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Srinivas D. Sithu, Ph.D.

by Hughes,Denise C — last modified Aug 25, 2010 10:51 AM

sithu

srinivas.sithu@louisville.edu
Assistant Professor
University of Lucknow, India, 1999

 

Research:
Coronary heart disease is caused by atherosclerosis, the narrowing of the coronary arteries due to fatty build ups of plaque. It is important to understand the molecular mechanisms of inflammatory disease process in order to inhibit progression of atherosclerosis. I was working in the past to elucidate mechanisms that mediate cellular adhesive interactions that may lead to blood vessel obstruction. Specifically, I was studying the mechanisms mediating processing and shedding of cell adhesion molecule, ICAM-1 which may regulate the inflammatory process of leukocyte migration to sites of injury. Currently, building on my foundational studies, I have expanded my research area to delineate the molecular and cellular mechanisms by which environmental pollutants exacerbate atherosclerosis and promote thrombosis. In my ongoing research projects, I study (1) acrolein, a toxicant aldehyde high in wood, tobacco smoke, automobile exhaust and industrial wastes and (2) arsenic, a ground water pollutant in many parts of the world.

Publications:

  1. Srinivas D. Sithu, Sanjay Srivastava, Maqsood A. Siddiqui, Daniel J. Conklin, Petra Haberzettl, Tim O’Toole, Aruni Bhatnagar and Stanley E. D’Souza. Exposure of Acrolein by Inhalation causes Platelet Activation. Toxicol. Appl. Pharmacol. (in press; doi:10.1016/j.taap.2010.07.013). http://www.ncbi.nlm.nih.gov/pubmed/20678513
  2. Han S, Arnold SA, Sithu SD, Mahoney ET, Geralds JT, Tran P, Benton RL, Maddie MA, D'Souza SE, Whittemore SR, Hagg T. (2010) Rescuing vasculature with intravenous angiopoietin-1 and alphavbeta3 integrin peptide is protective after spinal cord injury. Brain, 133(4):1026-42. http://www.ncbi.nlm.nih.gov/pubmed/20375135
  3. Srivastava S, Vladykovskaya EN, Haberzettl P, Sithu SD, D'Souza SE, States JC. (2009) Arsenic exacerbates atherosclerotic lesion formation and inflammation in ApoE-/- mice. Toxicol Appl Pharmacol. 241(1):90-100. http://www.ncbi.nlm.nih.gov/pubmed/19682479
  4. Nakashima S, Arnold SA, Mahoney ET, Sithu SD, Zhang YP, D'Souza SE, Shields CB, Hagg T. (2008) Small-molecule protein tyrosine phosphatase inhibition as a neuroprotective treatment after spinal cord injury in adult rats. J Neurosci. 28(29):7293-303. http://www.ncbi.nlm.nih.gov/pubmed/18632933
  5. Essick E, Sithu SD, Dean W, D'Souza S. (2008) Pervanadate-induced shedding of the intercellular adhesion molecule (ICAM)-1 ectodomain is mediated by membrane type-1 matrix metalloproteinase (MT1-MMP). Mol Cell Biochem. 314(1-2):151-9. http://www.ncbi.nlm.nih.gov/pubmed/18454303
  6. Moshal KS, Zeldin DC, Sithu SD, Sen U, Tyagi N, Kumar M, Hughes WM Jr, Metreveli N, Rosenberger DS, Singh M, Vacek TP, Rodriguez WE, Ayotunde A, Tyagi SC. (2008) Cytochrome P450 (CYP) 2J2 gene transfection attenuates MMP-9 via inhibition of NF-kappabeta in hyperhomocysteinemia. J Cell Physiol. 215(3):771-81. http://www.ncbi.nlm.nih.gov/pubmed/18181170
  7. Sithu SD, English WR, Olson P, Krubasik D, Baker AH, Murphy G, D'Souza SE. (2007) Membrane-type 1-matrix metalloproteinase regulates intracellular adhesion molecule-1 (ICAM-1)-mediated monocyte transmigration. J. Biol. Chem. 282(34):25010-9. http://www.ncbi.nlm.nih.gov/pubmed/17591781
  8. Tsakadze NL*, Sithu SD*, Sen U, English WR, Murphy G, D'Souza SE. (2006) Tumor Necrosis Factor- Converting Enzyme (TACE/ADAM-17) Mediates the Ectodomain cleavage of Intercellular Adhesion Molecule (ICAM-1) J Biol. Chem. 281(6):3157-64. (*equal contribution). http://www.ncbi.nlm.nih.gov/pubmed/16332693
  9. Tsakadze NL, Sen U, Zhao Z, Sithu SD, English WR, D'Souza SE. (2004) Signals mediating cleavage of intercellular adhesion molecule-1. Am. J. Physiol. Cell Physiol. 287(1):C55-63. http://www.ncbi.nlm.nih.gov/pubmed/14973144

 

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