Professor

Email Dr.Kenneth Ramos
Phone Number: 502-852-7340
Fax: 502-852-3659

Address: Baxter Biomedical Research Bldg, Suite 221
Louisville, KY 40202

Ph.D., 1983 University of Texas
M.D., 2011 University of Louisville

Area of Interest:

Investigators:
Diego E. Montoya-Durango
Vilius Stribinskis

Dr. Ramos is a leading expert in the study of molecular mechanisms of environmental injury and genetic and epigenetic determinants of environmental disease. A major thrust in his laboratory is the study of mammalian retroelements and endogenous retroviral-like sequences.

Selected Recent Publications:

Montoya, D.E. and Ramos, K.S. L1 retrotransposon and retinoblastoma: Molecular linkages between epigenetics and cancer. Current Molecular Medicine, in press, 2010.

Rouchka, E., Montoya, D., Stribinskis,V., Ramos, K. and Kalbfleisch, T. Assessment of genetic variation for the LINE1 retrotransposon from next generation sequence data. BMC Bioinformatics, in press, 2010.

Ramos, K.S. and Nanez, A. Genetic regulatory networks of nephrogenesis: deregulation of WT1 splicing by benzo(a)pyrene. Embryo Today 87:192-197, 2009.

Ramos, K.S. H-ras controls phenotypic profiles of vascular smooth muscle cells and the pathogenesis of vascular proliferative disorders. Circulation Research 104, 1139-1141, 2009.

Ramos, K.S. Unraveling genetic regulatory networks of mammalian retroelements. BMC Proceedings 3, 1-3, 2009.

Montoya-Durango, D.E, Liu, Y. and Ramos, K.S. Epigenetic control of mammalian LINE-1 retrotransposon by retinoblastoma proteins. Mutation Research 665, 20-28, 2009.

Lu, Z., Mofang, L., Stribinskis, V., Kling, C.M., Ramos, K.S., Colburn, N.H. and Yong, Li. MicroRNA-21 Promotes Cell Transformation by Targeting the Programmed Cell Death 4 Gene. Oncogene 27, 4373-4379, 2008.

Partridge, C.R, He, Qiang and Ramos, K.S. Genetic networks of cooperative redox regulation of osteopontin. Matrix Biology 27, 462-474, 2008

Ramos, K.S., Partridge, C.R. and Teneng, I. Genetic and molecular mechanisms of chemical atherogenesis. Mutation Research 621, 18-30, 2007.

Teneng, I, Stribinskis, V and Ramos, K.S. Context specific regulation of LINE-1. Genes Cells 12, 1101-1110, 2007.

Rempala, G. Ramos, K.S., Kalbfleisch, T and Teneng, I. Validation of a mathematical model of gene transcription in aggregated cellular systems. Application to L1 retrotransposition. Journal of Computational Biology 3, 339-349, 2007.

Tadesse, M., Johnson, C.D., Qiang, H, Carroll, R. and Ramos, K.S. Comparison of high-density short oligonucleotide microarray platforms. Current Bioinformatics 2, 203-213, 2007.

Ramos, K.S., He, Q, Kalbfleisch, T, Stribinskis, V and Brun, M. Computational and biological inference of gene regulatory networks of LINE-1 retrotransposon. Genomics 90, 176-185, 2007.

Ramos, K.S., Steffen, M.C., Falahatpisheh, M.H. and Nanez, A. From genomics to mechanistic insight: A global perspective on molecular deficits induced by environmental agents. Environmental and Molecular Mutagenesis 48, 395-399, 2007.

Stribinskis, V. and Ramos, K.S. Rpm2p, a protein subunit of mitochondrial RNase P, localizes to cytoplasmic processing (P) bodies and interacts with Dcp2p, DHH1 and PAB1. Nucleic Acids Research 35, 1301-1311, 2007.

Johnson, C.D., Balagurunathan, Y., Tadesse, M., Falahatpisheh, M.H., Brun, M., Walker, M., Dougherty, E.R. and Ramos, K.S. Unraveling gene-gene interactions regulated by ligands of the aryl hydrocarbon receptor. EHP:Toxicogenomics 112, 403-412, 2004.

Jones, S. A., Patterson, J.L., Ramos, K.S. and Wilson, E. Modulation of ERK1.2 and cell cycle regulatory proteins in oxidatively stressed vascular smooth muscle cells. Journal of Cellular Biochemistry 91, 1248-1259, 2004.

Weber, T.J., Negash, S., Smallwood, H.S., Ramos, K.S., Thrall, B.D. and Squier, T.C. Calmodulin involvement in stress-activated nuclear localization of albumin in JB6 epithelial cells. Biochemistry 2004 Jun 15;43(23):7443-502004.

Falahatpisheh, H. M. and Ramos, K.S. Ligand activated Ahr signaling leads to disruption of nephrogenesis and altered Wilms’ tumor suppressor gene splicing. Oncogene 14, 2160-2171, 2003.

Johnson, C.D., Tadesse, M., Falahatpisheh, M.H., Balagurunathan, Y., Lu, K.P., Carroll, R.J., Dougherty, E.R., Afshari, C.A. & Ramos, K.S. (2003) Genomic profiles and predictive biological networks in oxidant-induced atherogenesis. Physiological Genomics 13, 263-275

Lu, K.P. and Ramos, K.S. Redox activation of a novel A-type mouse L1Md retrotransposon in vascular smooth muscle cells. Journal of Biological Chemistry 278, 28201-28209, 2003.

Kondraganti SR, Fernandez-Saluguero P, Gonzalez FJ, Ramos KS, Jiang W, Moorthy B. Polycyclic aromatic hydrocarbon-inducible DNA adducts: evidence by 32P-postlabeling and use of knockout mice for Ah receptor-independent mechanisms of metabolic activation in vivo. Int J Cancer. 2003 Jan 1;103(1):5-11.

Holderman MT, Miller KP, Dangott LJ, Ramos KS. Identification of albumin precursor protein, Phi AP3, and alpha-smooth muscle actin as novel components of redox sensing machinery in vascular smooth muscle cells. Mol Pharmacol. 2002 May;61(5):1174-83.

Moorthy B, Miller KP, Jiang W, Ramos KS. The atherogen 3-methylcholanthrene induces multiple DNA adducts in mouse aortic smooth muscle cells: role of cytochrome P4501B1. Cardiovasc Res. 2002 Mar;53(4):1002-9.

Parrish AR, Alejandro NF, Bral CM, Kevin Kerzee J, Bowes RC, Ramos KS. Characterization of glomerular cell phenotypes following repeated cycles of benzo[a]pyrene injury in vitro. Biochem Pharmacol. 2002 Jul 1;64(1):31-9.

Wilson E, Parrish AR, Bral CM, Williams ES, Ramos KS. Collagen suppresses the proliferative phenotype of allylamine-injured vascular smooth muscle cells. Atherosclerosis. 2002 Jun;162(2):289-97.

Holderman MT, Miller KP, Dangott LJ, Ramos KS. Identification of albumin precursor protein, Phi AP3, and alpha-smooth muscle actin as novel components of redox sensing machinery in vascular smooth muscle cells. Mol Pharmacol. 2002 May;61(5):1174-83.

Moorthy B, Miller KP, Jiang W, Ramos KS. The atherogen 3-methylcholanthrene induces multiple DNA adducts in mouse aortic smooth muscle cells: role of cytochrome P4501B1. Cardiovasc Res. 2002 Mar;53(4):1002-9.

Lu KP, Alejandro NF, Taylor KM, Joyce MM, Spencer TE, Ramos KS. Differential expression of ribosomal L31, Zis, gas-5 and mitochondrial mRNAs following oxidant induction of proliferative vascular smooth muscle cell phenotypes. Atherosclerosis. 2002 Feb;160(2):273-80.

Kerzee JK, Ramos KS. Constitutive and inducible expression of Cyp1a1 and Cyp1b1 in vascular smooth muscle cells: role of the Ahr bHLH/PAS transcription factor. Circ Res. 2001 Sep 28;89(7):573-82.

Fan YY, Ramos KS, Chapkin RS. Dietary gamma-linolenic acid suppresses aortic smooth muscle cell proliferation and modifies atherosclerotic lesions in apolipoprotein E knockout mice. J Nutr. 2001 Jun;131(6):1675-81.

Falahatpisheh MH, Donnelly KC, Ramos KS. Antagonistic interactions among nephrotoxic polycyclic aromatic hydrocarbons.J Toxicol Environ Health A. 2001 Apr 6;62(7):543-60.