Walter H. Watson, Ph.D.

Walter H. Watson, Ph.D. Assistant Professor 502-852-7963 - Academic Office

Education

• B.A. (Chemistry): Emory University

• Ph.D. (Toxicology): University of Kentucky

Research Interests

• Oxidative stress and redox signaling

• Mechanistic toxicology

• Alcoholic and nonalcoholic fatty liver disease

Recent Publications

• Scarbrough PM, Mapuskar KA, Mattson DM, Gius D, Watson WH, Spitz DR. Simultaneous inhibition of glutathione- and thioredoxin-dependent metabolism is necessary to potentiate 17AAG-induced cancer cell killing via oxidative stress. Free Radic Biol Med. 2012 Jan 15;52(2):436-43.

• Tan M, Schmidt RH, Beier JI, Watson WH, Zhong H, States JC, Arteel GE. Chronic subhepatotoxic exposure to arsenic enhances hepatic injury caused by high fat diet in mice. Toxicol Appl Pharmacol. 2011 Dec 15;257(3):356-64.

• Lai IK, Chai Y, Simmons D, Watson WH, Tan R, Haschek WM, Wang K, Wang B, Ludewig G, Robertson LW. Dietary selenium as a modulator of PCB 126-induced hepatotoxicity in male Sprague-Dawley rats. Toxicol Sci. 2011 Nov;124(1):202-14.

• Heilman JM, Burke TJ, McClain CJ, Watson WH. Transactivation of gene expression by NF-κB is dependent on thioredoxin reductase activity. Free Radic Biol Med. 2011 Oct 15;51(8):1533-42.

• Stanley BA, Sivakumaran V, Shi S, McDonald I, Lloyd D, Watson WH, Aon MA, Paolocci N. Thioredoxin reductase-2 is essential for keeping low levels of H(2)O(2) emission from isolated heart mitochondria. J Biol Chem. 2011 Sep 23;286(38):33669-77.

• Watson WH, Song Z, Kirpich IA, Deaciuc IV, Chen T, McClain CJ. Ethanol exposure modulates hepatic S-adenosylmethionine and S-adenosylhomocysteine levels in the isolated perfused rat liver through changes in the redox state of the NADH/NAD(+) system. Biochim Biophys Acta. 2011 May;1812(5):613-8.

• Singh A, Ling G, Suhasini AN, Zhang P, Yamamoto M, Navas-Acien A, Cosgrove G, Tuder RM, Kensler TW, Watson WH, Biswal S. Nrf2-dependent sulfiredoxin-1 expression protects against cigarette smoke-induced oxidative stress in lungs. Free Radic Biol Med. 2009 Feb 1;46(3):376-86.

• Singh A, Boldin-Adamsky S, Thimmulappa RK, Rath SK, Ashush H, Coulter J, Blackford A, Goodman SN, Bunz F, Watson WH, Gabrielson E, Feinstein E, Biswal S. RNAi-mediated silencing of nuclear factor erythroid-2-related factor 2 gene expression in non-small cell lung cancer inhibits tumor growth and increases efficacy of chemotherapy. Cancer Res. 2008 Oct 1;68(19):7975-84.

• Spielberger JC, Moody AD, Watson WH. Oxidation and nuclear localization of thioredoxin-1 in sparse cell cultures. J Cell Biochem. 2008 Aug 1;104(5):1879-89.

• Traore K, Sharma R, Thimmulappa RK, Watson WH, Biswal S, Trush MA. Redox-regulation of Erk1/2-directed phosphatase by reactive oxygen species: role in signaling TPA-induced growth arrest in ML-1 cells. J Cell Physiol. 2008 Jul;216(1):276-85.