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Sham S. Kakar, Ph. D.
Appointments
- Professor of Medicine
- Professor of Physiology and Biophysics
- Professor of Biochemistry and Molecular Biology
Departments
Location
Phone Number
- 502-852-0812
Email Address
Website
Bio
Dr. Kakar joined the University of Louisville faculty in 2000. He also serves as a senior scientist for the James Graham Brown Cancer Center. He is a member of the American Association for the Advancement of Science, American Association for Biochemistry and Molecular Biology, The Endocrine Society, American Association for Cancer Research, and International Society of Oxygen Transport to Tissues (ISOTT). He is a grant reviewer for internal grants for James Brown Cancer Center, and a special external grant reviewer for British Columbia Research Institute for Children’s & Women’s Health. He is Editor in Chief for the "Journal of Ovarian Research." His research is focused on the molecular analysis of the structure and function of the gonadotropin releasing hormone (GnRH) receptor in tumors and molecular characterization of the tumor transforming gene/PTTG.
Educational Background
- Ph.D., Biochemistry,National Dairy Research Institute Karnal, India. Kurukshetra University, 1983
- M.S., Biochemistry,National Dairy Research Institute Karnal,India. Kurukshetra University, 1975.
- B.S., Chemistry,Mathematics and Physics with Honor in Mathematics, Punjab University. Chandigarh, India, 1973.
Research Interests
- Hormones and Cancer
- GnRH Receptors in Tumors
- Tumor transforming gene/PTTG
Publications
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Recent Publications
Shahenda M. El-Naggar, Mohhamad T. Malik, Alvin Martin, Joseph P. Moore, Marry Proctor, Tariq Hamid and Sham S. Kakar (2007) Development of cystic glandular hyperplasia of the endometrium in MISIIR- PTTG transgenic mice. Journal of Endocrinology. 194 (1): 179-191.
Shahenda El-Naggar, Mohammed T. Malik and Sham S. Kakar (2007). Small interfering RNA against PTTG: A novel therapy for ovarian cancer. International Journal of oncology. 31(1): 137-143.
Stephen J. Winters, Dushan Ghooray, Yasuhisa Fusii, Joseph P. Moore Jr, Jennifer R. Nevitt and Sham S. Kakar (2007) GnRH activates follistatin through cyclic AMP signaling. Molecular and Cellular Endocrinology. 271(1,2): 45-54.
Christi Bradshaw and Sham S. Kakar (2007) Pituitary Tumor Transforming Gene: An Important Gene in Normal Cellular Functions and Tumorigenesis. Histol. Histopath. 22: 219-226.
Sham S. Kakar, Hanzhu Jin, Bin Hong, John W. Eaton, Kyung A. Kang (2008) LHRH targeted therapy for breast cancer. Adv Exp Med Biol. 614: 285-296.
