Dr. Klein's Research
by
Kathleen H. Sauer
—
last modified
Feb 28, 2008 11:39 AM
- PI: Jon B. Klein, M.D., Ph.D.
Department of Veterans Affairs: Basic Science Merit Review
“Control of Immune Cells: Role of a NovelChemotatic Receptor
This project uses proteomic analysis to identify proteins regulated in neutrophils rescued from apoptosis by inflammatory products. - PI: Dr. Paul N. Epstein Collaborator: Jon B. Klein, M.D., Ph.D
R01 HL62892-01 - National Institutes of Health
“Antioxidant transgene in diabetic cardiomyopathy”
Proteomic analysis will be performed of cardiac mitochondria in diabetic animals with ans without cardiac-specific conditional antioxidant transgenes. - PI: Dr. Paul N. Epstein Collaborator: Jon B. Klein, M.D., Ph.D
R01 HL62892-01 - National Institutes of Health
“Antioxidant transgene in diabetic cardiomyopathy”
Proteomic analysis will be performed of cardiac mitochondria in diabetic animals with ans without cardiac-specific conditional antioxidant transgenes. - PI: Kenneth R. McLeish, M.D. Co-PI: Jon B. Klein, M.D., Ph.D.
Department of Veterans Affairs: Basic Science Merit Review
“Mechanisms of Neutrophil Activation”
The goal of this project is to identify substrates of p38 MAPK on individual neutrophil granule subtypes using functional proteomic methodologies. - PI: Kenneth R. McLeish, M.D. Co-PI: Jon B. Klein, M.D., Ph.D.
Department of Veterans Affairs: Basic Science Merit Review
“Mechanisms of Neutrophil Activation”
The goal of this project is to identify substrates of p38 MAPK on individual neutrophil granule subtypes using functional proteomic methodologies. - PI: Kenneth R. McLeish, M.D. Co-PI: Jon B. Klein, M.D., Ph.D.
Department of Veterans Affairs: Merit Review
Title: “Surrogate Markers of Early Acute Renal Injury” The aims of this project are to utilize mass spectrometric methods to identify sensitive and specific markers of acute renal injury in a hospital setting. Dr. Merchant is responsible for overseeing 2DE and LC MALDI MS methods. - PI: Kenneth R. McLeish, M.D. Co-PI: Jon B. Klein, M.D., Ph.D.
Department of Veterans Affairs: Merit Review
Title: “Surrogate Markers of Early Acute Renal Injury” The aims of this project are to utilize mass spectrometric methods to identify sensitive and specific markers of acute renal injury in a hospital setting. Dr. Merchant is responsible for overseeing 2DE and LC MALDI MS methods. - PI: Jon B. Klein, M.D., Ph.D.
R01 DK067638 02 - Joslin Diabetes Center (NIH-Sub Contract)
“The Urinary Proteome and Renal Function Loss in Diabetes”
Proteomic analysis of urine from clinical diabetic samples will be analyzed in order to identify proteins associated with diabetic nephropathy. - PI: Jon B. Klein, M.D., Ph.D.
R01 DK067638 02 - Joslin Diabetes Center (NIH-Sub Contract)
“The Urinary Proteome and Renal Function Loss in Diabetes”
Proteomic analysis of urine from clinical diabetic samples will be analyzed in order to identify proteins associated with diabetic nephropathy. - PI: Donald M. Miller Co-PI Jon B. Klein, M.D., Ph.D
(COBRE-RR-02-007) - National Institutes of Health/NCRR
“Center of Biomedical Research Excellence in Molecular Targets”
This project is to establish a Core Proteomics Laboratory for the Brown Cancer Center COBRE. - PI: Janice Sullivan Co-PI Jon B. Klein, M.D.,Ph.D.5
U10HD045934-03 - National Institutes of Health
“Center for Pediatric Clinical Pharmacology Research”
This project requires the creation of a core proteomic laboratory and correlation of proteomic data in patients with clinical pharmacogenomic studies. - PI: Jon B. Klein, M.D., Ph.D
DE-FG02-05ER6406
Office of Science Financial Assistance Program-U.S. DOE
“Pediatric Clinical Proteomics Center” - PI: Tezel Tongalp M.D. Primary Mentor: Jon B. Klein, M.D., Ph.D
K08 EY016120 - NIH – Mentored Clinical Scientist Development Award
“Proteomic Analysis of Age-Related Macular Degeneration”
