Laboratory Research
Laboratory
Our Laboratory focuses on molecular mechanisms of cell death in the heart and liver under oxidative stress conditions, developing strategies to inhibit oxidative tissue pathogenesis, and inventing novel therapeutic approaches to tissue regeneration.Cell death is the ultimate cellular event leading to pathogenesis. To rescue tissues at risk under different disease conditions, treatment strategies would include inhibition of cell death, redirecting the cell death program to re-entry into cell cycle, and eventually tissue regeneration.
We established a functional proteomics and a gene therapy facility in addition to our existing molecular biology, immunohistochemistry, cell cultures, cardiac physiology, and biochemical and chemical analysis facilities. We have also established new collaborations within and outside of the University. Our strategy is to quickly acquire new information through bioinformatics, providing comprehensive understanding of functional molecules and their interactions in response to physical and chemical insults through functional genomics and proteomics approaches, and to eventually identify essential molecules for the development of novel interventions via gene therapy. Our goal is to provide a more comprehensive understanding of cellular dynamics under different conditions with an emphasis on oxidative signaling, cell death programs, and re-entry to cell cycle. These multi-disciplinary approaches aim at establishing a systems biology study of tissue regeneration, leading to Regenerative Medicine.
