Radhika Vaishnav, PhD
Assistant Professor of Neurology
Associate Faculty, Department of Physiology
Associate Member, Kentucky Spinal Cord Injury Research Center
Medical Dental Research Building # 526
University of Louisville School of Medicine
Louisville, KY 40292
Phone: (502) 852-2230
Maharaja Sayajirao University,
Degree: M.Sc., Biochemistry
Loyola University of Chicago Stritch School of Medicine, Maywood, Illinois. Degree: M.S., Molecular Biology
University of Kentucky College of Medicine, Lexington, Kentucky. Degree: Ph.D., Physiology
Spinal Cord and Brain Injury Research Center,
University of Kentucky College of Medicine
Dr. Vaishnav received her Bachelors in Zoology in 1996 and Masters in Biochemistry in 1998 from the Maharaja Sayajirao University in Vadodara, India. She received further training in Molecular Biology at Loyola, completing a Masters' thesis under the guidance of Dr. Lucio Miele in 2002. She worked at the Oregon Health Sciences University prior to pursuing doctoral studies at the University of Kentucky. During her dissertation studies under the mentorship of Dr. Thomas Getchell, she combined contemporary proteomics and genomics with cellular and 'tissue-level analyses to obtain a comprehensive "systems level" understanding of olfactory degeneration. She then received an NIH National Research Service Award to pursue her postdoctoral training in therapeutic mechanisms of acute spinal cord injury in Dr. Edward Hall's lab. She joined the faculty at the University of Louisville School of Medicine in 2010.
In addition to her interest in research, Dr. Vaishnav enjoys teaching. She has mentored undergraduate and graduate students and taught various courses at the University of Kentucky, University of Louisville and the Kentucky Community and Technical College System.
Neurodegeneration has been associated with certain molecular and cellular processes that include elevated oxidative stress and associated DNA damage, protein oxidation, and lipid peroxidation; mitochondrial metabolic decline; increased apoptosis; and increased inflammation. Research has revealed that while neuronal loss by apoptosis seems to playa major role in neurodegenerative disorders, it is unlikely to be a predominant factor in normally aging brain. Rather, subtle molecular changes, such as oxidative stress-induced damage and mitochondrial impairments, appear to have a significant impact on neuronal functional decline in aging brain, predisposing aging brain to further insults and leading to the dysfunction and apoptosis that is characteristic of neurodegenerative disorders. Dr. Vaishnav's overall interests are in identifying basic molecular alterations associated with normal aging and neurodegenerative conditions in order to gain mechanistic insights and identify therapeutic targets.
- R.A. Vaishnav, I.N. Singh, D.M. Miller, E.D. Hall "Differential Effects of Lipid Peroxidation Products on Brain and Spinal Cord Mitochondria: An In-Vitro Assessment of Mitochondrial Dysfunction." 1 Neurotrauma, 2010 Jul;27(7):1311-20.
- E.D. Hall, R.A. Vaishnav, A.G. Mustafa "Antioxidant therapies for Traumatic Brain Injury" Neurotherapeutics, 2010 Jan;7(1):51-61.
- K.M. Carrico, R.A. Vaishnav, E.D. Hall "Temporal and spatial dynamics of peroxynitrite-induced oxidative damage after spinal cord contusion injury." J. Neurotrauma, 2009 Aug;26(8):1369-78.
- R.A. Vaishnav, M.L. Getchell, L. Huang, M. Hersh, A.J. Stromberg, T.V. Getchell "Cellular and molecular characterization of oxidative stress in the olfactory epithelium ofthe Harlequin mutant mouse." J. Neurosci. Res., 2008; 86(1):165-182.
- R.A. Vaishnav, M.L. Getchell, H.F. Poon, K.R. Barnett, W.M. Pierce, lB. Klein, SA Hunter, D.A. Butterfield, T.V. Getchell "Oxidative stress in the aging murine olfactory bulb: redox proteomics and cellular localization." J. l\Jeurosci. Res., 2007; 85(2):373-85.
- M.L. Getchell, H. Liu, R.A. Vaishnav, A.S. Borders, 1 Witta, N. Subhedar, W. de Villiers, A.l Stromberg, T.V. Getchell "Temporal gene expression profiles oftarget-ablated olfactory epithelium in mice with disrupted expression of scavenger receptor A: impact on macrophages." Physiol. Genomics, 2006; 27(3):245-63.
- H.F.Poon, R.A. Vaishnav, T.V. Getchell, M.L. Getchell, DA Butterfield "Quantitative proteomics analysis of specific protein expression and oxidative modification in aged mice brain -insights into compensatory mechanisms for lost protein activity due to age-related oxidative modification." Neurobiol. Aging, 2006; 27(7):1010-9.
- H.F. Poon (co-first author), R.A. Vaishnav (co-first author), D.A. Butterfield, M.L. Getchell, T.V. Getchell "Proteomic identification of differentially expressed proteins in the aging murine olfactory system and transcriptional analysis of the associated genes." J. Neurochem., 2005; 94, 380-392.
- T.V. Getchell, H. Liu, R.A. Vaishnav, K. Kwong, A.J. Stromberg, and M.L. Getchell "Temporal profiling of gene expression during neurogenesis and remodeling in the olfactory epithelium at short intervals after target ablation." J. Neurosci. Res., 2005; 80(3):309-29.
- K. Kwong, R.A. Vaishnav, Y. Liu, N. Subhedar, A.J. Stromberg, M.L. Getchell, and T.V. Getchell "Target ablation-induced regulation of macrophage recruitment into the olfactory epithelium of Mip-1alpha-/mice and restoration of function by exogenous MIP-1alpha." Physiol. Genomics., 2004; 20(1):73-86.
- S. Weijzen, P. Rizzo, M. Braid, R. Vaishnav, S.M. Jonkheer, A. Zlobin, BA Osborne, S. Gottipati, J.e. Aster, W.e. Hahn, M. Rudolf, K. Siziopikou, W.M. Kast, L. Miele "Activation of Notch-1 signaling maintains the neoplastic phenotype in Ras-transformed cells." Nature Medicine, 2002; 8(9):979-86