Matthew Spite, PhD

Assistant Professor of Medicine

Tel. 502-852-7215

Email: Matthew.spite@louisville.edu

Research Interests

Inflammation is an underlying component of many prominent diseases, including atherosclerosis and diabetes. The major thrust of our research is to understand the mechanisms by which acute inflammation resolves in order to understand how these pathways could become modulated with the progression of chronic inflammatory diseases.  In particular, we are interested in the role of endogenous lipid mediators, such as the lipoxins and resolvins, in actively regulating the resolution of inflammation. Our long term goal is to determine if pro-resolution lipid mediators could serve as biotemplates for the development of novel therapeutics for treating cardiovascular disease.

Representative Publications

Spite M, Norling LV, Summers L, Yang R, Cooper D, Petasis NA, Flower RJ, Perretti M, Serhan CN, Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis.  Nature  461:1287-1291, 2009

Serhan CN, Yang R, Martinod K, Kasuga K, Pillai PS, Porter TF, Oh SF, Spite M., Maresins: novel macrophage mediators with potent anti-inflammatory and pro-resolving actions. J. Exp. Med. 206: 15-23, 2009

Srivastava S, Vladykovskaya E,  Barski OA, Spite M,  Kaiserova K, Petrash JM, Chung SS, Hunt G, Dawn, B.,Bhatnagar A. Aldose reductase protects against early atherosclerotic lesion formation in apoE-null mice. Circ.Res. 105:793-802, 2009