Dr. Ward's Research
Our clinical and laboratory research is aimed at increasing understanding of uremia and the hemodialysis procedure with the objective of improving long-term outcomes for hemodialysis patients. Clinical research projects include studies of factors affecting the removal of small proteins thought to be important uremic toxins, including membrane and dialyzer properties; solute transfer between body compartments; and, the role of convective solute removal. Although β2-microglobulin is frequently used as a representative of small protein uremic toxins, we also have the capability of examining larger proteins, including complement factor D and immunoglobulin light chains, in these studies.
Laboratory research projects are centered on the role of neutrophils in the oxidant stress associated with chronic kidney disease and hemodialysis. This work is related to basic laboratory research in neutrophil biology being performed in collaboration with Drs. Ken McLeish and Silvia Uriarte. We are interested in determining how neutrophils are activated in hemodialysis patients and at defining strategies to reduce that activation and its associated oxidant stress.
Karen Brinkley, M.S.