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C William Helm, MD

Associate Professor, Division of Gynecologic Oncology

Photo of C. Helm, MD

Education:

MB BChir*, The Middlesex Hospital Medical School, London, England
* British degree equivalent to US MD.

Residencies:

  • Senior House Officer, Surgery, Norfolk and Norwich Hospital, Norfolk, United Kingdom, 1978 – 1981
  • Registrar in Surgery, St. Thomas’ Hospital, London, United Kingdom, 1981 – 1983
  • Senior House Officer, Obstetrics, Queen Charlotte’s Maternity Hospital, London, United Kingdom, 1983 – 1984
  • Senior House Officer, Gynecology, The Chelsea Hospital for Women, Chelsea, London, United Kingdom, 1984 – 1985
  • Registrar, Obstetrics and Gynecology, The Middlesex and University College Hospitals, London, United Kingdom, 1985 – 1987
  • Senior Registrar, Gynecologic Oncology Unit, Edinburgh Royal Infirmary, Edinburgh, Scotland, 1987 – 1989

Clinical Interests:

Gynecologic cancers

Research Interests:

  • Gynecologic cancers and treatments including chemotherapy and surgery
  • Principal Investigator: University of Louisville Ovarian Screening Study
  • Principal Investigator: HYPERO Registry for patients with ovarian cancer treated with hyperthermic intraperitoneal chemotherapy
  • Research focus is on improving the detection and treatment of ovarian, endometrial and cervical cancer
  • Past Co-Chair World Ovarian Cancer Working Group for International Society for Peritoneal Surface Malignancy

Professional Memberships and Activities:

  • 2009 – Present American Society of Peritoneal Surface Malignancies
  • 2008 – Present American Society of Gynecologic Laparoscopists
  • 2000 – Present Louisville Obstetrical and Gynecological Society
  • 1996 – Present American Society of Clinical Oncology
  • 1996 – Present European Society of Gynaecologic Oncology
  • 1995 – Present American College of Obstetricians & Gynecologists
  • 1993 – Present International Gynecologic Cancer Society

Course and Symposium Director:

  • Initiator and Director, Advanced Upper Abdominal and Bowel Surgery Inaugural Course, James Graham Brown Cancer Center, University of Louisville, Louisville, Kentucky, May 2008 and May 2009, and annually thereafter.
  • Chair: Advanced Laparoscopy for Gynecologic Oncologist, American Society of Gynecologic Laparoscopists, Las Vegas, October 29th 2008
  • Director: International Symposium on Peritoneal Therapy for Ovarian Cancer, University of Louisville, May 2005

Journal Editorial Boards and Peer Reviewer of Manuscripts

  • Reviewer for Annals of Surgical Oncology - 2008
  • Reviewer for Journal of Surgical Oncology - 2008
  • Editorial Board: Journal of Ovarian Research - 2008

Recent Publications:

  • Pappas J, Jung W-J, Barda AK, Lin WL, Fincke JE, Purev E, Radu M, Gaughan, J, Helm CW, Hernandez E, Freedman RS, Platsoucas CD. Substantial proportions of identical beta-chain T-cell receptor transcripts are present in epithelial ovarian carcinoma tumors. Cellular Immunology. 234(2):81-101, 2005
  • Moore GD, Lear SC, Wills-Frank LA, Martin AW, Snyder JW, Helm CW. Differential expression of CDK inhibitors p16, p21cip1, p27kip1, and cyclin E in cervical cytological smears prepared by the ThinPrep method. Diagnostic Cytopathology 32(2):82-87, 2005.
  • Shondel SM, Helm CW , Gercel-Taylor C, Taylor DD. Differential expression of T-cell CD3-zeta chains in patients with cervical dysplasia before and after treatment. International Journal of Gynecologic Cancer. 17(6):1278-1282, 2007.
  • Helm CW, Toler CR, Martin III RS, Gordinier ME, Parker LP, Metzinger DS, Edwards RP. Cytoreduction and Intraperitoneal Heated Chemotherapy (IPHC) for the Treatment of Endometrial Carcinoma Recurrent Within the Peritoneal Cavity. International Journal of Gynecologic Cancer 17(1);204-9, 2007
  • Helm CW, Randall-Whitis L, Martin R, Metzinger DS, Gordinier ME, Parker LP, Edwards RP. Hyperthermic Intraperitoneal Chemotherapy in Conjunction with Surgery for the Treatment of Recurrent Ovarian Carcinoma. Peer Reviewed Gynecologic Oncology 105(1):90-6, 2007
  • Pendergrass M, Gordinier ME, Parker LP, Metzinger DS, Helm CW. Retraction of an intraperitoneal chemotherapy port: A case report and literature review. Int J Gynecol Cancer 17(5):1131-1133, 2007.
  • Helm CW, Lorenz D, Rising WR, Meyer D, Wulff J. Cochrane Database Syst Rev. 2007 Oct 17;(4):CD003296.
  • Helm CW, Bristow RE, Kusamura S, Baratti D, Deraco M. Hyperthermic intraperitoneal chemotherapy with and without cytoreductive surgery for epithelial ovarian cancer. Journal of Surgical Oncology. 2008 Sep 15;98(4):283-90.
  • Reuter NP, MacGregor JM, Woodall CE, Sticca RP, Helm CW, Scoggins CR, McMasters KM, Martin RCG. Preoperative performance status predicts outcome following heated intraperitoneal chemotherapy. The American Journal of Surgery (2008) 196, 909–914.
  • Garbett NC, Mekmaysy CS, Helm CW, Jenson AB, Chaires JB. Differential Scanning Calorimetry of Blood Plasma for Clinical Diagnosis and Monitoring. Experimental and Molecular Pathology 86 (2009) 186-191.
  • Helm CW, States JC. Enhancing the efficacy of cisplatin in ovarian cancer treatment – could arsenic have a role. Journal of Ovarian Research. 2009, 2:2
    Helm, CW. The role of hyperthermic IP chemotherapy in Ovarian Cancer. Invited Review. The Oncologist. Accepted for publication May 2009.

Leadership:

  • 2009 – Present Board of Directors, University of Louisville Athletic Association
  • 2001 – Present Clinical Scientific Review Committee, James Graham Brown Cancer Center, Louisville, Kentucky
  • 2003 – Present Surgery Surgical Advisory Committee, Jewish Hospital, Louisville, Kentucky
  • 2001 – Present Medical Advisory Board, Ovarian Awareness of Kentucky (O.A.K.)
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