Professor

Email Dr. William Dean

Phone Number: 502-852-5227
Fax: 502-852-6222

Address: 319 Abraham Flexner Way, HSC-A, Room 601
Louisville, KY 40292  (40202 for express mail)

PhD, 1976, University of Michigan

Area of Interest:

Biochemistry of ion transporters; structure and function of membrane proteins

Dr. Dean is studying Ca2+ homeostasis in human platelets. He and his coworkers have established that the platelet plasma membrane calcium pump is inhibited in hypertension leading to increased cytosolic calcium and platelet hyperactivity, thus explaining the link between hypertension and thrombotic events such as heart attack and stroke. In addition, the role of platelet microparticles, membrane fragments released from activated platelets, in vascular disease and cancer is being studied using proteomic and lipidomic approaches.

Selected Publications

Tyagi, N., Roberts, A.M., Dean, W.L., Tyagi, S.C. and Lominadze, D.  (2008)  Fibrinogen induces endothelial cell permeability. Mol. Cell. Biochem. 307, 13-22.

Clem, B., Telang, S., Clem, A., Yalcin, A., Meier, J., Simmons, A., Rasku, M.A., Arumugam, S., Dean, W.L., Eaton, J., Lane, A., Trent, J.O., and Chesney, J. (2008) Small molecule inhibition of 6-pkhosphofructo-2-kinase activity suppresses glycolytic flux and tumor growth. Mol. Cancer Ther. 7, 110-120

Essick, E.E., Sithu, S. D., Dean, W.L., and D’Souza, S. (2008)  Pervanadate-induced shedding of the intercellular adhesion molecule (ICAM)-1 ectodomain is mediated by membrane type-1 matrix metalloproteinase (MT1-MMP). Mol. Cell. Biochem. 314: 151-159.

Patibandla, P.K., Sen, U., Tyagi, N., Dean, W.L., Tyagi, S.C., Roberts, A.M. and Lominadze, D. (2009) Fibrinogen induces alterations of endothelial cell tight junction proteins. J. Cell Physiol., in press.

Bozulic, L.D., Malik, M.T., Powell, D.W., Nanez, A., Link, A.J., , Ramos, K.S. and Dean, W.L. (2007) Plasma membrane Ca2+-ATPase associates with the actin cytoskeleton via CLP36 in human platelets. Thromb. Haemostas. 87, 587-97

Brown, C. S. and Dean, W.L. (2007) Regulation of plasma membrane Ca2+-ATPase in human platelets by calpain. Platelets 18, 207-211.

Bozulic, L.D., Malik, M.T. and Dean, W.LO. (2007) Effects of plasma membrane Ca2+-ATPase tyrosine phosphorylation on human platelet function. J. Thromb. Haemos. 5, 1041-1046.

Tang, D., Dean, W.L., Borchman, D. and Paterson , C.A. (2006) The influence of membrane lipid structure on plasma membrane Ca2+-ATPAse activity. Cell Calcium 39, 209-216.

Bozulic, L.D., Dean, W.L. and Delamere, N.A. (2005) The Influence of Src-Family Tyrosine Kinases on Na,K-ATPase Activity in Lens Epithelium. Invest. Ophthalmol. Vis. Sci. 46, 618-622

Khundmiri, S.J., Dean, W.L., McLeish, K.R., and Lederer, E.D. (2005) PTH-mediated Regulation of Na,K-ATPase requires ERK-dependent translocation of PKC alpha. J. Biol. Chem. 280, 8705-13.