Kenneth R. McLeish, M.D.

Kenneth R. McLeish, M.D. Professor of Medicine University of Louisville Health Care Outpatient Center 401 East Chestnut Street, Ste. 690 Louisville, KY 40202 502-852-5757 - Academic Office 502-813-6699 - Patient Appointments

Clinical Expertise

Nephrology; Lupus Nephritis; Glomerulonephritis

Board Certificaions

• American Board of Internal Medicine - Internal Medicine / Nephrology

Education and Training

• Medical School: Indiana University

• Residency: Indiana University Medical Center

• Fellowship: Indiana University Medical Center

Recent Publications

• McLeish KR, Merchant ML, Klein JB, Ward RA. Technical note: proteomic approaches to fundamental questions about neutrophil biology. J Leukoc Biol. 2013 Mar 7. [Epub ahead of print] PubMed PMID: 23470899.

• Schissler MM, Zaidi S, Kumar H, Deo D, Brier ME, McLeish KR. Characteristics and outcomes in community-acquired versus hospital-acquired acute kidney injury. Nephrology (Carlton). 2013 Mar;18(3):183-7. doi: 10.1111/nep.12036. PubMed PMID: 23336108.

• Uriarte SM, Rane MJ, Merchant ML, Jin S, Lentsch AB, Ward RA, McLeish KR. Inhibition of neutrophil exocytosis ameliorates acute lung injury in rats. Shock. 2013 Mar;39(3):286-92. doi: 10.1097/SHK.0b013e318282c9a1. PubMed PMID: 23364427; PubMed Central PMCID: PMC3578018.

• McLeish KR, Uriarte SM, Tandon S, Creed TM, Le J, Ward RA. Exocytosis of Neutrophil Granule Subsets and Activation of Prolyl Isomerase 1 Are Required for Respiratory Burst Priming. J Innate Immun. 2013 Jan 26. [Epub ahead of print] PubMed PMID: 23363774.

• Timár CI, Lorincz AM, Csépányi-Kömi R, Vályi-Nagy A, Nagy G, Buzás EI, Iványi Z, Kittel A, Powell DW, McLeish KR, Ligeti E. Antibacterial effect of microvesicles released from human neutrophilic granulocytes. Blood. 2013 Jan 17;121(3):510-8. doi: 10.1182/blood-2012-05-431114. Epub 2012 Nov 8. PubMed PMID: 23144171; PubMed Central PMCID: PMC3548170.

• Liu W, Yan M, Liu Y, McLeish KR, Coleman WG Jr, Rodgers GP. Olfactomedin 4 inhibits cathepsin C-mediated protease activities, thereby modulating neutrophil killing of Staphylococcus aureus and Escherichia coli in mice. J Immunol. 2012 Sep 1;189(5):2460-7. doi: 10.4049/jimmunol.1103179. Epub 2012 Jul 27. PubMed PMID: 22844115; PubMed Central PMCID: PMC3424379.

• Gomez-Cambronero J, Allen LA, Cathcart MK, Justement LB, Kovacs EJ, McLeish KR, Nauseef WM. Writing a first grant proposal. Nat Immunol. 2012 Jan 19;13(2):105-8. doi: 10.1038/ni.2183. PubMed PMID: 22261956.

• Uriarte SM, Rane MJ, Luerman GC, Barati MT, Ward RA, Nauseef WM, McLeish KR. Granule exocytosis contributes to priming and activation of the human neutrophil respiratory burst. J Immunol. 2011 Jul 1;187(1):391-400. doi: 10.4049/jimmunol.1003112. Epub 2011 Jun 3. PubMed PMID: 21642540; PubMed Central PMCID: PMC3582343.

• Luerman GC, Powell DW, Uriarte SM, Cummins TD, Merchant ML, Ward RA, McLeish KR. Identification of phosphoproteins associated with human neutrophil granules following chemotactic peptide stimulation. Mol Cell Proteomics. 2011 Mar;10(3):M110.001552. doi: 10.1074/mcp.M110.001552. Epub 2010 Nov 19. PubMed PMID: 21097543; PubMed Central PMCID: PMC3047147.

• Luerman GC, Uriarte SM, Rane MJ, McLeish KR. Application of proteomics to neutrophil biology. J Proteomics. 2010 Jan 3;73(3):552-61. doi: 10.1016/j.jprot.2009.06.013. Epub 2009 Jul 4. Review. PubMed PMID: 19580889; PubMed Central PMCID: PMC2818037.