Department of Biochemistry and Molecular Biology

Preston Pope Joyes Professor

Email Dr. Nancy Martin
Phone Number: 502-852-5226
Fax: 502-852-6222

Address: Delia Baxter Building (Baxter II) 102C
Louisville, KY 40202

PhD, 1975, Harvard University

Area of Interest:

Mitochondrial biosynthesis and protein targeting

Dr. Martin is currently serving as the Senior Vice President for Research and she has suspended her research program.

Selected Publications:

Stribinskis, V., Heyman, H.C., Ellis, S.R., Steffen, M. C. and Martin, N.C (2005). Rpm2p, a component of yeast mitochondrial RNase P, acts as a transcriptional activator in the nucleus. Mol. Cell. Biol. 25, 6546-58.

Seif ER, Forget L, Martin NC, Lang BF. Mitochondrial RNase P RNAs in ascomycete fungi: lineage-specific variations in RNA secondary structure. RNA. 2003 Sep;9(9):1073-83.

Martin NC. Location alters tRNA identity: Trypanosoma brucei's cytosolic elongator tRNAMet is both the initiator and elongator in mitochondria. Proc Natl Acad Sci U S A. 2002 Feb 5;99(3):1110-2.

Stribinskis V, Gao GJ, Sulo P, Ellis SR, Martin NC. Rpm2p: separate domains promote tRNA and Rpm1r maturation in Saccharomyces cerevisiae mitochondria. Nucleic Acids Res. 2001 Sep 1;29(17):3631-7.

Pluta K, Lefebvre O, Martin NC, Smagowicz WJ, Stanford DR, Ellis SR, Hopper AK, Sentenac A, Boguta M. Free Full Text Maf1p, a negative effector of RNA polymerase III in Saccharomyces cerevisiae. Mol Cell Biol. 2001 Aug;21(15):5031-40.

Stribinskis V, Gao GJ, Ellis SR, Martin NC. Rpm2, the protein subunit of mitochondrial RNase P in Saccharomyces cerevisiae, also has a role in the translation of mitochondrially encoded subunits of cytochrome c oxidase. Genetics. 2001 Jun;158(2):573-85.

Gajewska B, Kaminska J, Jesionowska A, Martin NC, Hopper AK, Zoladek T. WW domains of Rsp5p define different functions: determination of roles in fluid phase and uracil permease endocytosis in Saccharomyces cerevisiae. Genetics. 2001 Jan;157(1):91-101.

Williams LR, Ellis SR, Hopper AK, Davis EO, Martin NC. Splicing before import - an intein in a mitochondrially targeted preprotein folds and is catalytically active in the cytoplasm in vivo. FEBS Lett. 2000 Jul 7;476(3):301-5. PMID: 10913632; UI: 20374967

Lutz MS, Ellis SR, Martin NC. Proteasome mutants, pre4-2 and ump1-2, suppress the essential function but not the mitochondrial RNase P function of the Saccharomyces cerevisiae gene RPM2. Genetics. 2000 Mar;154(3):1013-23. PMID: 10757750; UI: 20221713

Benko AL, Vaduva G, Martin NC, Hopper AK. Competition between a sterol biosynthetic enzyme and tRNA modification in addition to changes in the protein synthesis machinery causes altered nonsense suppression. Proc Natl Acad Sci U S A. 2000 Jan 4;97(1):61-6. PMID: 10618371; UI: 20087202

Stanford DR, Martin NC, Hopper AK. ADEPTs: information necessary for subcellular distribution of eukaryotic sorting isozymes resides in domains missing from eubacterial and archaeal counterparts. Nucleic Acids Res. 2000 Jan 15;28(2):383-92. PMID: 10606634; UI: 20075125

Vaduva G, Martinez-Quiles N, Anton IM, Martin NC, Geha RS, Hopper AK, Ramesh N. The human ASP-interacting protein, WIP, activates the cell polarity pathway in yeast. J Biol Chem. 1999 Jun 11;274(24):17103-8. PMID: 10358064; UI: 99287912

Tolerico LH, Benko AL, Aris JP, Stanford DR, Martin NC, Hopper AK. Saccharomyces cerevisiae Mod5p-II contains sequences antagonistic for nuclear and cytosolic locations. Genetics. 1999 Jan;151(1):57-75. PMID: 9872948; UI: 99091547

Groom KR, Heyman HC, Steffen MC, Hawkins L, Martin NC. Kluyveromyces lactis SEF1 and its Saccharomyces cerevisiae homologue bypass the unknown essential function, but not the mitochondrial RNase P function, of the S. cerevisiae RPM2 gene. Yeast. 1998 Jan 15;14(1):77-87. PMID: 9483797; UI: 98144791

Martin NC, Lang BF. Mitochondrial RNase P: the RNA family grows. Nucleic Acids Symp Ser. 1997;(36):42-4. PMID: 9478201; UI: 98138688

Stribinskis, V., G.-J. Gal, P. Sulo, Y.-L. Dang and N.C. Martin (1996) Yeast mitochondrial RNase RNA synthesis is altered in an RNase P protein subunit mutant: insights into the biogenesis of a mitochondrial RNP. Mol Cell Biol 16, 3429-3436.

Wolfe CL, Hopper AK, Martin NC (1996) Mechanisms leading to and the consequeces of altering the normal distribution of ATP(CTP):tRNA nucleotidyltransferase in yeast. J Biol Chem 271, 4679-4686.