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Craig McClain

by dasamw01 — last modified Jan 31, 2013 09:53 AM

Craig J. McClain, M.D.





Craig J. McClain, M.D.

  • Professor of Medicine, Pharmacology and Toxicology
  • Chief of Research Affairs, Division of Gastroenterology, Hepatology and Nutrition
  • Associate Vice President for Translational Research
  • Associate Director, Fellowship Training Program
  • Distinguished University Scholar
University of Louisville Health Care Outpatient Center
401 East Chestnut Street, Ste. 310
Louisville, KY 40202

502-852-7963 - Academic Office
502-813-6500 - Patient Appointments

Clinical Expertise

General Hepatology, Transplant Hepatology, Nutrition, Alcoholic Liver Disease, Non-Alcoholic Steatohepatitis


Board Certifications

  • American Board of Internal Medicine - Internal Medicine / Gastroenterology

  • Certification Board for Nutrition Specialists

  • American Board of Physician Nutrition Specialists

 

Education and Training

  • Medical School: University of Tennessee

  • Residency: University of Pittsburgh Hospitals

  • Fellowship: University of Minnesota Hospitals


Recent Publications

  • Watson WH, Song Z, Kirpich IA, Deaciuc IV, Chen T, McClain CJ. Ethanol exposure modulates hepatic S-adenosylmethionine and S-adenosylhomocysteine levels in the isolated perfused rat liver through changes in the redox state of the NADH/NAD(+) system. Biochim Biophys Acta. 2011 May;1812(5):613-8. Epub 2011 Feb 2.

  • McClain CJ, Barve SS, Barve A, Marsano L. Alcoholic liver disease and malnutrition. Alcohol Clin Exp Res. 2011 May;35(5):815-20. doi: 10.1111/j.1530-0277.2010.01405.x. Epub 2011 Feb 1.

  • Beier JI, Arteel GE, McClain CJ. Advances in alcoholic liver disease. Curr Gastroenterol Rep. 2011 Feb;13(1):56-64.

  • Frazier TH, Stocker AM, Kershner NA, Marsano LS, McClain CJ. Treatment of alcoholic liver disease. Therap Adv Gastroenterol. 2011 Jan;4(1):63-81.

  • Gobejishvili L, Avila DV, Barker DF, Ghare S, Henderson D, Brock GN, Kirpich IA, Joshi-Barve S, Mokshagundam SP, McClain CJ, Barve S. S-adenosylmethionine decreases lipopolysaccharide-induced phosphodiesterase 4B2 and attenuates tumor necrosis factor expression via cAMP/protein kinase A pathway. J Pharmacol Exp Ther. 2011 May;337(2):433-43. Epub 2011 Jan 25.

  • Kirpich IA, Gobejishvili LN, Bon Homme M, Waigel S, Cave M, Arteel G, Barve SS, McClain CJ, Deaciuc IV. Integrated hepatic transcriptome and proteome analysis of mice with high-fat diet-induced nonalcoholic fatty liver disease. J Nutr Biochem. 2011 Jan;22(1):38-45. Epub 2010 Mar 20.

  • Frazier TH, Stocker AM, Kershner NA, Marsano LS, McClain CJ. Treatment of alcoholic liver disease. Therap Adv Gastroenterol. 2011 Jan;4(1):63-81.

  • Cave M, Appana S, Patel M, Falkner KC, McClain CJ, Brock G. Polychlorinated biphenyls, lead, and mercury are associated with liver disease in American adults: NHANES 2003-2004. Environ Health Perspect. 2010 Dec;118(12):1735-42.

  • Barve S, Kapoor R, Moghe A, Ramirez JA, Eaton JW, Gobejishvili L, Joshi-Barve S, McClain CJ.  Focus on the Liver: Alcohol Use, Highly Active Antiretroviral Therapy, and Liver Disease in HIV-Infected Patients. Alcohol Research & Health, 33(3):229-236, 2010.

  • Beier JI, McClain CJ. Mechanisms and cell signaling in alcoholic liver disease. Biol Chem. 2010 Nov;391(11):1249-64. Review.

  • Zhong W, Zhao Y, McClain CJ, Kang YJ, Zhou Z. Inactivation of hepatocyte nuclear factor-4{alpha} mediates alcohol-induced downregulation of intestinal tight junction proteins. Am J Physiol Gastrointest Liver Physiol. 2010 Sep;299(3):G643-51. Epub 2010 Jun 24.

  • Zhong W, McClain CJ, Cave M, Kang YJ, Zhou Z. The role of zinc deficiency in alcohol-induced intestinal barrier dysfunction. Am J Physiol Gastrointest Liver Physiol. 2010 May;298(5):G625-33. Epub 2010 Feb 18.

  • Patel M, McClain C, Marsano L.  Alcoholic Liver  Disease Diagnosis and Treatment.  BMJ Publishing Group, 2009. https://online.epocrates.com/u/29611116/Alcoholic+liver+disease.  Epocrates, Inc. and BMJ Publishing Group, Ltd.

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