Douglas M. Coldwell, PhD, MD


PhD, Materials Science, Rice University, 1975
MD, University of Texas Medical Branch, 1980
Residency, Diagnostic Radiology, Pennsylvania State University, 1983
Fellowship, Interventional Radiology, University of Texas System Cancer Center, MD Anderson Hospital, 1984
Board Certified, American Board of Radiology, 1986
Certificate of Added Qualifications in Vascular and Interventional Radiology, ABR, 1995

Curriculum Vitae

Current Positions:

Professor of Radiology and Bioengineering, University of Louisville
Director, Vascular and Interventional Radiology and Interventional Oncology

Clinical Focus and Research:

My focus for the last 30 years has been the treatment of inoperable tumors with cutting edge technology that can treat the tumor and spare normal tissue with the idea that the patient’s quality of life and their survival is improved.  I was the first in the United States to treat tumors in the liver with tiny particles that are delivered through the arteries to deliver a high dose of radiation to the tumor while sparing normal tissues usually in the liver.  Additionally, I treat bone metastases, and tumors that can be safely reached by probes that deliver heat and “cook” the tumor, and those tumors whose blood supply can be isolated from normal tissues so that specific chemotherapy or radiation can be delivered.  I am also interested in head and neck cancers in preventing the complications of the tumor eroding into the carotid artery. These techniques insure that my patients receive the most effective therapy that can directly be applied to the tumor.

The research I am interested in includes the mathematical description of blood vessels so that diagnostic tests can be more accurate,  the simulation of blood flow to the liver to determine the effects of treatments to the liver, and in some novel therapies that are based on specific targets in the tumor gene.  I also conduct industry-sponsored trials and National Cancer Institute-funded cooperative group trials.

Literature Cited:

  1. Jenkins J, Brook A, Georgy B, Coldwell D, et al. Treatment of Spine Metastatic Lesions with a Navigational Bipolar Radiofrequency Ablation Device: A multi-center retrospective study. Pain Physician (to appear).
  2. Vyleta M, Coldwell D.  Radioembolization in the treatment of neuroendocrine tumor metastases to the liver.  Int J of Hepatology, vol. 2011, Article ID 785315, 5 pages, 2011. doi:10.4061/2011/785315.
  3. Coldwell D, Sangro B, Salem R, Wasan H, Kennedy.  Radioembolization in the treatment of unresectable liver tumors:  experience across a range of primary cancers.  Am J Clin Oncol 2010 Nov 30. [Epub ahead of print]
  4. Coldwell D, Sangro B, Wasan H, Salem, Kennedy A.  General selection criteria of patients for radioembolzation of liver tumors:  An international working group report.  Am J Clin Oncol 2011 Jun;34(3):337-41.
  5. Shi H, Hite M, Palmer G, Coldwell D.  Quantitative analysis of tumor vasculature in hepatocellular carcinoma.  Society of Interventional Radiologists Annual Meeting, 2013.

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