Jon B. Klein, M.D., Ph.D. Professor of Medicine James Graham Brown Foundation Chair in Proteomics University of Louisville Health Care Outpatient Center 401 East Chestnut Street, Ste. 690 Louisville, KY 40202 502-852-5757 - Academic Office 502-813-6699 - Patient Appointments

Clinical Expertise

Nephrology

Board Certifications

• American Board of Internal Medicine - Internal Medicine / Nephrology

Education and Training

• Medical School: University of Texas

• Residency: University of Kansas Medical Center

• Fellowship: University of Louisville

• Ph.D.: University of Louisville

Clinical Expertise

• Merchant ML, Gaweda AE, Dailey AJ, Wilkey DW, Zhang X, Rovin BH, Klein JB, Brier ME. Oncostatin M receptor β and cysteine/histidine-rich 1 are biomarkers of the response to erythropoietin in hemodialysis patients. Kidney Int. 2011 Mar;79(5):546-54. Epub 2010 Dec 8.

• Catapano G, Klein JB. Ich denk' es war ein gutes Jahr* (Reinhard Mey, 1968) - The year 2010 balance. Int J Artif Organs. 2010 Dec;33(12):841-3.

• Merchant ML, Klein JB. Proteomic discovery of diabetic nephropathy biomarkers. Adv Chronic Kidney Dis. 2010 Nov;17(6):480-6. Review.

• Arthur JM, Klein JB. Proteomics in CKD. Adv Chronic Kidney Dis. 2010 Nov;17(6):453-4.

• Rood IM, Deegens JK, Merchant ML, Tamboer WP, Wilkey DW, Wetzels JF, Klein JB. Comparison of three methods for isolation of urinary microvesicles to identify biomarkers of nephrotic syndrome. Kidney Int. 2010 Oct;78(8):810-6. Epub 2010 Aug 4.

• Mischak H, Allmaier G, Apweiler R, Attwood T, Baumann M, Benigni A, Bennett SE, Bischoff R, Bongcam-Rudloff E, Capasso G, Coon JJ, D'Haese P, Dominiczak AF, Dakna M, Dihazi H, Ehrich JH, Fernandez-Llama P, Fliser D, Frokiaer J, Garin J, Girolami M, Hancock WS, Haubitz M, Hochstrasser D, Holman RR, Ioannidis JP, Jankowski J, Julian BA, Klein JB, Kolch W, Luider T, Massy Z, Mattes WB, Molina F, Monsarrat B, Novak J, Peter K, Rossing P, Sánchez-Carbayo M, Schanstra JP, Semmes OJ, Spasovski G, Theodorescu D, Thongboonkerd V, Vanholder R, Veenstra TD, Weissinger E, Yamamoto T, Vlahou A. Recommendations for biomarker identification and qualification in clinical proteomics. Sci Transl Med. 2010 Aug 25;2(46):46ps42.

• Cummins TD, Barati MT, Coventry SC, Salyer SA, Klein JB, Powell DW. Quantitative mass spectrometry of diabetic kidney tubules identifies GRAP as a novel regulator of TGF-beta signaling. Biochim Biophys Acta. 2010 Apr;1804(4):653-61. Epub 2009 Oct 22.

• Rane MJ, Song Y, Jin S, Barati MT, Wu R, Kausar H, Tan Y, Wang Y, Zhou G, Klein JB, Li X, Cai L. Interplay between Akt and p38 MAPK pathways in the regulation of renal tubular cell apoptosis associated with diabetic nephropathy. Am J Physiol Renal Physiol. 2010 Jan;298(1):F49-61. Epub 2009 Sep 2.

• Merchant ML, Powell DW, Wilkey DW, Cummins TD, Deegens JK, Rood IM, McAfee KJ, Fleischer C, Klein E, Klein JB. Microfiltration isolation of human urinary exosomes for characterization by MS. Proteomics Clin Appl. 2010 Jan;4(1):84-96. doi: 10.1002/prca.200800093. Epub 2009 Nov 11.