Irene Litvan, MD
Raymond Lee Lebby Professor of Parkinson Disease Research
Director, Division of Movement Disorders
University of Louisville
Louisville, KY 40292
Clinical Phone: (502) 582-7654
Academic Phone: (502) 852-3655
Education
1979 M.D.:
Universidad de la Republica
Facultad de Medicina,
Avda Gral Flores s/n
Montevideo, Uruguay
Training
1979-1980 Intern in Medicine
Departmento de Medicina Interna, (Dr. L. Drobnic)
Hospital General Nuestra Señora del Mar,
Paseo Maritimo 25-29,
08003 Barcelona, Spain
1980 Resident in Family Practice
Hospital General Nuestra Señora del Mar,
Departamento de Medicina Interna,
Paseo Maritimo 25-29,
08003 Barcelona, Spain
1980-1985 Resident in Neurology
Department of Neurology, (Dr. J.Ma. Grau i Veciana)
Hospital de la Santa Creu i Sant Pau,
Avda Sta Maria Claret i St Pau 167
08025 Barcelona, Spain
1984-1985 Chief Resident,
Department of Neurology,
Hospital de la Santa Creu i Sant Pau,
Avda Sant Antoni Ma Claret 167,
Barcelona 08025, Spain
1985-1986 Research Fellow
Department of Neurology, (Dr. E. Tolosa)
Hospital Clinic i Provincial de Barcelona,
Villarroel 170, Barcelona 08036, Spain
1985-1986 Fellow in Neuropsychology
Department of Neurology, (Dr. C. Junque),
Hospital de la Santa Creu i Sant Pau,
Avda Sant Antoni Maria Claret 167,
Barcelona 08025, Spain
1986-1988 Research Fellow in Dementia & Movement Disorders
Experimental Therapeutics Branch, (Dr. T.N. Chase)
Bdg. 10, Rm 5C 103,
National Institutes of Neurological Disorders and Stroke,
National Institutes Health,
Bethesda, MD 20892
1988-1989 Resident PGY-1 in Psychiatry
St. Elizabeth Hospital (Dr. J. Livingood)
Washington, D.C. 20032
1989-1992 Resident in Neurology
Department of Neurology (Dr. J. Pincus)
Georgetown University Hospital
3800 Reservoir Road NW
Washington, DC 20007
1991-1992 Chief Resident,
Georgetown University Hospital &
VAMC Washington DC
Department of Neurology
1992-1997 Senior Staff Fellow
Neuroepidemiology Branch (Dr. Karin B. Nelson)
NINDS, NIH
Federal Bdg, Rm. 714
Bethesda, MD 20892-9130
Board Certifications
1994 US Board Certified in Neurology and Psychiatry January/94
Biography
Dr. Litvan receeved her Medical Degree from the University of Uruguay and later completed her Neurology Residency and fellowship in Neuropsychology and Dementia, at the Hospital Santa Creu i Sant Pau, in Barcelona, Spain.
In 1986, Dr. Litvan joined the Experimental Therapeutics Branch, National Institutes of Health (NIH), as a Post-doctoral fellow. After completing a required 2nd Residency in Neurology at Georgetown UniversiNeurology University, Dr. Litvan was appointed as a Senior Staff Fellow in the Neuroepidemiology Branch of the National Institute of Neurologic Disorders and Stroke. She left there in 1997 to join the Henry M. Jackson Foundation, where she remained as a guest scientist until 2002.
In 2000, Dr. Litvan opened her own clinical practice in Bethesda, MD. In 2002, Dr. Litvan became the Raymond Lee Lebby endowed Professor of Parkinson Disease Research at the University of Louisville and the Director of its Division of Movement Disorders.
In 2006, she became the Director of the Division of Movement Disorders at the Frazier Rehabilitation Institute, as well.
Dr. Litvan is an American Board-Certified Neurologist. She has published numerous peer-reviewed articles on the diagnosis of neurodegenerative, parkinsonian, and dementia disorders, as well as on the neuropsychiatry of cortical and subcortical dementias. She was senior editor of the first book on progressive supranuclear palsy (PSP) (Oxford University Press, 1992).
Clinical Interests
Research Interests
Recent Publications
Gröschel K, Kastrup A, Litvan I, Schulz JB. Penguins and hummingbirds: midbrain atrophy in progressive supranuclear palsy. Neurology, 2006;66(6):949-50
Sun M, Latourelle JC; Wooten GF; Lew,MF; Klein C; Shill HA; Golbe LI; Mark MH; Racette BA; Perlmutter JS; Parsian A; Guttman M; Nicholson G; Xu G; Wilk JB, Saint-Hilaire MH; DeStefano AL; Prakash R; Williamson S; Suchowersky O; Labelle N; Growdon JH; Singer C; Watts RL; Goldwurm S; Pezzoli G; Baker KB; Giroux ML; Pramstaller PP; Burn DJ; Chinnery PF; Sherman S; Vieregge P; Litvan I; Al-Yamani E; Gillis T; MacDonald ME; Myers RH; Gusella JF. Heterozygosity for Parkin Mutation Influences Onset Age in Familial Parkinson’s Disease: The GenePD Study. Archives of Neurology, 2006;63(6):826-32.
Schragg A, Selai C, Quinn N, Lees A, Litvan I, Lang A, Poon Y, Bower J, Burn D, Hobart J. Measuring the Quality of Life in PSP. The PSP-QofL. Neurology, 2006;67(1):39-44.
Wilk JB., Tobin JE., Suchowersky O, Shill HA, Klein C, Wooten FG, Lew MF, Mark MH, Guttman M, Watts RL, Singer C, Growdon JH, Latourelle JC, Saint-Hilaire MH, DeStefano AL, Prakash R, Williamson S, Berg CJ, Sun M, Goldwurm S, Pezzoli G, Racette BA, Perlmutter JS, Parsian A, Baker KB, Giroux ML, Litvan I, Pramstaller PP, Nicholson G, Burn DJ, Chinnery PF, Vieregge P, Slevin JT, Cambi F, MacDonald ME, Gusella JF, Myers RH, Golbe LI. Herbicide exposure modifies GSTP1 haplotype association to Parkinson onset age: The GenePD Study. Neurology, 2006;67(12):2206-10.
Melquist S, Craig DW, Huentelman MJ, Crook R, Pearson JV, Baker M, Zismann VL, Gass J, Adamson J, Szelinger S, Corneveaux J, Cannon A, Coon KD, Lincoln S, Adler C, Tuite P, Calne DB, Bigio EH, Uitti RJ, Wszolek ZK, Golbe LI, Caselli RJ, Graff-Radford N, Litvan I, Farrer M, Dickson DW, Hutton M, Stephan D. Identification of a novel risk locus for Progressive Supranuclear Palsy by a pooled genome-wide scan of 500,288 SNPs. American Journal of Human Genetics, 2007; 80(4):769-778.
Litvan I, Halliday G, Hallett M, Goetz CG, Rocca W, Duyckaerts C, Ben-Shlomo Y, Dickson DW, Lang AE, Chesselet MF, Langston WJ, Di Monte DA , Gasser T, Hagg T, Hardy J, Jenner P, Melamed E, Myers RH, Parker DJr., Price DL. Critical Issues on the Etiopathogenesis of Parkinson Disease and Suggestions for Future Research (Part I). Journal of Neuropathology and Experimental Neurology 2007; 66(4): 251-7.
Litvan I, Chesselet MF, Gasser T, Di Monte DA, Parker D Jr., Hagg T, Hardy J, Jenner P, Myers RH, Price DL, Hallett M, Langston WJ, Lang AE, Halliday G, Rocca W, Duyckaerts C, Dickson DW, Ben-Shlomo Y, Goetz CG, Melamed E, Critical Issues on the Etiopathogenesis of Parkinson Disease and Suggestions for Future Research (Part II). Journal of Neuropathology and Experimental Neurology, 2007 66 (5):329-336.
Emre M, Aarsland D, Brown R, Burn DJ, Duyckaerts C, Mizuno Y, Broe GA, Cummings J, Dickson DW, Gauthier S, Goldman J, Goetz C, Korczyn A, Lees A, Levy R, Litvan I, McKeith I, Olanow W, Poewe W, Quinn N, Sampaio C, Tolosa E, Dubois B. Clinical diagnostic criteria for dementia associated with Parkinson disease. Movement Disorders, 2007, Sep 15;22(12):1689-707.
Dubois B, Burn D, Goetz C, Aarsland D, Brown RG, Broe GA, Dickson D, Duyckaerts C, Cummings J, Gauthier S, Korczyn A, Lees A, Levy R, Litvan I, Mizuno Y, McKeith IG, Olanow CW, Poewe W, Sampaio C, Tolosa E, Emre M. Diagnostic procedures for Parkinson's disease dementia: Recommendations from the movement disorder society task force. Movement Disorders, 2007, Dec 15;22(16):2314-24.
Chand P, Litvan I. Progressive Supranuclear Palsy and Corticobasal Degeneration: Similarities and Differences. Future Neurology. In press.
