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Division of Gastroenterology/Hepatology

Matthew Cave, M.D. Assistant Professor Division of Gastroenterology/Hepatology University of Louisville School of Medicine Louisville, Kentucky 40292 502 852-6189 502 852-8927 Fax matt.cave@louisville.edu

 

Education: 

    MD, University of Kentucky
    BS Chemical Engineering, Rice University
    BA Biochemistry, Rice University

Training: 

    Gastroenterology & Hepatology, University of Louisville
    Internal Medicine, Washington University in St. Louis

Research Interests: 

• Steatohepatitis and liver cancer related to environmental and occupational chemical exposures
• Complementary and alternative medicine in liver disease
• Alcoholic and nonalcoholic fatty liver disease
• Hepatitis c treatment
  
  

Clinical Interests: 

• Hepatology
• Nutrition
• Liver transplantation

 

Recent Publications:

 

• Kirpich, I., Solovieva, N., Leikhter, S., Shidakova, N., Lebedeva, O., Sidorov, P., Bazhukova, T., Soloviev, A., Barve, S., McClain, C.J., Cave, M. Probiotics Normalize Bowel Flora and Improve Liver Enzymes in Alcohol Induced Liver Injury: A Pilot Study.  Alcohol. 2008; 42(8):675-82.
• Sozio, M., Cave, M. Boerhaave’s Syndrome Following Chiropractic Manipulation. American Surgeon. 2008; 74(5):428-9.
• Cave, M., Hurt, R.T., Frazier, T., Matheson, P., Garrison, N, McClain, C.J., McClave, S. Obesity, Inflammation and the Potential Application of Pharmaconutrition. Nutrition in Clinical Practice. 2008;23(1):16-34.
• Hurt, R.T., Frazier, T., Matheson, P, Cave, M., Garrison, N., McClain, C.J., McClave, S. Obesity and Inflammation.  Should the Principles of Immunonutrition be Applied to this Disease Process?  Current Gastroenterology Reports.  2007; 9(4): 305-308.
• Joshi-Barve, S., Barve, S., Amancherla, K., Gobejishvili, L., Hill, D., Cave, M., Hote, P.  McClain C.J.  Palmitic Acid Induces Production of Proinflammatory Cytokine Interleukin-8 from Hepatocytes.  Hepatology.  2007; 46(3):823-830.
• Cave, M., Deaciuc, I., Mendez, C., Song, Z., Joshi-Barve, S., Barve, S., McClain, C.J. Non-alcoholic Fatty Liver Disease: Predisposing Factors and the Role of Nutrition. J Nutr Biochem. 2007; 18(3):184-195.
  

Mini Bio:
I am a native of Frankfort, KY and studied chemical engineering and biochemistry at Rice University prior to returning home for medical school at the University of Kentucky.  After graduation, I completed an internal medicine residency at Washington University in St. Louis and subsequently a fellowship in gastroenterology and hepatology at the University of Louisville.  Under the mentorship of Dr. Craig McClain, I am developing a research program in occupational & environmental liver disease as well as alcoholic liver disease.  I currently have research funding through the AASLD (Sheila Sherlock Award) and the NIH through pilot projects in the UofL Alcohol Research Center and the Center for Environmental Genomics and Integrative Biology.  My current work focuses on vinyl chloride induced hepatic hemangiosarcoma and toxicant-associated steatohepatitis (TASH); as well as liver disease medicated by common environmental pollutants such as pesticides, heavy metals, and PCBs.  I am also the principal investigator for several pharmaceutical company sponsored hepatitis C treatment clinical trials at the University of Louisville.