Guidot delivers annual Derby Lecture
Picking a winner for the Kentucky Derby is never a sure bet. Selecting a speaker for University of Louisville Department of Medicine's annual Derby Lecture was a much safer pick.
Dr. David Guidot of Emory University delivered the annual lecture Thursday morning, speaking on the topic of "Alcohol and the Lung: A Physician’s Perspective."
After stints at the University of Michigan, University of Minnesota-Twin Cities and the University of Colorado, Dr. Guidot now serves as the Jeffrey Pine Professor of Medicine at Emory University in Atlanta, Ga.
In addition to that duty at Emory, he is also the Division Director of Pulmonary, Allergy and Critical Care Medicine as well as the Director of the Alcohol and Lung Biology Center.
Dr. Guidot's primary areas of research include the mechanisms by which chronic alcohol abuse renders the lung susceptible to acute injury, particularly in response to sepsis or other acute inflammatory insults.
Specific facets including the role of angiotensin II in mediating ethanol-induced oxidative stress and alveolar epithelial cell dysfunction, and the potential efficacy of granulocyte/macrophage colony-stimulating factor (GM-CSF) treatment for patients with alcohol abuse at high risk for acute lung injury.
The primary model used in his laboratory is the Lieber-DeCarli diet in Sprague-Dawley rats. However, newer projects are using ethanol-fed mice (with ethanol added to the drinking water) to take advantage of relevant transgenic constructs (such as GM-CSF under-expressing and over-expressing mice, as well as mice that express HIV-related proteins.
► Click here for a more detailed biography of Dr. David Guidot