Physiology & Biophysics

DALE A. SCHUSCHKE, Ph.D.
daschu01@louisville.edu
Professor
North Dakota, 1987

The primary focus of the lab is on the role of copper nutrition in microvascular control mechanisms. We use both in vivo and in vitro techniques to study inflammatory processes including macromolecular leakage, platelet thrombus formation, vasoreactivity and leukocyte-endothelial cell interactions. This work has received national recognition from the American Society of Nutritional Sciences in the form of its BioServe Award for Experimental Animal Nutrition.


SELECTED PUBLICATIONS:

1. Schuschke, D.A., J.C. Falcone, J.T. Saari, J.T. Fleming, S.S. Percival, S.A. Young, J.M. Pass and F.N. Miller. Endothelial cell calcium mobilization to acetylcholine is attenuated in copper-deficient rats. Endothelium 7: 83-92, 2000.
2. Schuschke, D.A. and J.T. Saari. Dietary copper deficiency impairs nitric oxide-mediated signal transduction. Research Signpost, Recent Research Developments in Nutrition 3: 65-70, 2000.
3. Lominadze, D., I.G. Joshua and D.A. Schuschke. Blood flow shear rates in arterioles of spontaneously hypertensive rats at early and established stages of hypertension. Clin. Exp. Hypertension 23: 317-328, 2001.
4. Lentsch, A. B., A. Kato, J.T. Saari and D.A. Schuschke. Augmented metalloproteinase activity and acute lung injury in copper deficient rats. Am. J. Physiol. 281: L387-L393, 2001.
5. Schuschke, D.A., J.T. Saari and F.N. Miller. Leukocyte-endothelial adhesion is impaired in the cremaster muscle microcirculation of the copper-deficient rat. Immunol. Lett. 76: 139-144, 2001.
6. Lominadze, D. J.T. Saari, S.S. Percival and D.A. Schuschke. Proinflammatory effects of copper deficiency on neutrophils and lung endothelial cells. Immunol. Cell Biol. 82:231-238, 2004.
7. Falcone, J.C., J.T. Saari, Y.J. Kang and D.A. Schuschke. Vasoreactivity in an adult rat model of marginal copper deficiency. Nutr. Res. 25:177-186, 2005.
8. Li, Y., L. Wang, D.A. Schuschke, Z. Zhou, J.T. Saari and Y.J. Kang. Cardiomyopathy induced by marginal dietary copper restriction in rats. J. Nutr. 135:2130-2136, 2005.
9. Gordon, S.A., D. Lominadze, J.T. Saari, A.B. Lentsch and D.A. Schuschke. Impaired deformability of copper-deficient neutrophils. Exp. Biol. Med. 230:543-548, 2005.
10. Kalea, A.Z., F.N. Lamari, A.D. Theocharis, P. Cordopatis, D.A. Schuschke, N.K. Karamanos and D.J. Klimis-Zacas. Wild blueberry (Vaccinium angustifolium) consumption affects the composition and structure of glycosaminoglycans in Sprague-Dawley rat aorta. J. Nutr. Biochem. 17:109-116, 2006.