Qiutang Li, Ph.D.

Education:Qiutang Li, Ph.D. 

B.S., Peking University, Beijing, China; 1987
M.S., Peking University, Beijing, China; 1990
Ph.D., Washington University, St. Louis, MO; 1997

Curriculum Vitae

Current Positions:

Professor, Department of Ophthalmology and Visual Sciences
Associate faculty, Department of Biochemistry and Molecular Biology
Associate Member, James Graham Brown Cancer Center

Contact Information:

Kentucky Lions Eye Center, Room 215
University of Louisville School of Medicine
301 East Muhammad Ali Boulevard
Louisville, KY40202
502-852-2409 (phone)
502-852-6909 (fax)

Research Description:

My laboratory has been interested in addressing biological and clinical questions using mouse models of human eye diseases.

1)    Role of Hippo/Yap1 in the eye.  Our recent effort has been focused on the function of the Hippo/Yap1 pathway in eye. Hippo signaling pathway is an evolutionarily conserved pathway that regulates stem/progenitor cell proliferation, fate determination, or apoptosis during development and malignant cell growth in carcinomas. Although the importance of YAP1 to eye has been recently illustrated, the underlying mechanisms are not very clear. We are currently studying the YAP1 function and its regulatory mechanisms in different cell types in the eye using conditional knockout mice.

2)    IKK2/NF-kB inhibition of angiogenesis.  We aim to elucidate the molecular and cellular mechanisms underlying IKK2/NF-kB inhibition of neovascularization. We have recently discovered that inhibition of the IKK2/NF-kB pathway can significantly attenuate laser-induced choroidal neovascularization (NV), and injury-induced corneal NV; and proposed that this pathway can serve as a rational targeting candidate for development of novel alternative therapeutics. Understanding the link between IKK2/NF-kB and NV may present broad clinical implications for many NV-related diseases, including AMD, diabetic retinopathy and tumor formation.

Literature Cited:

Study of the NF-kB signal transduction pathways

  1. Li Q, Van Antwerp D, Mercurio F, Lee KF, Verma IM.  Severe liver degeneration in mice lacking the IkappaB kinase 2 gene.  Science 1999 Apr 9;284(5412):321-5. PMID: 10195897. [ http://science.sciencemag.org/content/284/5412/321.long ]
  2. Li Q, Estepa G, Memet S, Israel A, Verma IM.  Complete lack of NF-kB activity in IKK1 and IKK2 double deficient mice: Additional defect in neurulation.  Genes & Development 2000 Jul 15;14(14):1729-33. PMID: 10898787. PMCID: PMC316792.
  3. Li Q, Verma IM.  NF-kappaB regulation in the immune system.  Nature Reviews Immunology 2002 Oct;2(10):725-34. PMID: 12360211.
  4. Li Q, Lu Q, Bottero V, Estepa G, Morrison L, Mercurio F, Verma IM.  Enhanced NF-kB activation and cellular function in macrophages lacking IkB kinase 1 (IKK1).  Proceedings of the National Academy of Sciences USA 2005 Aug 30;102(35):12425-30. PMID: 16116086. PMCID: PMC1194954.

Study of epidermal epithelial biology

  1. Li Q, Lu Q, Hwang JY, Buscher D, Lee KF, Izpisua-Belmonte JC, Verma IM.  IKK1-deficient mice exhibit abnormal development of skin and skeleton.  Genes & Development 1999 May 15;13(10):1322-8. PMID: 10346820. PMCID: PMC316728.
  2. Li Q, Lu Q, Estepa G, Verma IM.  Identification of 14-3-3 sigma mutation causing cutaneous abnormality in repeated epilation mutant mouse.  Proceedings of the National Academy of Sciences USA 2005 Nov 1;102(44):15977-82. PMID: 16239341. PMCID: PMC1276109.
  3. Xin Y, Lu Q, Li Q.  14-3-3σ is required for club hair retention.  Journal of Investigative Dermatology 2010 Jul;130(7):1934-6. PMID: 20237493. [ https://www.sciencedirect.com/science/article/pii/S0022202X15348892?via%3Dihub ]
  4. Xin Y, Lu Q, Li Q.  IKK1 control of epidermal differentiation is modulated by Notch signaling.  American Journal of Pathology 2011 Apr;178(4):1568-77. PMID: 21435444. PMCID: PMC3078471.

Study the cornea epithelium homeostasis

  1. Xin Y, Lu Q, Li Q.  14-3-3sigma controls corneal epithelial cell proliferation and differentiation through the Notch signaling pathway.  Biochemical & Biophysical Research Communications  2010 Feb 19;392(4):593-8. PMID: 20100467.  PMCID: PMC2828677.
  2. Lu Q, Xin Y, Ye F, Foulks G, Li Q.  14-3-3σ controls corneal epithelium homeostasis and wound healing.  Investigative Ophthalmology & Visual Science 2011 Apr 14;52(5):2389-96. PMID: 21228373. PMCID: PMC3081250.
  3. Lu H, Lu Q, Zheng Y, Li Q.  Notch signaling promotes the corneal epithelium wound healing.  Molecular Vision 2012;18:403-411. PMID: 22355251. PMCID: PMC3283215.
  4. Kasetti RB, Gaddipati S, Tian S, Xue L, Kao WW, Lu Q, Li Q.  Study of corneal epithelial progenitor origin and the Yap1 requirement using keratin 12 lineage tracing transgenic mice.  Science Reports 2016 Oct 13;6:35202. doi: 10.1038/srep35202. PMID:27734924. PMCID: PMC5062132.

Understanding the NF-kB pathway in neovascularization

  1. Lu  H, Lu Q, Gaddipati S, Kasetti RB, Wang W, Pasparakis M, Kaplan HJ,Li Q..  IKK2 inhibition attenuates laser-induced choroidal neovascularization.  PLoS One 2014 Jan 28;9(1):e87530. PMID: 24489934. PMCID: PMC3905033.
  2. Gaddipati S, Lu Q, Kasetti RB;Miller MC, Trent JO, Kaplan HJ,Li Q.  IKK2 inhibition using TPCA-1/PLGA microparticles attenuates laser-induced choroidal neovascularization and macrophage recruitment.  PLoS One 2015 Mar 24;10(3):e0121185. PMID:25803615. PMCID: PMC4372421.
  3. Dong L, Nian H, Shao Y, Zhang Y, Li Q, Yi Y, Tian F, Li W, Zhang H, Zhang X, Wang F, Li X.  PTB-associated splicing factor inhibits IGF-1-induced VEGF upregulation in a mouse model of oxygen-induced retinopathy.  Cell & Tissue Research 2015 May;360(2):233-43. PMID: 25638408.

Understanding the Hippo/YAP1 function in vivo

  1. Liu Y, Ye F, Li Q, Tamiya S, Darling DS, Kaplan HJ, Dean DC.  Zeb1 represses Mitf and regulates pigment synthesis, cell proliferation, and epithelial morphology.  Investigative Ophthalmology & Visual Science 2009 Nov;50(11):5080-8. PMID: 19515996. PMCID: PMC3648851.
  2. Ma X, Chen Y, Xu W, Wu N, Li M, Cao Y, Wu S, Li Q, Xue L.  Impaired Hippo signaling promotes Rho1-JNK-dependent growth.  Proceedings of the National Academy of Sciences USA 2015 Jan 27;112(4):1065-70. PMID: 25583514. PMCID: PMC4313816.
  3. Sambandam SAT, Kasetti RB, Xue L, Dean DC, Lu Q, Li Q.  14-3-3sigma regulates keratinocyte proliferation and differentiation by modulating Yap1 cellular localization.  Journal of Investigative Dermatology 2015 Jun 6;135(6):1621-8. PMID: 25668240. PMCID: PMC4430425.
  4. Kasetti RB, Gaddipati S, Tian S, Xue L, Kao WW, Lu Q, Li Q.  Study of corneal epithelia progenitor origin and the Yap1 requirement of using keratin 12 lineage tracing transgenic mice.   Science Reports 2016 Oct 13;6:35202. doi: 10.1038/srep35202. PMID: 27734924. PMCID: PMC5062132.

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