John T. Fleming, Ph.D.
JOHN T. FLEMING, Ph.D.
University of Georgia, 1980
The primary goal of my research is to identify the physiologic mechanisms which regulate the function of microscopic blood vessels. One project area addresses the high incidence of kidney failure among diabetic patients. The research seeks to identify the role of insulin to regulate the constrictor function of kidney arterioles. The second focus area is the regulation of blood flow to bone. The research addresses important orthopaedic problems such as osteoporosis, delayed fracture healing and smoking-related orthopaedic complications by assessing changes in bone arteriolar function associated with aging and nicotine consumption.
- Fleming, J.T., Michelle T. Barati, Dennis J. Beck, James C. Dodds, Arthur Malkani, Dushi Paramesaran, Galia K. Soukhova, Michael J. Voor and Jeremy B.A. Feitelson. Bone blood flow and vascular reactivity. Cells, Tissues, Organs 169 (3), 2001.
- Feitelson, J.B.A., E. Kulenovic, D.J. Beck, P.D. Harris, J.C. Passmore, A.L. Malkani, and J.T. Fleming. Endogenous norepinephrine regulates blood flow to the intact rat tibia. J. Orthopaedic Research 20:391-396, 2002.
- Feitelson, J.B.A., P.P. Rowell, C.S. Roberts, and J.T. Fleming. Two week nicotine treatment selectively increases bone vascular constriction in response to norepinephrine. J Orthopaedic research 21:497-502, 2003.
- Soukhova-O’Hare, G., Lei, Z., Falcone, J.,C., Barati,M.T., Feitelson, B.A., Rao, Ch.V., and Fleming, J.T. Bone medullary arterioles from ovariectomized rats have smaller baseline diameters but normal eNOS and NO-mediated dilation. Life Sciences 77 (15): 1899-1912, 2005.
- Fleming, J.T Stephen A. Lobo; Chandler H. Park; Sharon A. Gordon; Craig S. Roberts, and Peter P. Rowell. Nicotine Does Not Reduce Blood Flow to Health Bone in Rats. The Amer. J. Orthopedics, In Press, 2007.