, S., Anderson, G., Chiang, B., Murphree, S., Essick, E., Hauck, M., Li, M., and Ehringer, W.D. Enhancing Skin Wound Healing with a New Intracellular ATP Delivery System. American Journal of Surgery. 193(2):213-8, 2007.
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