Dr. Jones
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xltang
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May 17, 2011 05:58 PM
Associate Professor of Medicine Tel.: (502) 852-2460 E-mail: Steven.P.Jones@louisville.edu
Steven Jones, Ph.D.
Please Visit my Research Lab at: http://louisville.edu/research/joneslab/
Ph.D.: 1998-2002, Cardiovascular Physiology, LSU (Lefer)
Fellowship: 2002-2004, Mitochondrial Biology, JHU (Marban)
Assistant Professor: 2004-2009, UofL
Associate Professor: 2009-present, UofL
Goal:
To understand why myocytes die during acute myocardial infarction and heart failure and to develop strategies to prevent cell death.
Research Interests:
Although largely appreciated for the production of energy (via ATP), mitochondria have emerged as critical determinants of cell survival. My laboratory investigates the mechanisms of mitochondrial-mediated injury in the heart. My group is particularly interested in interfering with post-ischemic events in the mitochondria that damage the viability and function of cardiac muscle. With a more lucid understanding of mitochondrial biology within the context of the heart, we can create superior treatments to protect cardiac function subsequent to a heart attack and during heart failure.
Recent Publications
- 2011. Biochem J. (in press).
Sansbury BE, Riggs DW, Brainard RE, Salabei JK, Jones SP, Hill BG. Responses of hypertrophied myocytes to reactive species: implications for glycolysis and electrophile metabolism. 2011. Biochem J. (in press). - 2010. Chem Biol Interact. (in press).
Sansbury BE, Jones SP, Riggs DW, Darley-Usmar VM, Hill BG. Bioenergetic function in cardiovascular cells: The importance of the reserve capacity and its biological regulation. 2010. Chem Biol Interact. (in press). - 2010. Proc Natl Acad Sci USA. 107: 17797-17802.
Watson LJ, Facundo HT, Ngoh GA, Ameen M, Brainard RE, Lemma KM, Long BW, Prabhu SD, Xuan YT, Jones SP. O-linked β-N-acetylglucosamine transferase is indispensable in the failing heart. 2010. Proc Natl Acad Sci USA. 107: 17797-17802. - 2010 Amino Acids. August: 726-728.
Ngoh GA, Watson LJ, Facundo HT, Jones SP. Augmented O-GlcNAc Signaling attenuates oxidative stress and calcium overload in cardiomyocytes. Amino Acids. August 2010: 726-728. - 2010. Circulation Research. 107: 171-185.
Ngoh GA, Facundo HT, Zafir A, Jones SP. O-GlcNAc Signaling in the Cardiovascular System. 2010. Circulation Research. 107: 171-185. - 2010. J Pharmacol Exp Ther. 333: 696-706.
Schaller S, Paradis S, Ngoh GA, Assaly R, Buisson B, Drouot C, Ostuni MA, Lacapere JJ, Bassissi F, Bordet T, Berdeaux A, Jones SP, Morin D, Pruss RM. TRO40303 (3,5-seco-4-nor-cholestan-5-one oxime-3-ol), a new cardioprotective compound, inhibits mitochondrial permeability transition. 2010. J Pharmacol Exp Ther. 333: 696-706. - 2009. Am J Physiol Heart Circ Physiol. 297:H1711-9.
Ngoh GA, Hamid T, Prabhu SD, Jones SP. O-GlcNAc Signaling Attenuates ER Stress-Induced Cardiomyocyte Death. 2009. Am J Physiol Heart Circ Physiol. 297:H1711-9. - 2009. Circulation Research. 104: 282-284.
Facundo HT, Jones SP. AMP-dependent protein kinase activators: Not just for diabetes? 2009. Circulation Research. 104: 282-284. - 2009. Circulation Research. 104: 41-49.
Ngoh GA, Facundo HT, Hamid T, Dillmann W, Zachara NE, Jones SP. Unique Hexosaminidase Reduces Metabolic Survival Signal and Sensitizes Cardiac Myocytes to Hypoxia-Reoxygenation Injury. 2009. Circulation Research. 104: 41-49. *See associated editorial on page 7. - 2008. Journal of Pharmacology and Experimental Therapeutics. 327: 602-609
Ngoh GA, Jones SP. New insights into metabolic signaling and cell survival: the role of beta-O-linkage of N-acetylglucosamine. 2008. J Pharmacol Exp Therap. 327: 602-609. - 2008. Journal of Molecular and Cellular Cardiology. 45: 313-325.
Ngoh GA, Watson LJ, Facundo HT, Dillmann W, Jones SP. Noncanonical glycosyltransferase modulates post-hypoxic cardiac myocyte death and mitochondrial permeability transition. 2008. J Mol Cell Cardiol. 45: 313-325. - 2008. American Journal of Physiology. 294: H2889-H2897.
Wang Q, Donthi RV, Wang J, Watson LJ, Lange AJ, Jones SP, Epstein PN. Cardiac phosphatase deficient 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase increases glycolysis, hypertrophy, and myocyte resistance to hypoxia. 2008. Am J Physiol. 294: H2889-H2897. - 2008. Circulation. 117: 1172-1182.
Jones SP, Zachara NE, Ngoh GA, Hill BG, Teshima Y, Bhatnagar A, Hart GW, Marban E. Cardioprotection by N-acetylglucosamine linkage to cellular proteins. 2008. Circulation. 117: 1172-1182.
