Wenke Feng, Ph.D.

Wenke Feng, Ph.D. Assistant Professor 502-852-7963 - Academic Office

Education

• B.Sc.: Shaanxi Normal University (Xi'an, China)

• M.Sc.: Northwest University (Xi'an, China)

• Ph.D.: Universitaet fuer Bodenkultur (Vienna, Austria)

Research Interests

• Mechanisms of alcoholic liver disease

• Mechanisms of nonalcoholic steatohepatitis 

• Tissue hypoxia and diabetic complications

Recent Publications

• Kirpich IA, Feng W, Wang Y, Liu Y, Barker DF, Barve SS, McClain CJ. The Type of Dietary Fat Modulates Intestinal Tight Junction Integrity, Gut Permeability, and Hepatic Toll-Like Receptor Expression in a Mouse Model of Alcoholic Liver Disease. Alcohol Clin Exp Res. 2011 Dec 7. doi: 10.1111/j.1530-0277.2011.01673.x.

• Wang Y, Kirpich I, Liu Y, Ma Z, Barve S, McClain CJ, Feng W. Lactobacillus rhamnosus GG treatment potentiates intestinal hypoxia-inducible factor, promotes intestinal integrity and ameliorates alcohol-induced liver injury. Am J Pathol. 2011 Dec;179(6):2866-75.

• Lin Z, Zhou Z, Liu Y, Gong Q, Yan X, Xiao J, Wang X, Lin S, Feng W, Li X. Circulating FGF21 levels are progressively increased from the early to end stages of chronic kidney diseases and are associated with renal function in Chinese. PLoS One. 2011 Apr 15;6(4):e18398.

• Lin Z, Wu Z, Yin X, Liu Y, Yan X, Lin S, Xiao J, Wang X, Feng W, Li X. Serum levels of FGF-21 are increased in coronary heart disease patients and are independently associated with adverse lipid profile. PLoS One. 2010 Dec 29;5(12):e15534.

• Xue W, Cai L, Tan Y, Thistlethwaite P, Kang YJ, Li X, Feng W. Cardiac-specific overexpression of HIF-1{alpha} prevents deterioration of glycolytic pathway and cardiac remodeling in streptozotocin-induced diabetic mice. Am J Pathol. 2010 Jul;177(1):97-105.

• Xiao J, Lv Y, Lin S, Jin L, Zhang Y, Wang X, Ma J, Hu K, Feng W, Cai L, Li X, Tan Y. Cardiac protection by basic fibroblast growth factor from ischemia/reperfusion-induced injury in diabetic rats. Biol Pharm Bull. 2010;33(3):444-9.

• Liu Q, Wang G, Zhou G, Tan Y, Wang X, Wei W, Liu L, Xue W, Feng W, Cai L. Angiotensin II-induced p53-dependent cardiac apoptotic cell death: its prevention by metallothionein. Toxicol Lett. 2009 Dec 15;191(2-3):314-20.

• Huang Z, Ni C, Zhou X, Liu Y, Tan Y, Xiao J, Feng W, Li X, Yang S. Mechanism of pH-sensitive polymer-assisted protein refolding and its application in TGF-beta1 and KGF-2. Biotechnol Prog. 2009 Sep-Oct;25(5):1387-95.

• Huang Z, Ni C, Chu Y, Wang S, Yang S, Wu X, Wang X, Li X, Feng W, Lin S. Chemical modification of recombinant human keratinocyte growth factor 2 with polyethylene glycol improves biostability and reduces animal immunogenicity. J Biotechnol. 2009 Jul 15;142(3-4):242-9.

• Xue W, Liu Q, Cai L, Wang Z, Feng W. Stable overexpression of human metallothionein-IIA in a heart-derived cell line confers oxidative protection. Toxicol Lett. 2009 Jul 10;188(1):70-6.