Dr. Jonathan Chaires
Professor of Medicine, James Graham Brown Chair in Cancer Biophysics
Email Dr. Chaires
Phone Number: 502-852-1172
Address: Room 428, James Graham Brown Cancer Center
University of Louisville, 529 S. Jackson St.
Louisville, KY 40202
BA, 1972, University of California at Santa Cruz
PhD, 1978, University of Connecticut
Area of Interest:My interests are in the physical biochemistry of nucleic acids and their interactions.
We develop novel technologies that facility the discovery of small molecules
that can bind selectively to unique DNA structures and sequences. In addition,
we have pioneered the use of calorimetry for characterizing the human plasma
proteome as a new tool for the rapid diagnosis of disease.
Laboratory Personnel:Dr. Nichola Garbett, Dr. Patricia Ragazzon, Dr. Robert Gray, Chongham Mekmaysey, Robert Buscaglia
Selected Publications:Bishop, G. R., Ren, J., Polander, B. C., Jeanfreau, B. D., Trent, J. O. and Chaires, J. B. (2007) Energetic basis of molecular recognition in a DNA aptamer. Biophysical Chemistry, 126: 165-175.
Wheelhouse, R. T., Jennings, S. A., Phillips, V. A., Pletas, D., Murphy, P. M., Garbett, N., Chaires, J. B., and Jenkins, T. C. (2006) Design, synthesis and evaluation of novel biarylpyrimidines - a new class of ligand for unusual nucleic acid structures. Journal of Medicinal Chemistry 49: 5187 - 5198.
Chaires, J. B. (2006) A thermodynamic signature for drug-DNA binding mode. Archives of Biochemistry and Biophysics 454: 24 - 29.
Antonacci, C., Chaires, J. B. and Sheardy, R. D. (2007) Biophysical characterization of the human telomeric (TTAGGG)4 repeat in a potassium solution. Biochemistry 46: 4654 - 4660.
Ragazzon, P., Garbett, N. and Chaires, J. B. (2007) Competition dialysis:
A method for the study of structural selective nucleic acid binding.
Methods 42: 173-182.