Physiology & Biophysics

Frederick N. Miller, Ph.D.
fnmill01@louisville.edu
Professor Emeritus
University of Cincinnati, 1971

The goal of our research is to determine of the physiological and pathological mechanisms of the microcirculation during inflammatory responses. In vivo fluorescent microscopy is used with a closed circuit television system, image digitization, and a computerized image analysis system to identify protein movement, changes in tissue blood flow, platelet thrombus formation, and white blood cell activation. With this system, we have studied changes due to topical or systemic drugs, diseases such as cancer and hypertension, and the allergic or immune response. In vivo studies are complimented with cell cellular studies which elucidate inflammatory responses of the endothelium.

Publications

1. Schuschke, D.A., J.T. Saari and F.N. Miller. Leukocyte-endothelial adhesion is impaired in the cremaster muscle microcirculation of the copper-deficient rat. Immunology Letters 76(2):139-144, 2001.
2. Wang, W-Z, S.Z. Guo, G.L. Anderson, and F.N. Miller. The initiating factors of late preconditioning in skeletal muscle. Journal of Surgical Research 99:92-99, 2001.
3. Wang, W.Z., L.L. Stepheson, G.L. Anderson, F.N. Miller, K.T. Khiabani and W.A. Zamboni. Role of PKC in microvascular protection induced by late preconditioning. Journal of Surgical Research 106(1):166-172, 2002.
4. Turina, M., F.N. Miller, P. McHugh, W.G. Cheadle, H.C. Polk Jr. Endotoxin inhibits apoptosis but induces primary necrosis in neutrophils. Inflammation 29(1):55-63, 2006.
5. Turina, M., F.N. Miller, C. Tucker, H.C. Polk Jr. The effects of hyperglycemia, hyperinsulinemia, and hyperosmolarity on neutrophil apoptosis. Surgical Infections (Larchmt) 7(2):111-21, 2006.
6. Turina, M., F.N. Miller, C. Tucker, H.C. Polk. Short-term hHyperglycemia in surgical patients and a study of related cellular mechanisms. Journal of Annals of Surgery 243(6):845-851, 2006.