Contact Information
231 E. Chestnut, N-97
Louisville, Ky 40202
Beverly Thompson (502) 629-5820
Fax: (502) 629-5285
24/7 pager: (502) 620-0000
Email: KCPCRU@louisville.edu 

Faculty
Janice E. Sullivan, M.D., medical director, research biography
Carmen Tania Condurache, M.D.  
 

The Kosair Charities Pediatric Clinical Research Unit (KCPCRU) is the region’s first state-of-the-art clinical facility dedicated solely to conducting inpatient and outpatient pediatric clinical pharmacology studies. The primary mission of the KCPCRU, which opened in May 2002, is three-fold: research (clinical and translational), clinical service, and education/training.

The clinical facilities of the KCPCRU are located on the second floor of Kosair Children’s Hospital. There are three private inpatient rooms dedicated solely for infants, children and adolescents participating in clinical pharmacology research studies. The fully-equipped nursing unit has facilities for phlebotomy and urine collection. The unit also contains a specimen processing laboratory, satellite research pharmacy, patient kitchen and playroom equipped with age-appropriate toys, books and games.

The KCPCRU also has several core laboratories that support the translational science mission of the center. These include the Bioanalytical and Pharmacogenetics Core Facilities within the Department of Pharmacology and Toxicology and the Proteomics Core Laboratory within the Department of Medicine.

In addition, the KCPCRU, in collaboration with investigators in the Proteomics Core Laboratory, recently secured approximately $3 million in federal earmarks from the Department of Energy to establish the U of L Pediatric Clinical Proteomic Center. This funding is being used to establish the physical infrastructure to support our pharmacoproteomics research.

The KCPCRU is also one of 13 sites in the Pediatric Pharmacology Research Unit (PPRU) network, a cooperative network of clinical pediatric pharmacology research sites in the United States funded by the National Institute of Child Health and Human Development (NICHD).

Approximately 100 – 150 subjects are enrolled into KCPCRU clinical/translational research trials annually. These studies include medication for:

• Pain control
• Sedation
• Immunosuppression
• Infections
• Hypertension
• Septic shock
• Asthma
• Platelet inhibition
• Heparin induced thrombocytopenia
• Restless legs syndrome
• Gastric esophageal reflux (GERD)
  

In addition, children are being enrolled in genotyping and phenotyping studies to evaluate the effect of genetics on drug metabolizing enzymes and key pathogenic mediators of disease.

These studies are conducted by a multi-disciplinary team within the U of L Department of Pediatrics and represent the collaboration and commitment to Pediatric Clinical Pharmacology research among basic and applied scientists within and external to the Department of Pediatrics.

For questions about research regulatory documents, call Lisa Good, BA, CCRC (502) 629-5874.

For questions about research contract issues, call Christie Van Buren, Unit Business Manager (502) 629-5016.

To refer patients or discuss study subject related issues, call (502) 629-5820 and request to talk with a Research Nurse.

Click here for University of Louisville Proteomics Laboratory. http://kdp.louisville.edu/proteomelab/