Dr. Jones
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Sep 25, 2008 09:57 AM
Steven Jones, Ph.D.
Assistant Professor of Medicine
Tel.: (502) 852-2460
E-mail:
spjone04@louisville.edu
Please Visit my Research Lab at: https://louisville.edu/research/joneslab/
Ph.D.: 1998-2002, Cardiovascular Physiology, LSU (Lefer)
Fellowship: 2002-2004, Mitochondrial Biology, JHU (Marban)
Assistant Professor: 2004-present,
UofL
Goal:
To understand why myocytes die
during acute myocardial infarction and heart failure and to develop strategies
to prevent cell death.
Research Interests:
Although largely appreciated for the
production of energy (via ATP), mitochondria have emerged as critical
determinants of cell survival. My laboratory investigates the mechanisms of
mitochondrial-mediated injury in the heart. My group is particularly interested
in interfering with post-ischemic events in the mitochondria that damage the
viability and function of cardiac muscle. With a more lucid understanding of
mitochondrial biology within the context of the heart, we can create superior
treatments to protect cardiac function subsequent to a heart attack and during
heart failure.
Selected Publications:
"The ubiquitous role of nitric oxide in
cardioprotection". JMCC. 2006.
"A bittersweet modification: O-GlcNAc and cardiac
dysfunction". Circ Res. 2005.
"Deficiency of iNOS does not attenuate severe
congestive heart failure in mice". Am J Physiol. 2005.
"Endothelial nitric oxide synthase overexpression
attenuates myocardial reperfusion injury". Am J Physiol.
2004.
"Simvastatin attenuates oxidant-induced
mitochondrial dysfunction in cardiac myocytes". Circ Res.
2003.
"Uncoupling protein-2 overexpression inhibits
mitochondrial death pathway in cardiomyocytes". Circ Res.
2003.
"Endothelial nitric oxide synthase overexpression
attenuates congestive heart failure in mice". PNAS. 2003.
World’s first cardiac adult stem cell trial to take place in Louisville
