Eleanor D. Lederer, M.D., FASN

Eleanor D. Lederer, M.D., FASN Professor of Medicine Chief, Division of Nephrology Director, Nephrology Training Program Interim Chief of Medical Services, Robley Rex Veterans Affairs Medical Center University of Louisville Health Care Outpatient Center 401 East Chestnut Street, Ste. 690 Louisville, KY 40202 502-852-5757 - Academic Office 502-813-6699 - Patient Appointments

Clinical Expertise

Nephrology; Transplant; Kidney Stones

Board Certifications

• American Board of Internal Medicine - Internal Medicine / Nephrology

Education and Training

• Medical School: Baylor College of Medicine

• Residency: Baylor College of Medicine

• Fellowship: Baylor College of Medicine

Recent Publications

• Lederer E, Levi M. The flux of phosphate: rapid evolution. Adv Chronic Kidney Dis. 2011 Mar;18(2):61-2.

• Salyer S, Lesousky N, Weinman EJ, Clark BJ, Lederer ED, Khundmiri SJ. Dopamine regulation of Na+-K+-ATPase requires the PDZ-2 domain of sodium hydrogen regulatory factor-1 (NHERF-1) in opossum kidney cells. Am J Physiol Cell Physiol. 2011 Mar;300(3):C425-34. Epub 2010 Dec 15.

• Sen U, Givvimani S, Abe OA, Lederer ED, Tyagi SC. Cystathionine β-synthase and cystathionine γ-lyase double gene transfer ameliorate homocysteine-mediated mesangial inflammation through hydrogen sulfide generation. Am J Physiol Cell Physiol. 2011 Jan;300(1):C155-63. Epub 2010 Oct 13.

• Ahmad A, Khundmiri SJ, Pribble F, Merchant ML, Ameen M, Klein JB, Levi M, Lederer ED. Role of vacuolar ATPase in the trafficking of renal type IIa sodium-phosphate cotransporter. Cell Physiol Biochem. 2011;27(6):703-14. Epub 2011 Jun 17.

• Holthouser KA, Mandal A, Merchant ML, Schelling JR, Delamere NA, Valdes RR Jr, Tyagi SC, Lederer ED, Khundmiri SJ. Ouabain stimulates Na-K-ATPase through a sodium/hydrogen exchanger-1 (NHE-1)-dependent mechanism in human kidney proximal tubule cells. Am J Physiol Renal Physiol. 2010 Jul;299(1):F77-90. Epub 2010 Apr 28.

• Rosner MH, Berns JS, Parker M, Tolwani A, Bailey J, DiGiovanni S, Lederer E, Norby S, Plumb TJ, Qian Q, Yeun J, Hawley JL, Owens S; ASN In-Training Examination Committee. Development, implementation, and results of the ASN in-training examination for fellows. Clin J Am Soc Nephrol. 2010 Feb;5(2):328-34. Epub 2009 Dec 3.

• Chen YC, Meier RK, Zheng S, Khundmiri SJ, Tseng MT, Lederer ED, Epstein PN, Clark BJ. Steroidogenic acute regulatory-related lipid transfer domain protein 5 localization and regulation in renal tubules. Am J Physiol Renal Physiol. 2009 Aug;297(2):F380-8. Epub 2009 May 27.

• Merchant ML, Cummins TD, Wilkey DW, Salyer SA, Powell DW, Klein JB, Lederer ED. Proteomic analysis of renal calculi indicates an important role for inflammatory processes in calcium stone formation. Am J Physiol Renal Physiol. 2008 Oct;295(4):F1254-8. Epub 2008 Aug 13.

• Khundmiri SJ, Ameen M, Delamere NA, Lederer ED. PTH-mediated regulation of Na+-K+-ATPase requires Src kinase-dependent ERK phosphorylation. Am J Physiol Renal Physiol. 2008 Aug;295(2):F426-37. Epub 2008 Jun 11.

• Khundmiri SJ, Ahmad A, Bennett RE, Weinman EJ, Steplock D, Cole J, Baumann PD, Lewis J, Singh S, Clark BJ, Lederer ED. Novel regulatory function for NHERF-1 in Npt2a transcription. Am J Physiol Renal Physiol. 2008 Apr;294(4):F840-9. Epub 2008 Jan 23.