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Department of Medicine

Eleanor D. Lederer, M.D., FASN

by Puckett,Paul J — last modified Apr 17, 2013 09:58 AM

Eleanor D. Lederer, M.D., FASN





Eleanor D. Lederer, M.D., FASN

  • Professor of Medicine
  • Chief, Division of Nephrology
  • Director, Nephrology Training Program
University of Louisville Health Care Outpatient Center
401 East Chestnut Street, Ste. 690
Louisville, KY 40202

502-852-5757 - Academic Office
502-813-6699 - Patient Appointments



ULP - Kidney Disease Program

Clinical Expertise

Nephrology; Transplant; Kidney Stones; Genetic Kidney Disease; High Risk Pregnancy


Board Certifications

  • American Board of Internal Medicine - Internal Medicine / Nephrology


Education and Training

  • Medical School: Baylor College of Medicine

  • Residency: Baylor College of Medicine

  • Fellowship: Baylor College of Medicine


Recent Publications

  • Murray R, Holthouser K, Clark BJ, Salyer SA, Barati MT, Khundmiri SJ, Lederer  ED. Parathyroid Hormone (PTH) Decreases Sodium-Phosphate Cotransporter Type IIa (NpT2a) mRNA Stability. Am J Physiol Renal Physiol. 2013 Jan 23. [Epub ahead of print] PubMed PMID: 23344572.

  • Lederer ED, Klein JB. New treatments for CKD--new insights into pathogenesis. J Am Soc Nephrol. 2012 Oct;23(10):1601-3. Epub 2012 Sep 13. PubMed PMID: 22975668; PubMed Central PMCID: PMC3458472.

  • Weinman EJ, Lederer ED. NHERF-1 and the regulation of renal phosphate reabsoption: a tale of three hormones. Am J Physiol Renal Physiol. 2012 Aug 1;303(3):F321-7. doi: 10.1152/ajprenal.00093.2012. Epub 2012 Apr 25. PubMed PMID: 22535796; PubMed Central PMCID: PMC3433861.

  • Lederer E, Miyamoto K. Clinical consequences of mutations in sodium phosphate cotransporters. Clin J Am Soc Nephrol. 2012 Jul;7(7):1179-87. doi: 10.2215/CJN.09090911. Epub 2012 Apr 19. Review. PubMed PMID: 22516291.

  • Weinman EJ, Lederer ED. PTH-mediated inhibition of the renal transport of phosphate. Exp Cell Res. 2012 May 15;318(9):1027-32. doi: 10.1016/j.yexcr.2012.02.037. Epub 2012 Mar 5. Review. PubMed PMID: 22417892; PubMed Central PMCID: PMC3334409.

  • Lederer E, Levi M. The flux of phosphate: rapid evolution. Adv Chronic Kidney Dis. 2011 Mar;18(2):61-2. doi: 10.1053/j.ackd.2011.02.001. PubMed PMID: 21406289.

  • Salyer S, Lesousky N, Weinman EJ, Clark BJ, Lederer ED, Khundmiri SJ. Dopamine regulation of Na+-K+-ATPase requires the PDZ-2 domain of sodium hydrogen regulatory factor-1 (NHERF-1) in opossum kidney cells. Am J Physiol Cell Physiol. 2011 Mar;300(3):C425-34. doi: 10.1152/ajpcell.00357.2010. Epub 2010 Dec 15. PubMed PMID: 21160026; PubMed Central PMCID: PMC3063973.

  • Sen U, Givvimani S, Abe OA, Lederer ED, Tyagi SC. Cystathionine β-synthase and cystathionine γ-lyase double gene transfer ameliorate homocysteine-mediated mesangial inflammation through hydrogen sulfide generation. Am J Physiol Cell Physiol. 2011 Jan;300(1):C155-63. doi: 10.1152/ajpcell.00143.2010. Epub 2010 Oct 13. PubMed PMID: 20943958; PubMed Central PMCID: PMC3023186.

  • Ahmad A, Khundmiri SJ, Pribble F, Merchant ML, Ameen M, Klein JB, Levi M, Lederer ED. Role of vacuolar ATPase in the trafficking of renal type IIa sodium-phosphate cotransporter. Cell Physiol Biochem. 2011;27(6):703-14. doi: 10.1159/000330079. Epub 2011 Jun 17. PubMed PMID: 21691088; PubMed Central PMCID: PMC3221272.

  • Holthouser KA, Mandal A, Merchant ML, Schelling JR, Delamere NA, Valdes RR Jr, Tyagi SC, Lederer ED, Khundmiri SJ. Ouabain stimulates Na-K-ATPase through a sodium/hydrogen exchanger-1 (NHE-1)-dependent mechanism in human kidney proximal tubule cells. Am J Physiol Renal Physiol. 2010 Jul;299(1):F77-90. doi: 10.1152/ajprenal.00581.2009. Epub 2010 Apr 28. PubMed PMID: 20427472; PubMed Central PMCID: PMC2904182.

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