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Optimal Aging Institute receives MediStar award

Optimal Aging Institute receives MediStar award

Anna Faul accepts Medistar award

Selected for its excellence in creating innovative methods to reduce health care costs and improve quality of life for older adults, the Institute for Sustainable Health & Optimal Aging at the University of Louisville recently received the MediStar’s Bluegrass Care Navigators Aging Care Award.  

During a ceremony held October 30 at the Muhammad Ali Center, the institute was lauded for its Flourish Program, an innovative, evidence-based approach to health care grounded in the concepts of social determinants of health and integrated care coordination 

The program is based on the institute’s Flourish Care Coordination Model, which links clinical and behavioral health care plans with a community care plan. Patients in the program receive detailed assessments, weekly and monthly monitoring, interdisciplinary health care consultation and care planning, coordination of care, community resource planning and support, as well as behavioral and mental health support. 

In addition to improving health outcomes, the Flourish model hopes to reduce health care costs by leveraging new rules through Medicare Advantage that will pay for non-skilled in-home service providers beginning in 2019.

The institute was one of seven award winners. UofL School of Public Health and Information Sciences faculty member, Sarah Moyer, M.D., also was honored for her work as a co-chair of the Louisville Health Advisory Board. She is director of the Louisville Metro Department of Public Health and Wellness.

 

UofL ophthalmology residents certified earlier in training for advanced laser eye surgery

UofL residents earn certification usually achieved later in training thanks to public-private partnership
UofL ophthalmology residents certified earlier in training for advanced laser eye surgery

Residents Sidharth Puri, M.D., and Mohammad Ali Sadiq M.D.

Ophthalmology residents are learning to perform advanced eye surgeries earlier in their training at the University of Louisville thanks to a unique partnership with Suburban Excimer Laser Center and training on laser equipment from J&J Vision, a division of Johnson & Johnson.

“This is a novel public-private venture that provides a unique opportunity to combine the resources of a Fortune 500 company, the UofL ophthalmology program and a private laser center staffed with highly experienced clinicians,” said Richard Eiferman, M.D., clinical professor of ophthalmology with the University of Louisville School of Medicine, who oversees the training.  

The UofL Department of Ophthalmology & Visual Sciences is one of only three programs in the United States in which the residents are trained for LASIK and PRK procedures during residency. The physicians in the laser center train the residents in performing the procedures, while representatives of Johnson & Johnson instruct them in the use of J&J Vision Surgical equipment for these procedures.

The program’s success promptly led to expanding it to include ophthalmology residents from the University of Kentucky Department of Ophthalmology and Visual Sciences as well. Eight residents from UofL and six residents from UK are participating in the elective program.

The final stage of the training takes place at Suburban Excimer Laser Center, in which the residents perform surgeries under the direction of Eiferman, a clinical professor in the UofL School of Medicine, Frank Burns, M.D., and Mark Cassol, M.D., a lecturer in the UofL School of Medicine.

Earlier this year, two senior residents from UofL were the first medical residents in the United States to complete all of the required training and become FDA certified to perform the laser surgery prior to completing their three-year residency program. The certification typically is achieved by physicians engaged in specialized cornea fellowships following ophthalmology residency.

Only two other eye programs in the United States, Wills Eye Hospital in Philadelphia and the University of Miami’s Bascom Palmer Eye Institute, have similar programs.

Sidharth Puri, M.D., chief ophthalmology resident at UofL, said access to this training gives UofL residency graduates a significant advantage.

“This is a big strength for our program. It gives residents top notch exposure to the newest surgical techniques available,” Puri said.

To assist these residents in their training, the program is offering more affordable eye surgery to UofL faculty, staff, students and alumni. Resident procedures, staffed by Richard Eiferman, M.D., Frank Burns, M.D., and Mark Cassol, M.D., range from $495-$795 per eye for custom LASIK. For an appointment, call 502-588-0550.

 

November 1, 2018

A special Halloween treat for NICU families

A special Halloween treat for NICU families

Family delivers Halloween baskets to NICU

Last year, Jaclyn Maria and her husband were leaving University of Louisville Hospital with a brand new bundle of life, Luca. Taking home their baby boy the day before Halloween was a special time for the family, after a challenging journey awaiting his arrival.

Jaclyn had been on bed rest at the hospital for 10 weeks after going into labor at 22 weeks. She delivered Luca on Oct. 1, 2017, at 32 weeks, and he stayed in the NICU for a month.

Jaclyn says she had a unique experience at the Center for Women and Infants at UofL Hospital. She worked with a music therapist to write songs for her baby and visited with a therapy dog to ease her anxiety.

“I had a daily a routine, and the weeks passed quickly,” she said.

“The staff did so much to spoil us and make the season of Halloween with our son special despite being in the NICU,” Jacyln said. “Thanks to the staff, we have fond memories of what could have been a very difficult time for our family.”

She received a Halloween card with Luca’s footprint, and a group of volunteers who knit costumes for the NICU babies made him a sock monkey outfit with his name and birthdate.

“It was a gift you don’t expect that means so much, and we treasure that,” she said.

As a way to pay it forward, Jaclyn launched a fund-raiser this year to fill enough Halloween baskets for every family in the NICU. Filled with candy and care items like tissues and lotion, she delivered the baskets in time to make it a special Halloween for those in a similar circumstance.

“We can’t believe it has been a year – they did so much for us while we were here and we are glad to bring cheer to others,” Jaclyn said.

American Heart Association, universities awarded $17.98 million to continue research to provide evidence for tobacco regulation

UofL, other universities, to conduct research studies for the next five years

Building upon the success of the past five years, the American Heart Association (AHA), the world’s leading voluntary health organization devoted to building longer, healthier lives, in partnership with the University of Louisville, has received a nearly $18 million, five-year renewal grant from the National Institutes of Health (NIH), funded by the Food and Drug Administration (FDA)’s Center for Tobacco Products to continue support for the American Heart Association Tobacco Regulation and Addiction Center.

Under the direction of Rose Marie Robertson, M.D., the association’s deputy chief science and medical officer, and Aruni Bhatnagar, Ph.D., the Smith and Lucille Gibson Chair in Medicine at UofL, the Center examines the short- and long-term cardiovascular effects of tobacco products and the overall toxicity of tobacco products and their constituents.

The AHA Tobacco Regulation and Addiction Center received $20 million in its initial funding in 2013 through this same interagency partnership between the National Institutes of Health and the Food and Drug Administration as the FDA’s Center for Tobacco Products began its investment in the Tobacco Centers of Regulatory Science (TCORS). The AHA Center is a multi-institutional network focused on creating a broad scientific base to inform the FDA’s regulation of tobacco product manufacturing, distribution and marketing.

The renewal grant awards were based on the scientific and technical merit of the applicant organizations. The AHA Tobacco Regulation and Addiction Center’s quality of research and productivity in its first five years created a strong foundation for future research and led to the renewed funding.

“We are honored to continue to be a part of this important national movement to protect the public health from the tragic consequences of tobacco product use that takes the lives of more than 480,000 Americans each year,” Robertson said. “In light of the fast-paced shifts in the landscape of new tobacco products, an accelerating trend of the use of these products by our nation’s children and an emerging generation of dual or poly-tobacco product users, the need for a better understanding of the health effects of these novel products has become even more imperative.”

During the past five years, more than 50 investigators from 12 institutions throughout the nation have collaborated on 82 publications from the center that examined topics such as the reasons behind the growing prevalence of adults and young adults who are vaping, the toxicity of flavoring chemicals used in e-cigarettes and the preliminary indicators of the growing use of poly-use, or the practice of using multiple tobacco products at the same time.

To date, researchers have found the use of tobacco products such as traditional cigarettes, hookahs, smokeless tobacco, electronic cigarettes and e-hookahs leads to a decrease in immune cells and prevents repair of damaged endothelial cells, increasing the risk of contracting secondary infections. Additionally, use of electronic hookahs can increase the risk of blood clots.

“Dr. Bhatnagar and his colleagues continue to demonstrate their leadership in the field of environmental cardiology, which obviously includes the use of tobacco,” said UofL President Neeli Bendapudi, Ph.D. “This renewal demonstrates the significance of the research being conducted and the potential impact it has on anyone who uses tobacco or similar products.  

“Hopefully it will impact those who are considering using tobacco both by providing information regarding health effects that can be used in health risk warnings, and also by providing FDA data regarding the toxicity of individual constituents within tobacco-derived aerosols.”

Research at the nine institutions –Boston University, Johns Hopkins University,  New York University, University of Louisville, University of Mississippi Medical Center, Wake Forest University, Stanford University, University of Iowa and National Jewish Hospital – participating in the AHA Center over the next five years will focus on understanding the toxic potential of combustible and newer forms of tobacco products, identifying the biological markers of cardiovascular injury caused by components of tobacco products and assessing the risk of heart disease for different racial and ethnic groups of people from the use of newer tobacco products.

“Identifying the biomarkers of cardiovascular injury caused by tobacco use can lead to improved standards for testing of novel tobacco products and lead to policies regulating the level of harmful chemicals present in tobacco products, thus aiming to reduce the overall burden of cardiovascular injury in the general population,” Bhatnagar said.

The researchers hope to identify specific substances from tobacco products and in their smoke or aerosols that contribute to heart disease. This includes flavoring chemicals used in electronic nicotine delivery systems such as  e-cigarettes, e-hookahs, JUUL and others, along with chemical solvents used in such products.

The center also has responsibility for training the next generation of tobacco regulatory scientists who will continue research into tobacco and its health effects. To this end, 23 people have been trained as fellows in tobacco regulatory science and 11 fellowship projects have been funded over the first 5 years. The center has also funded 12 short-term projects to study emerging topics of interest to tobacco regulation.

The renewed center has been designed to retain this flexibility to respond to FDA’s research needs in a shifting landscape of tobacco use through rapid-response research funding and independent fellowship grants that can enhance the center’s research database alongside its flagship projects.

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The American Heart Association is a leading force for a world of longer, healthier lives. With nearly a century of lifesaving work, the Dallas-based association is dedicated to ensuring equitable health for all. We are a trustworthy source empowering people to improve their heart health, brain health and well-being. We collaborate with numerous organizations and millions of volunteers to fund innovative research, advocate for stronger public health policies, and share lifesaving resources and information. Connect with us on heart.org, Facebook, Twitter or by calling 1-800-AHA-USA1.

 

 

Global satellite mini-conference on air pollution and health scheduled for Oct. 30-31 at University Club

UofL Christina Lee Brown Envirome Institute provides free access to World Health Organization event
Global satellite mini-conference on air pollution and health scheduled for Oct. 30-31 at University Club

Air pollution from coal-fired power plants such as the Mill Creek Plant in Louisville can have a significant impact on health. (Photo: The Nature Conservancy)

The Christina Lee Brown Envirome Institute and its Center for Healthy Air, Water and Soil at the University of Louisville will host a satellite mini-conference of the World Health Organization’s Global Conference on Air Pollution and Health on Tuesday and Wednesday, Oct. 30-31. The conference will be held from 10 a.m. to 1 p.m. each day at the University Club, 200 E. Brandeis Ave.

“We are pleased to be an official satellite mini-conference host site of the World Health Organization’s first global conference on air pollution and health,” said Ted Smith, Ph.D., Center for Healthy Air, Water and Soil Director. “This conference is a prime opportunity for Kentuckiana citizens who are interested in the impact air pollution has on health and well-being to share ideas and learn from experts around the globe as well as those in our own community.”

The mini conference will include video streams from the plenary session of the main conference in Geneva with an opportunity for discussions in Louisville to be shared with the main conference each day.

Tuesday’s session will open with remarks from Smith. A session will follow that examines the scientific evidence that exists showing the impact air pollution has on health with a discussion to follow mediated by Daniel Conklin, Ph.D., UofL professor of medicine.

Wednesday’s session will cover engaging the health sector as a leader of change in public policy, and communication, advocacy and partnerships to develop opportunities and remove barriers for promoting clean air policy.

Admission is free but reservations are required to receive a box lunch. To register, go to the online registration form here. For additional information, contact Lauren Anderson at lauren.anderson@louisville.edu.

The event is organized in collaboration with the United National Environment Programme, World Meteorological Organization, Climate and Clean Air Coalition, the secretariat of the UN Framework Convention on Climate Change, UN Economic Commission for Europe and The World Bank.

Increasing access to psych therapies is focus of UofL lecture

Talk kicks off Depression Center’s 12th annual conference
Increasing access to psych therapies is focus of UofL lecture

David M. Clark, Ph.D.

The need to make psychological therapies widely available is the focus of the “Building Hope” public lecture on Thursday, Nov. 1.

David M. Clark, Ph.D., professor of experimental psychology at the University of Oxford in England and director of the Oxford Centre of Anxiety Disorders & Trauma, will present “Thrive: How Psychological Therapies Transform Lives and Save Money.” The event is part of the “Building Hope” public lecture series sponsored by the University of Louisville Depression Center and will be held at 6 p.m. at the Clifton Center, 2117 Payne St.

“Effective psychological treatments are available for most mental health problems, but the public rarely benefits. This can be changed,” Clark said. “The clinical and economic arguments for increasing access to psychological therapies are overwhelming.”

The lecture kicks off the Depression Center’s 12th annual conference at the Clifton Center on Friday, Nov. 2, that will focus on translating science into clinical practice for depression and anxiety disorders.

Conference sessions are geared toward psychiatrists, psychologists, social workers, nurse practitioners, primary care physicians and other mental health clinicians. Focusing on some of the most promising developments in biological psychiatry and psychotherapy, participants will learn about advanced methods for challenging clinical problems.

Keynote speakers include Clark, Mark A. Frye, M.D., professor and chair of the Department of Psychiatry and Psychology at the Mayo Clinic and director of the Mayo Clinic Depression Center, and Laura Wright McCray, M.D., associate professor and residency program director of the Department of Family Medicine at the University of Vermont.

Continuing education credits are available for attendees.

Attendance is free for UofL physicians, nurses, faculty members, students, residents and fellows. Registration for other health care professionals costs $100. For more information, call 502-588-4886 or visit the website.

The conference is supported by the American Foundation for Suicide Prevention, Centerstone Kentucky, Norton Healthcare and Passport Health Plan.

The UofL Depression Center is Kentuckiana’s leading resource for depression and bipolar disorder treatment, research and education. It is a charter member of the National Network of Depression Centers, a consortium of leading depression centers that develops and fosters connections among members to advance scientific discovery and provide stigma-free, evidence-based care to patients with depressive and bipolar illnesses.

 

 

October 25, 2018

University of Louisville Joins Prestigious International Group Advising the United Nations on Sustainability

UofL also to be founding member for US network.
University of Louisville Joins Prestigious International Group Advising the United Nations on Sustainability

UofL President Neeli Bendapudi

What does the University of Louisville have in common with the Columbia University in New York, Princeton University and Oxford University in the United Kingdom? All are members of the United National Sustainable Development Solutions Network.

“Inclusion in this international effort recognizes our efforts over the decades to impact our world in a meaningful way when it comes to sustainability,” said UofL President Neeli Bendapudi today in announcing UofL’s membership at the Louisville Sustainability Symposium, which UofL is hosting for the first time.

“From the Conn Center looking for renewable energy sources and our university-wide efforts to reduce our carbon footprint to our recent creation of the Envirome Institute that focuses on health sustainability, we have a long history of trying to leave a better planet.”

UofL joins just 684 universities and research centers throughout the world that advise the United National on sustainable development.

Additionally, UofL will be a founding member of the U.S. Solutions Network later this year.

“The UN Sustainable Development Solutions Network is honored to welcome the University of Louisville to the global network,” said Columbia University Professor Jeffrey D. Sachs, advisor to the Secretary General of the UN and Director of the Sustainable Development Solutions Network. “The SDSN looks forward to working closely with the Envirome Institute and city and community leaders to advance the Sustainable Development Goals. Our efforts together will help to advance wellbeing in Louisville and around the world.”

The national and regional networks support the localization of the 17 goals set out by the UN and agreed to by 193 nations in 2015. Local networks will promote long-term pathways for sustainable development, promote high-quality education and research collaboration for sustainable development, and support governments in understanding and addressing the challenges of sustainable development.

Through these efforts, the networks are working to create a future in which poverty has been eradicated, the planet is protected and people are ensured the ability to enjoy peace and prosperity.

“We feel a tremendous sense of responsibility to be a founding member of this nation’s grass-roots effort,” Bendapudi said. “All of us at the university in collaboration with our community partners look forward to spearheading efforts to better understand how our environment, in the broadest sense of the word, impacts us as individuals.”

Led by Aruni Bhatnagar, Ph.D., the Smith and Lucille Gibson Chair in Medicine, the UofL Envirome Institute takes a holistic approach to researching how the human-environment interrelationship impacts peoples’ lives. In addition to building on Bhatnagar’s pioneering work establishing the field of environmental cardiology, UofL will incorporate community engagement and citizen science to introduce a singular, new approach to the study of health.

“Our researchers, staff and students will explore new concepts associated with examining the elements of a single person’s overall environment and determine how that affects their lives. The impact this will have will be felt well beyond Louisville,” Bendapudi said.

Newest institute named in honor of Christina Lee Brown

Newest institute named in honor of Christina Lee Brown

Christina Lee Brown (third from the right)

In recognition of her support, the University of Louisville will rename its most recently created institute to The Christina Lee Brown Envirome Institute. The UofL Board of Trustees voted on the name change today.

“I cannot think of a better way to honor Christie for her tremendous generosity that has allowed the institute to become a reality and to get off to such a strong start,” said UofL President Neeli Bendapudi.

In May, Brown committed $5 million in support of the institute, which takes a holistic approach to researching how the human-environment interrelationship impacts peoples’ lives. In addition to building on the pioneering work of Aruni Bhatnagar, Ph.D., that established the field of environmental cardiology, UofL will incorporate community engagement and citizen science to introduce a singular, new approach to the study of health. Bhatnagar is the institute’s director, as well as the Smith and Lucille Gibson Chair in Medicine.

The Christina Lee Brown Envirome Institute develops new infrastructure for transdisciplinary knowledge, bridging academic research with community engagement it transforms the city of Louisville into an urban laboratory and establishes the university as a repository of knowledge about the envirome. The Christina Lee Brown Envirome Institute offers global leadership in developing new models of living by making decisions through the lens of health.

‘Think Pink’ in Shepherdsville on Oct. 23 honors breast cancer survivors

‘Think Pink’ in Shepherdsville on Oct. 23 honors breast cancer survivors

The Paroquet Springs Conference Centre in Shepherdsville will be the site of the "Think Pink" celebration of breast cancer survivors on Oct. 23.

The Kentucky Cancer Program at the University of Louisville James Graham Brown Cancer Center is teaming up with the Bullitt County Health Department to honor breast cancer survivors in October.

The “Think Pink” event will be held beginning at 5 p.m., Tuesday, Oct. 23, at the Paroquet Springs Conference Centre, 395 Paroquet Springs Dr., Shepherdsville.

Former Kentucky First Lady Judy Patton and breast cancer survivor Tabitha Spencer, RT,, R(M), of Baptist Health Louisville, will speak. Health information booths also will be set up on a variety of topics related to breast cancer.

The event is free but RSVPs are required by calling the Bullitt County Health Department at 502-955-5355.

For more information, contact Pam Temple of the Kentucky Cancer Program at 502-852-6318 or pam.templejennings@louisville.edu.

 

Tackling opioid misuse among older adults

Tackling opioid misuse among older adults

Joe D’Ambrosio instructs a group of students

The majority of older adults take at least one prescription medication daily, and according to 2016 data from the Substance Abuse and Mental Health Services Administration, more than 500-thousand Medicare Part D beneficiaries take opioids, with the average dose far exceeding the recommended amount. This can lead to health risks such as breathing complications, confusion, drug interaction problems and increased risk of falls.

To help tackle the issue of opioid misuse in older adults, the Institute for Sustainable Health & Optimal Aging at the University of Louisville has been working with individuals in rural Kentucky who are involved in the institute’s Flourish Program, which is designed to deliver interdisciplinary care coordination to those with chronic conditions.

Of the 154 patients who have received services, medication management issues related to opioid prescriptions and interactions with other medications were a factor with more than 90 patients. Medication safety also proved to be a problem, with family members or caregivers taking opioids from patients in at least 10-percent of cases.

The institute recently received supplemental federal funding to their Geriatrics Workforce Enhancement Program grant, specifically to expand work in Bullitt, Henry, Oldham, Shelby, Spencer and Trimble counties related to opioids and older adults. This effort also will be offered in Jefferson, Barren, Metcalf and Hart counties.

“This additional funding will allow us to dramatically increase our ability to screen for potential opioid misuse and to educate patients, students and practitioners on best practices for pain management for older adults,” said Anna Faul, Ph.D., the institute’s executive director.

Joe D’Ambrosio, Ph.D., the institute’s director of health innovation & sustainability and assistant professor at the UofL School of Medicine will lead an interdisciplinary clinical team of faculty from nursing, social work and counseling psychology to serve as mental health clinicians for the project.

He said the institute is developing a new program to train students and clinicians on how to identify and treat opioid-related substance abuse among older adults. The programming also will be offered to community mental health partners including Centerstone, the region’s largest mental health care provider.

Researchers earn federal funding to explore impact of environment on diabetes, obesity

Researchers earn federal funding to explore impact of environment on diabetes, obesity

UofL President Neeli Bendapudi, Ph.D.

A team of researchers at the University of Louisville has garnered $16.4 million from the National Institutes of Health to explore several angles related to how different aspects of our environment contribute to the development or health impacts of diabetes and obesity.

“More than 90 million adults in the United States are obese and more than 30 million adults suffer from diabetes. Our faculty, staff and students work every day to understand the causes and impacts of both so that we can develop the next generation of preventions, cures and treatments,” said UofL President Neeli Bendapudi, Ph.D. “This group of dynamic researchers now is looking at how our environment, in the broadest sense of the word, plays a role. This understanding has the potential to change not just people in Louisville, but literally the world. This is some of what makes UofL a great place to learn, work and invest.”

Aruni Bhatnagar, Ph.D., director of the UofL Diabetes and Obesity Center and the recently created Envirome Institute, which houses the Diabetes and Obesity Center, earned a competitive renewal grant that provides funding for essential core programs for all researchers in the center. Additionally, the center grant helps set the director of the research with an emphasis on metabolic and inflammatory mechanisms leading to diabetes, obesity and insulin resistance; stem cell biology; and environmental determinants of cardiometabolic disease. This marks the second successful five-year renewal that Bhatnagar has earned.

Petra Haberzettl, Ph.D., assistant professor of medicine, and Bradford Hill, Ph.D., associate professor of medicine, received funding to examine the effects of air pollution on stem cell health.

Jason Hellman, Ph.D., assistant professor of medicine, received funding to explore how exercise can reduce inflammation. His previous work has shown previously uncovered new mechanisms of sustained inflammation in atherosclerotic lesions in diet-induced obesity.

Matt Nystoriak, Ph.D., assistant professor of medicine, is examining how the heart talks to blood vessels to increase blood flow during exercise.

Timothy O’Toole, Ph.D., assistant professor of medicine, received support to study how the molecule carnosine can be activated in protecting humans against airborne particulate matter.

 

Where was this water before it was in my beer?

New location and time for Beer with a Scientist! Oct. 17
Where was this water before it was in my beer?

Robert Bates

Kentucky has an abundant supply of water – sometimes too much. So it may seem like we need not worry about our water use as much as people living in drier areas such as California or Arizona.

That is not necessarily the case.

At the next Beer with a Scientist, Robert Bates, a water expert and nearly 30-year employee at Louisville Metro Sewer District, will explain that, while it is plentiful here in Kentucky, water still is a precious commodity and recycling it makes sense. He will discuss water recycling in the United States, the “Louisville water cycle” and how some local organizations are recycling water to make beer.

Now an operations specialist with GRW, an engineering consulting firm based in Lexington, Bates was in operations management for more than 10 years at MSD’s Morris Forman Water Quality Treatment Center, the largest wastewater treatment facility in Kentucky. He also is a past president of the Water Environment Association of Kentucky/Tennessee (WEAKT) and has co-authored several peer-reviewed scientific publications on wastewater.

“There is no new water, so the more we can do to protect this most vital resource, the better,” Bates said. “Plus, no water, no beer!”

His talk begins at 7 p.m. on Wednesday, Oct. 17, at Holsopple Brewing, 8023 Catherine Ln., Louisville. A 30-minute presentation will be followed by an informal Q&A session.

Enjoy this popular event, organized by Louisville Underground Science, at its earlier time and new location. Admission is free. Purchase of beer, other beverages or menu items is not required but is encouraged.

Organizers continue to encourage Beer with a Scientist patrons to drink responsibly.

UofL cancer researcher Levi Beverly, Ph.D., created the Beer with a Scientist program in 2014 as a way to bring science to the public in an informal setting. At these events, the public is invited to enjoy exactly what the title promises:  beer and science.

Special Olympics gold medalist receives clinical care at UofL

Special Olympics gold medalist receives clinical care at UofL

Dionte Foster, left, trains at the UofL Bass-Rudd Tennis Center on his new prosthetic leg.

For the first time in years, Dionte Foster played tennis on two legs.

The Special Olympics gold medalist traveled to Louisville last week from his native St. Kitts in the Caribbean to receive pro bono clinical care from University of Louisville Physicians and a sports prosthesis from Louisville Prosthetics that would retail for about $61,000.

While training for the 2015 Special Olympics World Summer Games in Los Angeles, Foster was diagnosed with osteosarcoma, a type of bone cancer, which required his left leg to be amputated above the knee.

“It was devastating because tennis is my world. It almost felt like it was the end of life,” Foster said. “But, I became determined to not give up. I’ve been living life to the fullest ever since and trying to be strong for me and my mom.”

Foster, 24, not only lost his leg, but the cancer had spread to his lungs, requiring surgery and chemotherapy, which he received in New York because adequate treatment was not available in the Caribbean.

He continued to play tennis, albeit with great difficulty, on one leg. Special Olympics officials started raising money to get Foster a prosthetic leg and news of the effort reached Matt Holder, MD, MBA, chief executive officer of the Lee Specialty Clinic in Louisville, who also serves as the global medical adviser for Special Olympics.

Seeking help, Holder contacted Priya Chandan, MD, MPH, assistant professor in the Division of Physical Medicine & Rehabilitation in UofL’s Department of Neurological Surgery and a Special Olympics Kentucky board member. Through the UofL connection, Matthew Adamkin, MD, UofL Physicians-Physical Medicine & Rehabilitation, was tapped to provide care at no cost to Foster. Adamkin prescribed the prosthetic and worked closely with licensed prosthetist and pedorthotist Wayne Luckett of Louisville Prosthetics to ensure it would meet Foster’s needs. Luckett obtained specialized components for the prosthetic through donations from Freedom Innovations, Martin-Martin Bionics, Endolite North America and American Prosthetics.

Foster must learn to trust his prosthetic, placing more weight on it in order to improve his movement.

“It’s hard work to wear a prosthetic,” Luckett said. “It requires 100-percent more energy to move compared to able-bodied people. He’s already an athlete and in good shape, but we’re going to get him in better shape so he can return to the tennis courts and be competitive again.”

Also during his time in Louisville, Foster underwent a CT scan of his chest with support from the Mary Jane Gift Quality of Life Fund through the UofL James Graham Brown Cancer Center. The fund was established by Tommy and Alex Gift to honor their mother after she lost her life to cancer.

Foster received good news; his CT scan showed no evidence of cancer. Megan Nelson, MD, UofL-Physicians-Physical Medicine & Rehabilitation, who specializes in cancer rehabilitation, helped organize the CT scan and arranged for Foster to meet with a sarcoma support group.

After a couple days of physical therapy, Foster trained on the tennis court with Rex Ecarma, UofL men’s tennis head coach, and Jeff Bourns, an amputee and Adapted Touring tennis player who holds a Top 5 World Rank (Category A) on the TAP World Tour.

The effort by multiple organizations to improve Foster’s mobility and help him return to competitive tennis was extraordinary, Adamkin said.

“I’ve never been a part of anything like this,” Adamkin said. “Dionte’s strides have been remarkable. With every day, he will get more confident and secure with the prosthesis.”
Foster said he is determined to make his story an example that inspires others to overcome adversity.

“It’s a game changer,” Foster said of receiving his new leg. “This has been an honor and I’m really thankful. It’s amazing to know I have a leg to go back home with and put my crutches aside.”

Professor Emeritus among honorees of optimal aging awards

Professor Emeritus among honorees of optimal aging awards

2018 Gold Standard Award winners

At age 96, Seymour “Sy” Slavin is still active speaking to groups in the community. A professor emeritus of the University of Louisville Kent School of Social Work, Slavin recently was recognized as one of 15 awardees of the 2018 Gold Standard Awards for Optimal Aging.

Now in its seventh year, UofL’s Institute for Sustainable Health and Optimal Aging hosted the awards this month, honoring Slavin in the educator category.

After teaching more than 30 years, Slavin went on to create and serve as the first director of the Kentucky Labor Institute. He lectures on topics ranging from Einstein’s views on the relationship of science and religion to the role of the administrative state in a democracy.

The Gold Standard awards honor individuals age 85 and older who lead flourishing lives, said Anna Faul, Ph.D., executive director of the institute.

“We do not have to be free of aging-related challenges to age optimally. It is our ability to flourish and live our best lives every day in the face of these challenges. This year’s outstanding cohort of awardees and nominees are true inspirations,” she said.

Fifteen awardees along with 58 other nominees were recognized at a luncheon on Sept. 7 sponsored by Hosparus Health. The event corresponds with Optimal Aging Month – an effort dedicated to promoting the positive view that aging is an opportunity, not a disease.

“The award winners demonstrate that while aging optimally looks different for every person, we can all strive to continue living our best lives at every stage,” said Christian Furman, M.D., medical director of the institute.

“Hosparus Health applauds the institute for recognizing that aging is a part of life. As an organization dedicated to improving the quality of life, we are honored to be a part of this event,” said Phil Marshall, president and CEO of Hosparus Health.

The complete list of 2018 category award winners include:

  • Elmer Lucille Allen, Category: Outstanding Individual, Age: 86
  • Mary Atherton, Category: Years of Wisdom, Age: 100
  • Elizabeth Bealmear, Category: Years of Wisdom, Age: 91
  • Les Brooks, Category: Never too Late, Age: 86
  • Thomas Cork, Sr., Category: Outstanding Individual, Age: 92
  • Don & Patsy Hall, Category: Outstanding Couple, Age: 87 & 87
  • Father Simon Herbers, Category: Compassion, Age: 97
  • Beatrice Huff, Category: Kentucky, Age: 89
  • Margot Kling, Category: Social Justice, Age: 92
  • Margaret Martel, Category: Years of Wisdom, Age: 106
  • Emma Patria Pedroso Iglesias, Category: New Beginnings, Age: 85
  • Dorothy Roehrig, Category: Years of Wisdom, Age: 100
  • William T. Shumake, Category: Leadership, Age: 92
  • Dr. Seymour Slavin, Category: Educator, Age: 96

Technology, along with therapy, helps individuals with chronic spinal cord injuries voluntarily take steps

New research published in the New England Journal of Medicine documents the effectiveness of epidural stimulation with locomotor training following chronic, complete spinal cord injury in restoring brain-to-spine connectivity, long thought to be impossible
Technology, along with therapy, helps individuals with chronic spinal cord injuries voluntarily take steps

Kelly Thomas, Claudia Angeli, Ph.D., Jeff Marquis and Susan Harkema, Ph.D.

Of four research participants living with traumatic, motor complete spinal cord injury, two are able to walk over ground with epidural stimulation following epidural stimulation paired with daily locomotor training. In addition, all four participants achieved independent standing and trunk stability when using the stimulation and maintaining their mental focus. The study was conducted at the Kentucky Spinal Cord Injury Research Center at the University of Louisville (UofL) and was published online early, and will appear in the Sept. 27 issue of New England Journal of Medicine. The study was funded by the Leona M. and Harry B. Helmsley Charitable Trust, University of Louisville Hospital and Medtronic plc.

See video story

This ground-breaking progress is the newest development in a string of outcomes at UofL, all pointing to the potential of technology in improving quality of life – and even recovery – following spinal cord injury. This latest study builds on initial research published in The Lancet in 2011 that documented the success of the first epidural stimulation participant, Rob Summers, who recovered a number of motor functions as a result of the intervention. Three years later, a study published in the medical journal Brain discussed how epidural stimulation of the spinal cord allowed Summers and three other young men who had been paralyzed for years to move their legs. Later research from UofL demonstrated this technology improved blood pressure regulation.

“This research demonstrates that some brain-to-spine connectivity may be restored years after a spinal cord injury as these participants living with motor complete paralysis were able to walk, stand, regain trunk mobility and recover a number of motor functions without physical assistance when using the epidural stimulator and maintaining focus to take steps,” said author Susan Harkema, Ph.D., professor and associate director of the Kentucky Spinal Cord Injury Research Center at the University of Louisville. “We must expand this research – hopefully, with improved stimulator technology – to more participants to realize the full potential of the progress we’re seeing in the lab, as the potential this provides for the 1.2 million people living with paralysis from a spinal cord injury is tremendous.”

Progress for Individuals Living with Paralysis

The American Spinal Injury Association Impairment Scale (AIS) was used to classify the spinal cord injuries of each of the four participants. When the four participants joined the study, they were at least 2.5 years post injury. They were unable to stand, walk or voluntarily move their legs. Eight to nine weeks prior to the implantation of an epidural stimulator, they started daily locomotor training – manual facilitation of stepping on a treadmill – five days per week for two hours each day. Although there were no changes to their locomotor abilities prior to the implant, following the epidural stimulation participants were able to step when the stimulator was on and the individual intended to walk. Participants 3 and 4 were able to achieve walking over ground – in addition to on a treadmill – with assistive devices, such as a walker and horizontal poles for balance while the stimulator was on.

“Being a participant in this study truly changed my life, as it has provided me with a hope that I didn’t think was possible after my car accident,” said Kelly Thomas, a 23-year-old from Florida, also referred to as Participant 4. “The first day I took steps on my own was an emotional milestone in my recovery that I’ll never forget as one minute I was walking with the trainer’s assistance and, while they stopped, I continued walking on my own. It’s amazing what the human body can accomplish with help from research and technology.”

Jeff Marquis, a 35-year-old Wisconsin native who now lives in Louisville, was the first participant in this study to attain bilateral steps. “The first steps after my mountain biking accident were such a surprise, and I am thrilled to have progressed by continuing to take more steps each day. In addition, my endurance has improved, as I’ve regained strength and the independence to do things I used to take for granted like cooking and cleaning,” said Marquis, who is participant 3 in New England Journal of Medicine study. “My main priority is to be a participant in this research and further the findings, as what the University of Louisville team does each day is instrumental for the millions of individuals living with paralysis from a spinal cord injury.”

“While more clinical research must be done with larger cohorts, these findings confirm that the spinal cord has the capacity to recover the ability to walk with the right combination of epidural stimulation, daily training and the intent to step independently with each footstep,” said Claudia Angeli, Ph.D., senior researcher, Human Locomotor Research Center at Frazier Rehab Institute, and assistant professor, University of Louisville’s Kentucky Spinal Cord Injury Research Center.

Advancements for Spinal Cord Injury Community

This research is based on two distinct treatments:  epidural stimulation of the spinal cord and locomotor training. Epidural stimulation is the application of continuous electrical current at varying frequencies and intensities to specific locations on the lumbosacral spinal cord. This location corresponds to the dense neural networks that largely control movement of the hips, knees, ankles and toes. Locomotor training aims to ultimately retrain the spinal cord to “remember” the pattern of walking by repetitively practicing standing and stepping. In a locomotor training therapy session, the participant’s body weight is supported in a harness while specially trained staff move his or her legs to simulate walking while on a treadmill.

“We are seeing increasing interest in the use of neuromodulation procedures and technologies such as epidural stimulation in the treatment of spinal cord injury and restoration of locomotor, cardiovascular and urodynamic functions,” said Maxwell Boakye, M.D., M.P.H., M.B.A., chief of spinal neurosurgery at the University of Louisville and clinical director of the Kentucky Spinal Cord Injury Research Center. “Epidural stimulation is likely to become a standard treatment with several improvements in design of the device to target more specific neurological circuits.”  

For more information on epidural stimulation research, visit Victoryoverparalysis.org.

 

September 24, 2018

GEMS: Ushering homegrown talent into medicine for 30 years

Guaranteed Entrance to Medical School (GEMS) smooths the path for talented Kentucky students into a medical career
GEMS:  Ushering homegrown talent into medicine for 30 years

Sunshine Smoot, M.D.

When she was in 8th grade, Breathitt County native Sunshine Smoot decided she wanted to be a pediatrician. As a Governor’s Scholar after her junior year in high school, she happened to overhear one of the instructors talking with another student about GEMS, a program that provides gifted high school students with Guaranteed Entrance to Medical School (GEMS) at the University of Louisville even before they start college.

“I remember her explaining what a one-of-a-kind program GEMS was, how those selected had unique opportunities in undergrad that others would not have until much later in their medical careers and how the GEMS were a close-knit group seen around campus together,” Smoot said. “Overhearing that one conversation affected my whole life.”

For 30 years, GEMS has provided mentoring and support for nearly 300 academically talented youth from across Kentucky interested in becoming physicians by providing a clear path to complete college and enter medical school. Each academic year, about 10 students are admitted to the program as freshmen entering UofL.

Established in 1988, GEMS paves the way for the students selected for the program as they enter UofL as undergraduates knowing they will have automatic admission to the UofL School of Medicine as long as they maintain certain academic standards. In addition, GEMS students have the opportunity to shadow practicing physicians and faculty, participate in seminars, serve the Louisville community and build relationships with other students who have the goal of becoming a physician.

The students retain their automatic admission to the UofL School of Medicine as long as they have maintained a 3.4 cumulative and science grade point average in undergraduate work, scored at or above the national mean on each section of the Medical College Admissions Test (MCAT), and participated fully in program activities.

Kevin Trice, M.D., M.B.A., now a director of sleep medicine at Baptist Hospital in Madisonville, Ky., said GEMS gave him the confidence and freedom to pursue medicine.

“It completely changed my trajectory. I was interested in medicine, but planned to pursue engineering since it was easier and I had a better chance,” Trice said. “Once I was accepted, it relieved me of the anxiety and stress common in undergraduate pre-med students.”

James Frazier, M.D., was a member of the 1990 GEMS class and graduated from the UofL School of Medicine in 1998. Now the vice president of medical affairs at Norton Healthcare, Frazier said the GEMS program was life changing.

“I owe everything to GEMS. They took a chance on me right out of high school. It took a lot of pressure off that I saw my future classmates going through,” Frazier said. “You would see those who were trying to get in, how stressed they were about MCAT and maintaining their GPA. It definitely gave me an advantage not having to worry about maintaining perfect grades.”

Frazier said the freedom from stress allowed him to broaden his undergraduate education.

“Because of that reduced stress, I got to take more well-rounded classes – history, economics, finance – than if I had to maintain a 4.0 GPA. It helped me when I started private practice to have a little knowledge about the business world and how to run practice,” Frazier said.

Scott Sullivan, M.D., a member of the 1989 GEMS class and 1996 alumnus of the UofL School of Medicine, credits the program with providing resources he needed to enter medicine.

“I doubt I would be in medicine without the program. Living in a rural area and never having much exposure to medicine, I lacked mentors and direction. The program provided both, which proved to be invaluable,” said Sullivan, who is from Ballardsville, Ky.

Now an ob/gyn and specialist in maternal-fetal medicine, Sullivan is a professor at Medical University of South Carolina in Charleston, S.C.

“Having access to dedicated and experienced mentors at the age of 18 was incredibly helpful,” Sullivan said. “They got me on the right track very quickly. They gave mentorship not only about how to become a physician, but how to be interested in public health, education and community involvement.”

Another advantage for students who have participated in the program is the relationships they built with colleagues and mentors that enrich their college and medical school experience, including physicians, researchers and faculty in the School of Medicine.

“The most valuable part is the people you meet and you are with for four years in undergrad and medical school. For those eight years you are extremely tight. I am still in close contact with all the people in GEMS with fair regularity,” Frazier said. “We have a 20th reunion coming up and I am looking forward to seeing them. Having that network of people here in town is invaluable.”

“The program was very forward thinking at the time as a way to keep Kentucky physicians in the state, and I believe they have done a pretty good job,” Frazier said. “It was a very progressive thing for UofL to have done 30 years ago, and I’m happy the school has supported it for so long.”

Smoot was admitted to the GEMS program in 1997 and graduated from UofL School of Medicine in 2006. She now is a pediatrician at Juniper Health in Campton, Ky.

“I often wonder if I had not happened to overhear a chance conversation, being from Eastern Ky., would I have gone to UofL for my undergraduate years, and then on to UofL medical school?” Smoot said. “Looking back now, I can’t imagine a different past, and I certainly would regret missing out on the friendships I made at UofL 20 years ago that still mean the world to me.”

 

GEMS BY THE NUMBERS

Number of students participating in GEMS 1988-2018:     290

Number of GEMS students who have graduated from UofL School of Medicine:   148

Number of GEMS students currently enrolled in UofL School of Medicine:  27

Number of GEMS students enrolled or graduated from another school of medicine:  19

Number of GEMS students currently enrolled in UofL as undergraduates:  39

Number of GEMS students who were Kentucky Derby Festival princesses:  5 (1 Queen)

Number of Kentucky counties represented by GEMS students:  49

Number of GEMS students who have completed or are enrolled in MD/PhD programs:  6

 

 

September 20, 2018

Optimal aging institute creates new index to measure quality of life for older adults

Optimal aging institute creates new index to measure quality of life for older adults

Anna Faul, Ph.D.

A new assessment tool developed by the University of Louisville’s Institute for Sustainable Health & Optimal Aging aims to measure functionality and quality of life for older adults with multiple chronic conditions (MCC).

The Flourish Index is a set of evidence-based, quality of care indicators across six determinants of health: biological, psychological, health behaviors, health services, environmental and social. Some specific factors include preventive care, medication management, process of care measures, promotion of health behaviors, transportation, isolation, income challenges and food access.

The index resulted from the institute’s research associated with the Geriatric Workforce Enhancement Program (GWEP).

Executive Director of the institute, Anna Faul, Ph.D., said the need for a broader assessment tool was clear.

“The majority of other indicators are disease and setting-specific and don’t fully account for the functional and quality of life factors affecting older adults with MCC,” she said. “Other scales and measures often do not capture a patient’s life satisfaction but focus solely on medical improvement.”

The federal Health Resources and Services Administration (HRSA) has awarded UofL’s institute with grant funding to lead the two-day training Sept. 20 – 21 for other GWEP programs at the University of Iowa, Rush University, University of Utah and Indiana University.

The workshop will focus on the customization of the Flourish Index - specifically, how to align it with the Medicare Annual Wellness Visit, how the index can be used to facilitate primary care transformation and how it can be implemented by the health care workforce in collaboration with community-based services. Central to the conversation will be the index’s role in demonstrating the sustainability of comprehensive care coordination.

“We are honored by the recognition from HRSA to teach other GWEP programs about our Flourish Index,” Faul said. “The GWEP programs attending the workshop are united in our interest to develop new measures that fully capture the holistic health and well-being of patients. Being selected to host this workshop demonstrates that people are recognizing the exciting and transformative potential of our Flourish Index,” she said.

This workshop is part of the institute’s annual effort to celebrate Optimal Aging Month. Learn more about events happening in September.

 

Epidural stimulation leads to improved regulation of blood pressure in spinal-cord-injured people

Research from UofL published in JAMA Neurology shows recovery of cardiovascular function in spinal-cord-injured people sustained following epidural stimulation training
Epidural stimulation leads to improved regulation of blood pressure in spinal-cord-injured people

Stefanie Putnam and Glenn A. Hirsch, M.D.

For the first time since 2009, Stefanie Putnam is able to prepare – and eat – meals for herself, put the vest on her service dog, Kaz, and drive herself to activities with her horse without losing consciousness or gasping for breath.

“My whole life has opened up for me again!” Putnam said.

A C4 spinal cord injury in 2009 left Putnam paralyzed from the neck down and suffering from chronic low blood pressure. She relied on medication and tight corsets to maintain her blood pressure, but she still passed out five or six times a day.

Her new lease on life is the result of spinal cord epidural stimulation (scES) she received as a participant in research at the University of Louisville’s Kentucky Spinal Cord injury Research Center (KSCIRC) to aid recovery for individuals with spinal cord injury. Research published today in JAMA Neurology describes the improvements Putnam and three other research participants experienced in blood pressure and heart rate regulation during and after scES. All four participants had chronic, complete cervical spinal cord injury, persistent low resting blood pressure and blood pressure decrease when sitting up prior to receiving scES.

[Video story on Youtube]

“From a quality of life perspective, orthostatic hypotension, or low blood pressure when sitting up, is truly life limiting,” said Glenn A. Hirsch, M.D., a cardiologist with the UofL School of Medicine and co-author of the study.

Spinal cord epidural stimulation uses an implanted electrode array to deliver electrical signals to the lumbar spine. For this study, research participants received stimulation using specific configurations selected to target cardiovascular function, monitoring blood pressure and cardiovascular function throughout, for an average of 89 daily, two-hour sessions. Earlier research showed the benefits of scES in controlling cardiovascular function during stimulation, but this data reveals participants’ blood pressure and heart rate remained stabilized between sessions, showing an enduring effect.

“What was most surprising was that only having it on for a few hours a day, we were noticing participants having normal blood pressure through longer periods of each day,” Hirsch said. “We are noticing it now across the research participants who had that problem, that there is a prolonged stabilizing effect even after the stimulator is turned off.”

Since receiving scES for her cardiovascular symptoms, Putnam said she enjoys increased independence and alertness, and she no longer needs medication to increase her blood pressure.

“I am an active member in my own life instead of merely existing. I am really living! I can prepare and cook my own meals. I can feed myself and carry on a conversation. Without the disruption of passing out or gasping for breaths in the middle of a task or having to stop and be back in my chair for two hours at a time, I can accomplish so much more. Now I can live my best life with energy to focus on my future.” Putnam said.

Research at UofL using scES, led by Susan Harkema, Ph.D., associate director of KSCIRC and professor of neurosurgery at UofL, began with the goal of restoring motor function. However, researchers and participants soon noticed stimulation led to improvements in cardiovascular and autonomic systems as well.

“In our motor system studies, we observed that we could actually regulate blood pressure without activating the motor system. That launched us into another area of research,” Harkema said. “Many people don’t realize that walking in many cases is not really the aspect that makes their daily lives most difficult because they have cardiovascular dysfunction and problems with respiratory, bowel, bladder, and sexual function. All of those things are disrupted so every day is incredibly difficult for people with spinal cord injury.”

In ongoing research to explore further the life-enhancing effects of epidural stimulation, the UofL researchers are conducting a six-year study with 36 participants with chronic, complete spinal cord injuries.

To learn more about supporting and participating in spinal cord injury research at UofL, visit the university’s Victory Over Paralysis website:  victoryoverparalysis.org

Today’s published research, “Epidural Spinal Cord Stimulation Training and Sustained Recovery of Cardiovascular Function in Individuals with Chronic Cervical Spinal Cord Injury,” was supported by the Craig H. Neilsen Foundation, The Leona M. and Harry B. Helmsley Charitable Trust, University of Louisville Hospital, Christopher & Dana Reeve Foundation and Medtronic Plc.

 

September 17, 2018

Louisville donor provides $500K gift to UofL for type 1 diabetes research

William Marvin Petty, M.D., Research Fund will support next step for promising research to improve pancreatic islet cell transplantation success
Louisville donor provides $500K gift to UofL for type 1 diabetes research

William Marvin Petty, M.D.

JoAnn Joule’s father, William Marvin Petty, M.D., suffered from diabetes for many years. A 1952 graduate of the University of Louisville School of Medicine, Petty served as Jefferson County Coroner from 1962 to 1974 and was a family physician in Fern Creek for 43 years.

Joule’s son lives with type 1 diabetes.

To honor her late father and help improve the lives of those with type 1 diabetes, Joule has given $500,000 to the University of Louisville Foundation to establish the William Marvin Petty, M.D., Research Fund. The fund is designated to support type 1 diabetes research at the UofL School of Medicine.

“I saw the toll diabetes took on my dad, and now my son is faced with the same disease,” Joule said. “I was not happy that medical research has not come up with anything new in the 40 years my son has been suffering. I am putting my assets behind the UofL research team.” 

That research team includes Haval Shirwan, Ph.D., and Esma Yolcu, Ph.D., of the UofL Department of Microbiology and Immunology, who are working to develop techniques to prevent and treat type 1 diabetes with particular focus on transplantation of islet cells.

Type 1 diabetes is a chronic autoimmune disease in which the pancreas does not produces enough insulin, a hormone required to convert glucose to energy in the body. There is no cure for type 1 diabetes, and standard treatment involves regular injections of insulin, which is far from keeping blood sugar in balance.

Insulin is produced in the pancreas by a type of cells called islet cells. Individuals with type 1 diabetes have too few or altogether lack the type of islet cells that produce insulin to keep glucose at the proper level. In recent years, physicians have developed a treatment in which they transplant the needed islet cells into a patient. However, the patient’s immune system often rejects the transplanted islet cells over time, attacking and killing them. To keep the transplanted cells alive, patients must take immunosuppression medications, which have a number of undesirable side effects.

At UofL, Shirwan and Yolcu have pioneered a process to create a manufactured protein known as Fas ligand (FasL), to protect the islet cells from destruction by the patient’s immune system. This process, patented by the UofL Office of Technology Transfer, is called ProtExTM technology. ProtEx is used to create FasL, which is then applied to islet cells to protect them from destruction by the immune system once they are transplanted into the patient.

Preclinical research has shown that FasL is highly effective in protecting islet cells in small animal models. However, additional testing is necessary before the therapy can be used in humans.

“Ms. Joule’s contribution will enable us to achieve an important milestone for further development of the technology towards clinical translation by performing efficacy and safety studies. We are very grateful for that support,” Shirwan said.

Greg Postel, M.D., executive vice president for health affairs at UofL, said the university is grateful for the contribution to research by and in honor of members of the Louisville community.

“We are extremely pleased that Ms. Joule has elected to support this very promising research at the University of Louisville,” Postel said “We believe her donation will allow this research to improve the lives of type 1 diabetic patients sooner rather than later.”

 

September 10, 2018

Good sleep wards off cancer

UofL psychologist explains how disrupting your biological rhythm can lead to cancer at Beer with a Scientist, Sept. 12
Good sleep wards off cancer

Liz Cash, Ph.D.

When did you last travel overseas? Do you remember how long it took for your sleep cycle to return to normal?

That feeling of jet lag signals a disruption to your naturally occurring circadian, or daily, biological rhythms. Circadian rhythms help our bodies know when to eat, when to sleep and when to be active. They also control the life cycle of every cell in the body.

“When our circadian rhythms become disrupted, humans and animals are at greater risk for the rise and spread of cancer,” said Liz Cash, Ph.D., a clinical health psychologist and director of research for the Department of Otolaryngology Head and Neck Surgery and Communicative Disorders at the University of Louisville. She also holds adjunct positions in the Departments of Psychological and Brain Sciences, and Family and Geriatric Medicine.

At the next Beer with a Scientist, Cash will deliver, “Tick-tock:  How disrupting your body clock and sleep cycle gives rise to cancer … and what you can do about it.” Her talk will include evidence of how circadian disruption contributes to cancer incidence and progression, as well as some simple, effective strategies to maintain or regain good circadian rhythms. 

The talk begins at 8 p.m. on Wednesday, Sept. 12, at Against the Grain Brewery, 401 E. Main St. in Louisville. A 30-minute presentation will be followed by an informal Q&A session.

Admission is free. Purchase of beer, other beverages or menu items is not required but is encouraged.

Organizers add that they also encourage Beer with a Scientist patrons to drink responsibly.

UofL cancer researcher Levi Beverly, Ph.D., created the Beer with a Scientist program in 2014 as a way to bring science to the public in an informal setting. At these events, the public is invited to enjoy exactly what the title promises:  beer and science.