Division of Cardiovascular Medicine

Sanjay Srivastava, Ph.D.

Associate Professor of Medicine

Tel.: (502) 852-5834

E-mail: s0sriv01@louisville.edu

 Dr. Srivastava has a Ph.D. from Lucknow University, Lucknow, India.   His research interests include cardiovascular metabolism of oxidized lipids-derived aldehydes. Dr. Srivastava is working to delineate the mechanisms by which aldehydes induce/propagate atherogenesis. Moreover, he is also examining the molecular mechanism by which diabetes and environmental toxins exacerbate atherogenesis.

Recent Publications:

Baba SP, Barski OA, Ahmed Y, O'Toole TE, Conklin DJ, Bhatnagar A, Srivastava S. Reductive Metabolism of AGE Precursors: A Metabolic route for preventing AGE accumulation in cardiovascular tissue. Diabetes. 2009 (In Press).

Hill BG, Awe SO, Vladykovskaya E, Ahmed Y, Liu SQ, Bhatnagar A, Srivastava S. Myocardial ischaemia inhibits mitochondrial metabolism of 4-hydroxy-trans-2-nonenal. Biochem J. 417:513-24,2009.

Srivastava S., Vladykovskaya E., Barski O.A., Spite M., Kaiserova K., Petrash J.M., Chung S.S., Hunt G., Dawn B., and Bhatnagar A. Aldose reductase protects against early atherosclerotic lesion formation in apoE-null mice. Circ Res. (In Press).

Srivastava S., Vladykovskaya EN, Haberzettl P, Sithu SD, D'Souza SE, States JC. Arsenic exacerbates atherosclerotic lesion formation and inflammation in Apoe(-/-) mice. Toxicol Appl Pharmacol. 2009 (In Press).  

Reddy AB, Ramana KV, Srivastava S, Bhatnagar A, Srivastava SK. Aldose reductase regulates high glucose-induced ectodomain shedding of tumor necrosis factor (TNF)-alpha via protein kinase C-delta and TNF-alpha converting enzyme in vascular smooth muscle cells. Endocrinology 150:63-74,2009.