Division of Cardiovascular Medicine

Xian-Liang Tang, M.D.

Associate Professor of Medicine

Tel.: (502) 852-4539

E-mail : xltang@louisville.edu

Dr. Tang completed a Research Fellowship at Baylor College of Medicine in Dr. Bolli’s lab.  He is a well-trained pharmacologist and physiologist, who is also actively involved in studying the phenomenon of ischemic preconditioning in conscious rabbits, conscious pigs, open chest mice, isolated hearts, and other physiological models.  Dr. Tang’s research interests focus upon the mechanism of ischemic preconditioning (PC) and myocardial gene therapy using conscious rabbits, conscious rats, and open chest mouse models.  Ischemic PC is the phenomenon whereby brief episodes of ischemia render the myocardium resistant to subsequent ischemic/reperfused injury via mechanisms currently unknown.  Current research is focused upon testing the hypothesis that nitric oxide plays a dual role in both triggering and in mediating the cardioprotective effects of ischemic PC.  The studies that we have done or are doing included:  (1) demonstrating the late phase of ischemic preconditioning against myocardial stunning and infarction;  (2) investigating the mechanisms underlying ischemic preconditioning; (3) investigating the late preconditioning phenomenon under pathological conditions such as hypercholesterolemia and atherosclerosis; and (4) myocardial regeneration using cardiac stem cells.  The overall goal of Dr. Tang’s research is to elucidate the mechanism underlying  ischemic/reperfused myocardial injury and to explore novel strategies for myocardial protection in patients at risk.

Selected Publications:

•  Tang XL, Qiu Y, Park SW, Sun JZ, Kalya A, Bolli R. Time course of late preconditioning against myocardial stunning in conscious pigs. Circ Res. 79:424-34,1996. ( Full text in htm file )

• Sun JZ, Tang XL, Park SW, Qiu Y, Turrens JF, Bolli R. Evidence for an essential role of reactive oxygen species in the genesis of late preconditioning against myocardial stunning in conscious pigs. J Clin Invest. 97:562-76,1996. ( Full text in PDF file )

• Tang X-L, Qiu Y, Turrens JF, Sun JZ, and Bolli R.    Late preconditioning against stunning is not mediated by increased antioxidant defenses in conscious pigs.  Am. J. Physiol.  273:H1651-H1657, 1997. ( Full text in PDF file )

•  Takano H, Manchikalapudi S, Tang X-L, Qiu Y, Rizvi A, Jadoon AK, Zhang Q, and Bolli R.    Nitric oxide synthase is the mediator of the late phase of preconditioning against myocardial infarction in conscious rabbits.  Circulation .  98:441-449, 1998. (Full text in PDF file )

• Takano H, Tang XL, Qiu Y, Guo Y, French BA, Bolli R. Nitric oxide donors induce late preconditioning against myocardial stunning and infarction in conscious rabbits via an antioxidant- sensitive mechanism. Circ Res. 83:73-84, 1998.( Full text in PDF file )

• Guo Y, Wu WJ, Qiu Y, Tang XL, Yang Z, Bolli R. Demonstration of an early and a late phase of ischemic preconditioning in mice. Am J Physiol. 275:H1375-H1387, 1998. ( Full text in PDF file )

• Rizvi A, Tang XL, Qiu Y, Xuan YT, Takano H, Jadoon AK, Bolli R.  Increased protein synthesis is necessary for development of late preconditioning against myocardial stunning. Am J  Physiol 277:H874-H884, 1999. ( Full text in PDF file )

• Banerjee S, Tang XL, Qiu Y, Takano H, Manchikalapudi S, Dawn B, Bolli R.  Nitroglycerin induces late preconditioning against myocardial stunning via a protein kinase dependent pathway.  Am J Physiol  277:H2488-H2494, 1999. ( Full text in PDF file )

• Shinmura K, Tang XL, Takano H, Hill M, Bolli R.  Nitric oxide donors attenuate myocardial stunning in conscious rabbits. Am J Physiol 277:H2495-H2503, 1999.  ( Full text in PDF file )

• Takano H, Tang XL, Bolli R. Differential role of KATP channels in late preconditioning against myocardial stunning and infarction in rabbits.  Am J Physiol   279:H2350-H2359, 2000. (Full text in PDF file )

• Takano H, Tang XL, Kodani E, Bolli R. Late preconditioning enhances recovery of myocardial function after infarction in conscious rabbits.  Am J Physiol    279:H2372-H2381, 2000. (Full text in PDF file )

• Shinmura K, Tang XL, Wang Y, Xuan YT, Liu SQ, Takano H, Bhatnagar A, Bolli R. Cyclooxygenase-2 mediates the cardioprotective effects of the late phase of ischemic preconditioning in conscious rabbits [In Process Citation].  Proc Natl Acad Sci U S A.    97:10197-10202, 2000. (Full text in PDF file )

• Xuan YT, Tang XL, Qiu Y, Banerjee S, Takano H, Han H, Bolli R. Biphasic response of cardiac NO synthase to ischemic preconditioning in conscious rabbits.  Am J Physiol   279:H2360-H2371, 2000. ( Full text in PDF file )

• Tang XL, Takano H, Rizvi A,  Turrens JF, Qiu Y, Wu WJ, Zhang Q, and Bolli R. Oxidant species trigger late preconditioning against myocardial stunning in conscious rabbits Am J Physiol Heart Circ Physiol  282: H281-H291, 2002.  ( Full text in PDF file )

• Tang XL, Kodani E, Takano H, Hill M, Shinmura K, Vondriska TM, Ping P, Bolli R. Protein tyrosine kinase signaling is necessary for nitric oxide donor-induced late preconditioning against myocardial stunning.  Am J Physiol Heart Circ Physiol 284(4):H1441-H1448. 2003.

• Tang XL, Xuan YT, Zhu Y, Shirk G, and Bolli R. Nicorandil induces late preconditioning against myocardial infarction in conscious rabbits. Am J Physiol Heart Circ Physiol 286: H1273-1280, 2004.

• Tang XL, Stein AB, Shirk G, and Bolli R.  Hypercholesterolemia blunts NO donor-induced late preconditioning against myocardial infarction in conscious rabbits.  Submitted to Basic Res Cardiol. 2004 Nov;99(6):395-403