Tel.: (502) 852-7959 (ACB);  587-4500 (JHHL)
E-mail: Buddha@louisville.edu













Dr. Dawn’s research focuses on the protection of myocardium against ischemic injury. Specifically, his research involves deciphering the roles of nitric oxide and nuclear factor kappaB (NF-kappaB), a stress-responsive transcription factor present virtually in all cells, in the genesis and mediation of the late phase of preconditioning. Dr. Dawn’s research also involves characterization of cytokine (TNF-alpha and IL-6) signaling in myocardial ischemia/reperfusion injury and in the development of late PC. More recently, Dr. Dawn has acquired extensive expertise in the areas of stem cell biology, fluorescent immunohistochemistry, cardiac pathology, echocardiography in small animals, and stem cell-mediated approaches of myocardial regeneration following myocardial infarction. Several ongoing studies are currently evaluating the feasibility and optimizing the efficacy of myocardial repair via local/systemic delivery of different adult stem cell populations.

Selected Publications:  

Bolli R, Dawn B, Tang X-L, Qiu Y, Ping P, Xuan Y-T, Jones WK, Takano H, Guo Y, Zhang J. The nitric oxide hypothesis of late preconditioning. Basic Res Cardiol 1998;93:325-338.

Dawn B, Xuan YT, Qiu Y, Tang X-L, Takano H, Ping P, Banerjee S, Hill M, Bolli R. Bifunctional role of protein tyrosine kinases in late preconditioning against myocardial stunning in conscious rabbits. Circ Res 1999;85:1154-1163.

Dawn B, Xuan YT, Marian M, Flaherty MP, Murphree SS, Smith TL, Bolli R, Jones WK. Cardiac-specific abrogation of NF-kappaB activation in mice by transdominant expression of a mutant IkappaBalpha. J Mol Cell Cardiol 2001;33:161-173.

Dawn B, Bolli R. Role of nitric oxide in myocardial preconditioning. Ann NY Acad Sci 2002;962:18-41.