Researchers at the University of Louisville have uncovered a cadre of small molecules that tell certain proteins to kill lung cancer cells. The team, led by Chi Li, Ph.D., assistant professor of medicine, published its finding in the April 2014 issue of Molecular and Cellular Biology.

One of the characteristics of lung cancer is the dysregulation of apoptosis, or regulated cell death. Cancer cells are able to survive in the unnatural state.

Proteins from the Bcl-2 family are major regulators of apoptosis. One of them, Bax, sometimes becomes erratic and loses its ability to maintain its killer function, which leads to lung tumor development. The researchers realized that this meant Bax potentially could be part of the cure as well.

The researchers used virtual screening in their study, a process where they ran through a computer program all the possible combinations of molecules that could bind with the Bax proteins to find the best combination. After trying more than 10 million molecules, they found the right one. This Bax-activating small molecule compound kills lung cancer cells as well as inhibits the growth of lung tumors transplanted into mice.

The scientific finding of Li and his team showed it is possible to identify small molecules capable of binding and activating Bax proteins that in turn induce apoptosis in cancerous cells. In the study, published in Molecular and Cellular Biology in April of 2014, Li and his team were able to specifically induce tumor cell death while avoiding normal cell death.

The compound also shows synergy with the widely used chemotherapeutic drug carboplatin. This means that the potential application for this compound in cancer treatment is very broad.

The scientific discovery could form the basis for advanced therapeutic agents for cancer in patients, specifically lung cancer, which is especially prevalent in Kentucky.

The high mortality rate of lung cancer is partially attributed to ineffective therapeutic treatments. This makes it very important for scientists to develop new chemotherapeutic drugs for lung cancer.

Li says it could pave the way for new treatment for other types of cancer as well. “Lung cancer is a really big issue for us. We have a large mortality rate, and that’s one of the reasons we wanted to go after lung cancer,” he said. “We are in the process of trying to expand the application of our discovery onto different types of cancer.”

Li and his team will have the opportunity for that expansion very soon. The National Institutes of Health recently awarded them a grant of $1.5 million to continue their groundbreaking research.

Attention, shopaholics: Here’s your chance to be among the very first to shop The Outlet Shoppes of the Bluegrass.

The Outlet Shoppes of the Bluegrass is teaming with the University of Louisville’s James Graham Brown Cancer Center for an Opening Night VIP Preview from 6-9 p.m., Wednesday, July 30, the evening before the facility opens to the general public.

Patrons will be able to get the jump on the rest of Kentuckiana in shopping at choice retail outlets such as Coach, Brook Brothers, Saks Fifth Avenue Off 5^th, Michael Kors, J Crew, Banana Republic, Nike, Talbots, Under Armour and more. They also will receive a free coupon book with over $300 in savings at many of the 80-plus retailers that make up The Outlet Shoppes of the Bluegrass.

Cost is $50 per person with 100 percent of the proceeds going to the James Graham Brown Cancer Center, the only cancer center in the region to use a unified approach to cancer care, with multidisciplinary teams of physicians working together to guide patients through diagnosis, treatment and recovery.

“We are thrilled to partner with The Outlet Shoppes of the Bluegrass,” Michael Neumann, executive director of development for the cancer center, said. “The pairing of Kentucky’s new premier shopping center with the region’s premier cancer research and treatment center is a great fit.”

Only 3,000 tickets to the event are available and are expected to go fast, Neumann said. Tickets are sold online only at www.shoppingforacure.org. Up to 10 tickets may be purchased per transaction.

The Veritas Curat Foundation is handling ticket sales on behalf of the cancer center, and receipts will be provided via email. The email receipt serves as the ticket to the event, and to be admitted, ticket buyers must bring both a printout of the email receipt and identification that matches the name on the ticket.

A silent auction of packages donated by Shoppes retailers also will be held the night of the VIP Preview, Neumann said. Items up for auction will be posted in advance on the website starting July 28, and online bidding will be available until July 30. On-site bidding on the night of the event will be conducted via smartphone only, he added.

The Outlet Shoppes of the Bluegrass is located at Exit 28 on Interstate 64. For additional information on the Opening Night VIP Preview or the James Graham Brown Cancer Center, contact Neumann at 502-562-4642.

Advanced Cancer Therapeutics (ACT), a privately held company dedicated to bringing new anti-cancer therapies to market, announced June 4 that it has begun clinical trials of PFK-158, a small molecule therapeutic candidate that inactivates a novel cancer metabolism target never before examined in human clinical trials. The U.S. Food and Drug Administration approved Phase 1 dose escalation study is evaluating the safety, tolerability and anti-tumor activity of PFK-158 in cancer patients with solid tumors such as melanoma, lung, colon, breast and pancreatic cancer.

PFK-158 is the first 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3) inhibitor to undergo clinical trial testing in cancer patients. The target, PFKFB3, is activated by oncogenes and the low oxygen state in cancers, stimulates glucose metabolism and is required for the growth of cancer cells as tumors in mice. PFK-158, which has been licensed by ACT from the James Graham Brown Cancer Center at the University of Louisville, inhibits the substrate binding domain of PFKFB3 causing a marked reduction in the glucose uptake and growth of multiple cancer types in mice.

PFK-158 human clinical trials began recruiting patients in May with the first clinical trial site located at the James Graham Brown Cancer Center, a part of KentuckyOne Health. Within weeks of opening the first clinical trial site, ACT was able to open the second clinical trial site at Georgetown University Medical Center in Washington, also in May.

According to Jason A. Chesney, M.D., Ph.D., deputy director of the Brown Cancer Center and a global thought leader and researcher in cancer metabolism, “PFK-158 is not only a first-in-class cancer drug but also the first to target glucose metabolism by inhibiting PFKFB3. This unique mechanism of action has resulted in efficacy against a broad spectrum of human cancers caused by common mutations as well as synergy with targeted agents that are FDA approved for several cancer types.

“As a researcher, it is incredibly rewarding to witness your group's studies move into clinical trials and potentially save the lives of cancer patients,” Chesney said.

“This is a significant milestone for ACT and it supports our dedication to develop significant treatment advancements for cancer patients with first-in-class, potential breakthrough therapeutics like PFK-158,” said Randall B. Riggs, president & CEO of ACT.

About Advanced Cancer Therapeutics (ACT):

ACT is a privately held company dedicated to advancing novel therapeutics for the prevention and treatment of cancer. ACT has successfully established a unique and innovative business model with the University of Louisville’s James Graham Brown Cancer Center whereby ACT is able to obtain exclusive worldwide licenses to novel cancer therapeutics discovered at Brown Cancer Center under preset business terms. ACT then fast-tracks these discoveries, including the selection process for partnership, commercialization and manufacture, to the pharmaceutical industry, and ultimately to the patients who need them. Led by Donald M. Miller, M.D., Ph.D., the Brown Cancer Center employs more than 50 scientists focused on the discovery and advancement of breakthrough cancer therapeutics for patients suffering from cancer. For more information, please visit www.advancedcancertherapeutics.com.

About the James Graham Brown Cancer Center:

The James Graham Brown Cancer Center is a key component of the University of Louisville Health Sciences Center. As part of the region's leading academic, research and teaching health center, the cancer center provides the latest medical advances to patients, often long before they become available in non-teaching settings. The JGBCC is a part of KentuckyOne Health and is affiliated with the Kentucky Cancer Program. It is the only cancer center in the region to use a unified approach to cancer care, with multidisciplinary teams of physicians working together to guide patients through diagnosis, treatment and recovery. For more information, visit our web site, www.browncancercenter.org.

UofL Geriatrics in the Department of Family and Geriatric Medicine at the University of Louisville is calling for nominations for the fourth annual Gold Standard Award for Optimal Aging.

The deadline to submit nominations is 5 p.m., July 15. The award will be presented Sept. 25 at the Annual UofL Geriatrics Gold Standard Award for Optimal Aging Luncheon at the Crowne Plaza Hotel, 830 Phillips Lane.

The Gold Standard Award for Optimal Aging is presented to someone 85 years old or older as of Oct. 1 who is an outstanding model for optimal aging in all areas of life.

“We are seeking people 85-plus who are making the most of whatever their later years bring and who continue to demonstrate great zest for life,” said Christian Davis Furman, M.D., vice chair for geriatric medicine. “The award is presented for optimal aging across the full spectrum of physical health, mental health, social health and spiritual health.”

The nomination process includes submitting information on the nomination form that describes why the nominee qualifies for the award. Nomination forms and information about the luncheon can be found online or obtained by calling (502) 588-4260 or emailing UofLGeriatrics@louisville.edu.

Experts in the use of comprehensive geriatric assessment for hospitalized elders and immunizations in older adults, and the author of the 2012 Beers Criteria – a guide to medication use in elders – will be featured at the 14^th Annual University of Louisville Geriatrics Healthcare Symposium.

The conference will be held Friday, Sept. 19, at the Seelbach Hilton Hotel, 500 S. Fourth St. in Downtown Louisville.

The conference is sponsored by the Division of Geriatrics in the Department of Family and Geriatric Medicine at the University of Louisville and provides information on the latest research and best practices in care for people age 65 and older. Plenary speakers include:

• Michael Malone, M.D., Center for Senior Health & Longevity, Aurora Sinai Medical Center, Milwaukee, addressing the acute care of elderly hospitalized patients.
• Kenneth Schmader, M.D., Geriatrics Division Chief, Duke University School of Medicine, Durham, N.C., providing information on immunizations for elders
• Todd Semla, Pharm.D., Feinberg School of Medicine, Northwestern University, Chicago, speaking on polypharmacy, the overuse or misuse of medications in older adults

Other sessions will be held on POLST: Physician’s Orders for Life, disease screening and prevention, caregiver burnout, injury prevention, exercise, elder abuse, dementia and enhancing independence in the older adult.

The conference is open to health care professionals and students and the public alike. CE credit will be available for physicians, nurses, social workers and other professionals working in the field of geriatrics.

For details, contact the UofL Division of Geriatrics, 502-852-3480 or awburk02@louisville.edu.

Benefactors of a fund to support patients at the James Graham Brown Cancer Center at the University of Louisville are sponsoring their second annual sand volleyball event to raise money for the fund.

In 2013, Alex and Tommy Gift established the Mary Jane Gift Quality of Life Fund at the cancer center in honor of their late mother. The fund helps patients and their families enjoy life while facing a cancer diagnosis.

To benefit the fund, the Gifts are sponsoring The Second Annual Spike It to Cancer Sand Volleyball Tournament at Baxter Jack’s sand volleyball complex, 427 Baxter Ave. on Saturday, June 7. Registration will be held from 1-2:30 p.m., and games will begin at 3 p.m.

Admission is $20 per person. Payment by cash or check will be accepted at the door, or participants can pay by credit card at the cancer center’s secure online link.

“All proceeds from this event go to the Mary Jane Gift Quality of Life Fund that pays for extras provided to our patients and caregivers,” Michael Neumann, executive director of development, said. “Additionally, The Brewery on Baxter Avenue directly across the street from Baxter Jack’s has agreed to donate a portion of all food and beverage sales to us during the event.

“These gifts go a long way in bringing cheer to our patients and their families. For example, the fund provided Thanksgiving turkeys to many of our patients and their families last November. Also, one of our physicians, Dr. Cesar Rodriguez, used funds raised by the 2013 Spike It to Cancer to give picnic baskets to 26 patients on Easter morning.”

For additional details, contact Neumann at 502-562-4642.

Promising early preclinical research currently underway at the University of Louisville could lead to the elimination of a second surgery now commonly needed after retinal surgery.

Shlomit Schaal, M.D., Ph.D., associate professor, Department of Ophthalmology and Visual Sciences, and director of Retina, the Retina Fellowship Program in Vitreo-Retinal Diseases and Surgery and the Diabetic Retinopathy Service, Kentucky Lions Eye Center, is working with Martin O’Toole, Ph.D., assistant professor, Department of Bioengineering, on the project which is funded by the Coulter Translational Research Partnership at UofL.

The two are studying a new way for patients undergoing retinal surgery – known as “vitrectomy” – to avoid the need to have subsequent surgery to remove cataracts that develop. During vitrectomy surgery, vitreous gel is removed from the eye; it is this gel that protects the natural crystalline lens from damage caused by free radicals of oxygen.

With the gel loss during surgery, free radicals are diffused onto the lens and cause cataracts, and almost all patients undergoing vitrectomy surgery then are forced to undergo a second surgery to remove the cataracts.

Schaal and O’Toole have developed an artificial gel that is biocompatible to the vitreous gel present in the eye. Using animal models, Schaal has successfully used the biocompatible gel to create an oxygen barrier next to the lens during retinal vitrectomy surgery.

“The biocompatible gel appears to be working as well as the eye’s natural vitreous gel in blocking oxygen damage to the natural lens,” Schaal said.

The team hopes to be able to move the research into clinical trials within the next year. “The funding we’ve received from the UofL-Coulter Partnership has been invaluable in enabling us to prove our concept thus far,” Schaal said. “We are excited at the prospect of one day being able to help patients avoid the burden of cataract surgery after retinal surgery.”

The five-year, $5 million Coulter Translational Research Partnership in Bioengineering grant awarded in 2011 to UofL fosters the translation of research through successful collaboration between engineers and clinicians, supporting promising technologies.  The partnership funds promising projects in order to move innovative technologies to clinical application with the ultimate goal of accelerating the introduction of new technologies to improve the treatment and diagnosis of disease or reduce health care costs.

LOUISVILLE, Ky. – Noting the significant progress in drug and vaccine development over the past three years, the Leona M. and Harry B. Helmsley Charitable Trust, has provided a three-year, $5.5 million grant to the James Graham Brown Cancer Center at the University of Louisville to develop new treatments and vaccines for various forms of cancer.

“Seven years ago, we partnered with Owensboro Health to explore the novel idea of plant-based pharmaceuticals and vaccines in the treatment and prevention of cancer,” said Dr. James R. Ramsey, president of the University of Louisville. “Our team showed enough promise that the Helmsley Charitable Trust provided more than $3 million in research support in 2010. Today’s grant, with Dr. Donald Miller, director of the James Graham Brown Cancer Center, as the principal investigator, demonstrates the confidence the leaders of the trust have in the work that is being accomplished. We are extremely grateful to the trust for its support and we look forward to further opportunities to partner.”

The new funding will help UofL researchers move into clinical trials vaccines for cervical and colon cancer. Additionally, researchers will further develop plant-based drug delivery systems to allow for higher concentrations of anticancer drugs to be transported directly to human tumors, as well as to increase a tumor’s sensitivity to anticancer treatment. The plants involved in the research range from tobacco to soybeans to colored berries.

“The work of Dr. Miller and his team has the potential to significantly impact health around the world,” said John Codey, a trustee with the Helmsley Charitable Trust. “They are focusing on finding much less expensive methods for delivering vaccines and medications so that these treatments are accessible to even the poorest of countries. We are pleased to continue to support efforts that have the potential to relieve suffering for a significant segment of people around the world.”

The Helmsley Charitable Trust also has funded research at UofL focused on helping people with spinal cord injuries regain function. To date, the Helmsley Charitable Trust has provided UofL with nearly $15 million in research funding.

“Federal funding for research continues to be more and more competitive, with fewer researchers receiving funds each year,” said Dr. David L. Dunn, executive vice president for health affairs at UofL. “The resources the Helmsley Charitable Trust provides enables our internationally renowned researchers to continue with their groundbreaking work that has the potential to transform the lives of people worldwide. It is through these significant partnerships that innovative health care approaches are possible.”

“Owensboro Health’s cancer research partnership with the University of Louisville has allowed us to help lead the charge with groundbreaking projects in the fight against cancer. This grant has been key in allowing us to work toward taking solutions from the laboratory bench to the patient bedside,” said Philip Patterson, president and CEO of Owensboro Health. “Since its creation in 2007, the team at the Owensboro Cancer Research Program at our Mitchell Memorial Cancer Center has made tremendous strides. We are grateful for the renewed support from the Helmsley Charitable Trust.”

Under Miller’s leadership, researchers will move an oral cervical cancer vaccine from preclinical trials into pre-investigational new drug studies. These studies reduce the amount of time it takes to move a vaccine from the laboratory to use in people. The vaccine uses a specific protein (L2 minor capsid) to create a broad response to attack HPV, the virus responsible for the vast majority of cervical cancer, and should be ready to enter clinical trials by early 2015. This project is being led by Dr. Kenneth Palmer.

A second cervical cancer vaccine is being developed by two researchers who were part of the team that created the world’s first cervical cancer vaccine. Drs. Bennett Jenson and Shin-Je Ghim are working on a vaccine that is biosimilar to the original vaccine, but produced in tobacco plants. This effort also will enter into the pre-IND phase over the next two years.

Drs. Nobuyuki Matoba and Palmer are developing an oral cholera vaccine that may prove to be a way to prevent colon cancer. The gastrointestinal issues associated with cholera create a favorable environment for the development of colon cancer, thus, preventing cholera can also prevent colon cancer. The goal is for this vaccine to enter clinical trials in late 2014.

For several years, Dr. Huang-Ge Zhang has been exploring the anticancer properties of tiny particles called plant exosomes. Animal studies suggest that exosomes may be able to play a role in the treatment or prevention of colon, breast and lung cancer. Zhang was the first to demonstrate that exosomes existed in plants and plans to demonstrate that they could be used to deliver higher concentrations of anticancer drugs directly to human tumors.

Dr. Ramesh Gupta has uncovered that certain compounds within colored berries increase the anticancer effect of chemotherapy drugs. This has the potential to enable smaller amounts of the drugs to be used, but with the same or more beneficial effects.

“Our goal is to cure cancer in people, not in mice,” Miller said. “The Owensboro Cancer Research Program is a tremendous tool for reaching that goal, not just locally or regionally, but worldwide. Through plant-based pharmaceuticals, we will be able to provide low-cost vaccines and anticancer medications that make them accessible to even the poorest of nations. To have an organization like the Helmsley Charitable Trust partner with us will enable us to move toward our goal at a much quicker pace.”

UofL’s comprehensive campaign is scheduled to wrap up June 30 after already surpassing its $1 billion goal. Charting our Course formally launched in 2010 with the funds raised designated for academic support, scholarships and programs for students; faculty recruitment, research and professional development; infrastructure enhancements and upkeep of athletic facilities; and support of the university's academic units and libraries. More than 75,000 donors throughout the world have invested in the future of the University of Louisville. 

About the Helmsley Charitable Trust

The Leona M. and Harry B. Helmsley Charitable Trust aspires to improve lives by supporting effective nonprofits in health, place-based initiatives, and education and human services.Since 2008, when the Trust began its active grantmaking, it has committed more than $1 billion to a wide range of charitable organizations.For more information on the Trust and its programs, visit www.helmsleytrust.org.

An institute at the University of Louisville and the physician-director of UofL’s James Graham Brown Cancer Center won two MediStar awards presented Tuesday (May 13) at the Hyatt Regency Louisville.

The Institute of Molecular Cardiology, under the leadership of Director Roberto Bolli, M.D., received the Healthcare Innovation Award and Donald Miller, M.D., Ph.D., director of the cancer center, a part of KentuckyOne Health, was named the XLerateHealth Physician of the Year.

The Healthcare Innovation Award is presented to an organization that has developed a new procedure, device, service program or treatment that improves the delivery of medical care. Under Bolli’s leadership, the Institute of Molecular Cardiology (IMC) has become recognized worldwide as a leading cardiovascular research program for its contributions in ischemic heart disease, heart failure, diabetes and obesity and adult stem cell therapy for cardiac repair and regeneration. Established in 2001, the IMC consistently brings more than $13 million annually in federal funding to the Louisville Metro region in developing novel treatments and future cures for the nation’s No. 1 killer, cardiovascular disease.

The XLerateHealth Physician of the Year Award is conferred upon a physician who has shown outstanding leadership and vision and has contributed to his or her workplace, leaving a lasting legacy. Named director of the James Graham Brown Cancer Center (JGBCC) in 1999, Miller also is the James Graham Brown Foundation Chair and Professor of Oncology and Associate Vice President for Health Affairs at UofL. Under his leadership, the JGBCC developed a nationally recognized leadership program in cancer drug development with more than two dozen novel treatments being studied and three entering early phase clinical trials. Miller’s own laboratory is currently studying short DNA sequences which are believed to cause cancer cell death; it is expected that treatments from his lab will enter clinical trials within the next two years.

Since 2007 IGE Media, publisher of Medical News and Medical News For You, has recognized excellence at the annual MediStar Awards, honoring professionals, volunteers and programs for their impact on health care. Also named finalists for MediStar Awards from UofL were:

• BOK Financial Aging Care Award: UofL Physicians-Geriatrics
• Facility Design Award: Nucleus Innovation Park Downtown and School of Dentistry and Department of Pediatrics at the Sam Swope Kosair Charities Centre
• Hall Render Leadership in Healthcare Award: Gerard Rabalais, M.D., Chair, Department of Pediatrics
• Middleton Reutlinger Nurse of the Year Award: Stephanie Jensen, R.N., Diabetes Nurse Educator, UofL Physicians-Pediatric Endocrinology
• Seven Counties Services Healthcare Advocacy Award: Stephen Wright, M.D., Professor, Department of Pediatrics
• A.O. Sullivan Award for Excellence in Education: Department of Pediatrics Medical Education Program
• XLerateHealth Physician of the Year Award: Toni Ganzel, M.D., Dean, School of Medicine

Cardiovascular disease is the leading cause of death among women, striking one in three. About every 60 seconds, a woman dies from heart disease.

With this as a backdrop, the University of Louisville School of Medicine, Department of Cardiovascular & Thoracic Surgery, in conjunction with KentuckyOne Health and University of Louisville Physicians, is hosting a one-day conference in Louisville to help educate patients and health care professionals about the prevention, recognition and treatment of the disease in women.

Heart disease is more deadly for women than all forms of cancer combined, according to the American Heart Association, and 90 percent of women have one or more risk factors, and more than one in three have some form of cardiovascular disease. Yet, women don’t recognize that heart disease is their biggest health threat.

“Although heart disease is a multi-factored, complex disorder, it is preventable, but education about the disease in women is essential,” said Kendra Grubb, M.D., assistant professor of cardiovascular and thoracic surgery at UofL.

To help in this educational effort, Grubb has organized the 2014 Louisville Symposium on Heart Disease in Women, the first of what is planned to be an annual event.

The conference will be held Saturday, June 28, at the Jewish Hospital Rudd Heart & Lung Center, 16th Floor Conference Center, 201 Abraham Flexner Way in Louisville. It is designed to provide physicians, nurses, allied health professional and the community with up-to-date information pertaining to the prevention and treatment of cardiovascular disease in women.

Two dozen doctors and health professionals are scheduled to speak including Toni Ganzel, M.D., dean of the UofL School of Medicine, and Ruth Brinkley, CEO of KentuckyOne Health.

The conference begins at 7 a.m. with registration and a continental breakfast, with the program starting at 8 a.m. The event ends at 5 p.m., with a reception to follow.

Continuing medical education (CME) credit is available. For more information on CME credit, click http://www.louisvilleheartdiseasewomen.com/about.html.

To see the agenda, click http://www.louisvilleheartdiseasewomen.com/agenda.html.

All are welcome at the conference, but registration is required. Costs are:

• Physicians: $100
• Allied health professionals/nurses: $50
• Community: $25
• Students/residents/fellows: Free with registration before June 2

To register, click http://www.louisvilleheartdiseasewomen.com/registration-contact.html.

For more about the conference, go to http://www.louisvilleheartdiseasewomen.com/home.html or call 502-561-2180.

Researchers at the University of Louisville are launching a clinical research study to develop an objective approach to discharge patients with heart failure from the hospital with the goal of decreasing their possible readmission.

Saeed A. Jortani, Ph.D., clinical associate professor of pathology and laboratory medicine, will lead a team of investigators including cardiologists, emergency medicine physicians, nurses and clinical coordinators in the “Congestive Heart Failure Readmission (CHFR) Trial.” It is now open for enrollment.

The team’s goal is to enroll 600 patients with symptoms of congestive heart failure who are admitted to the emergency departments at two KentuckyOne Health hospitals, University of Louisville Hospital and Jewish Hospital. Blood samples will be collected from patients at the time they are admitted and again when they are discharged. These samples will be analyzed for a variety of cardiac and kidney biomarkers.

The patients then will be surveyed twice, at 30 days and 6 months after discharge, to learn if their condition required readmission to the hospital.

The team will use the data obtained from the blood samples to develop an evidence-based approach that could be used in determining the optimal timing for discharging patients with heart failure and ultimately prevent readmission.

“We believe that using an objective, clinically verified approach to discharging heart failure patients initially could reduce the need for future readmission,” Jortani said. “Our thinking is that patients’ biomarkers will indicate when they are ready for discharge from the hospital with hopefully less chance of being readmitted later on.”

According to the Centers for Disease Control and Prevention, heart failure affects about 5 million people in the United States, with 550,000 new patients diagnosed each year. Patients with heart failure also have a high incidence of other life-threatening diseases and conditions, such as renal failure, hypertension, diabetes and others.

Each year, more than 1 million people are admitted to an inpatient facility for heart failure, and 27 percent of patients with heart failure who are on Medicare are readmitted within 30 days.

New guidelines established by the Affordable Care Act limits put limits on readmitting patients within a 30-day time period for the same diagnosis.

“Finding the right ‘formula’ for discharge and reducing readmission rates will help us improve the ultimate health outcome for the patient as well as realize significant cost savings in the long run,” Jortani said.

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About the CHFR Trial:

Principal investigator of the CHFR Trial is Saeed Jortani. The research team includes cardiologists Andrew DeFilippis, Shahab Ghafghazi and Jesse Adams; emergency medicine physicians George Bosse, Salvator Vicario and Tadd Roberts; nurses Ashlee Melendez, Kristen Young and Cynthia Lawrence; clinical coordinators Stanislava Prather, Anna Mains, Keivan Hosseinnegad and Louise Isaacs; and biostatistician Richard Baumgartner. Blood sample analysis will be conducted at the Kentucky Clinical Trials Laboratory. The study is funded in part by Roche Diagnostics USA. For information about the trial, contact 502-852-8835 or sjortani@louisville.edu.

Darrell A. Griffith has been named the new associate vice president for health affairs/finance and administration for the University of Louisville Health Sciences Center. He also will assume the position of vice president/CFO for University of Louisville Physicians. Griffith comes from the University of Kentucky/UK Healthcare, where he was the executive director for the faculty practice organization.

David L. Dunn, M.D., Ph.D., UofL executive vice president for health affairs, highlighted Griffith’s extensive financial experience within academic medicine and physician practices.

“I am very pleased to welcome Darrell to the UofL Health Sciences Center,” Dunn said. “He understands the complexity of an academic health center and the role of the faculty practice plan. His experience is critical as we begin the next steps in the transformation of the health sciences center.”

Griffith has spent the past 11 years at the University of Kentucky, initially as a senior manager of business development and decision support. He served two years as the interim associate dean for administration and finance for the College of Medicine before taking his current role in 2006. He was instrumental in developing the UK Healthcare strategic plan that saw unprecedented growth in revenues and outpatient care.

Prior to joining UK, Griffith was a senior consultant with Avalon Management Consulting LLC, in Knoxville, Tenn. He also has been with Promina-Dekalb Regional Healthcare System in Atlanta, Erlanger Health System in Chattanooga, Tenn., and Healthcare Resources Inc. in Somerset, Ky.

Griffith earned his bachelor of science in business administration and his master of public health/health care administration from the University of Tennessee. He is a certified medical practice executive from the American College of Medical Practice Executives. He is a member of the Academic Practice Plan Directors under the University Health Consortium.

The singer-songwriter of 2007’s country hit “Stealing Cinderella” and the currently-rising-up-the-charts “Us Again,” Chuck Wicks, will walk the red carpet at The Julep Ball.

The premier Derby Eve Party with a Purpose, The Julep Ball is held annually on the evening before the Kentucky Derby and supports the work of the James Graham Brown Cancer Center at the University of Louisville. The event on May 2 at the KFC Yum! Center kicks off with a 6:30 p.m. cocktail reception, followed by dinner and a live auction at 8 p.m.

An Official Event of the 140^th Kentucky Derby®, The Julep Ball provides a celebrity-studded night to remember with a multi-course seated dinner, a knock-your-socks-off auction, multiple open specialty bars, complimentary valet parking, and dancing until the wee hours of Derby morning. Tickets for the full evening of entertainment are sold out but a limited number of dance-only tickets at $100 per person are still available. For further information and to buy tickets, go to The Julep Ball website, julepball.org.

About Chuck Wicks:

On his new single that is rising the charts, “Us Again,” Chuck Wicks is clearly in the zone. The story of a couple who long to return to a time when loving each other was easy, the song also marks the return to the country charts for the Delaware farm boy.

“It’s a unique love song,” says Wicks, who co-wrote the hit with Andy Dodd and Tiffany Vartanyan. “It’s one of those things we all go through. When you first meet that someone who is really special, the first three to four months are flawless. Every day is a honeymoon. But as time goes on and life starts to happen, you can forget what it’s like and lose that spark.”

Now signed to Blaster Records, Wicks, who moonlights as a morning personality on NASH-FM’s popular America’s Morning Show (“I love speaking the language of country music and this gives me the chance to do that every day,” he says), has discovered his own creative fire.

After the breakout success of his 2007 debut single “Stealing Cinderella,” which hit the Top 5 on the Billboard country chart and marked the biggest single for any new country artist in 2007, the pristine-voiced singer actively took a step back and committed himself to songwriting. Freshly inspired, he’s readying his latest album, the follow-up to 2008’s Starting Now, which peaked at No. 7 on the Billboard country albums chart.

“I’m a lot more comfortable with who I am,” he says. “I feel like I’ve figured out who I am as a songwriter, as a singer, as an artist. I know where my pocket is.”

The upcoming album, co-produced by Chuck, will include all of the tracks from his EP Rough, a recent collection of songs that showcased Chuck’s lived-in sound.

“From Starting Now to today, I’ve grown so much as a writer and a performer,” says Wicks, who has performed in every state in the continental United States. “Releasing your first single on a major label is a lot to navigate, especially if you’ve never done it. I got thrown out on a huge tour with Brad Paisley and went from playing conference rooms with two guitar players to playing Denver, Colorado, my first big show in an arena.

“Grow up, have a family and work 9 to 5: That’s what most everybody sees in their future,” Wicks says. “I feel so lucky to do something different and special.”

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About the James Graham Brown Cancer Center:

The James Graham Brown Cancer Center is a key component of the University of Louisville Health Sciences Center. As part of the region's leading academic, research and teaching health center, the cancer center provides the latest medical advances to patients, often long before they become available in non-teaching settings. The JGBCC is a part of KentuckyOne Health and is affiliated with the Kentucky Cancer Program. It is the only cancer center in the region to use a unified approach to cancer care, with multidisciplinary teams of physicians working together to guide patients through diagnosis, treatment and recovery. For more information, visit our web site, www.browncancercenter.org.

The Julep Ball is sponsored in part by Advanced Cancer Therapeutics, Ashton Advertising, Bob Montgomery Dixie Honda, Boutique Serendipity, The Dahlem Company, Dillards, Enterprise, Headz Salon, Heaven Hill, Hubbuch & Co., InGrid Design, Jaust Consulting Partners, Jefferson County Sheriff’s Office, KentuckyOne Health, Kroger, Louisville Magazine, Maker’s Mark, Millennium: The Takeda Oncology Company, Morgan Stanley, MPI Printing, Nfocus, Old 502 Winery, Power Creative, Tito’s Handmade Vodka, WAKY and WHAS11.

Five of University of Louisville Head Coach Rick Pitino’s key assistants will walk the red carpet at The Julep Ball.

Mike Balado, Kenny Johnson, Wyking Jones,Kevin Keatts and David Padgett will be among the stars from the sports and entertainment worlds at the May 2 gala.

The premier Derby Eve Party with a Purpose, The Julep Ball is held annually on the evening before the Kentucky Derby and supports the work of the James Graham Brown Cancer Center at the University of Louisville. The event on May 2 at the KFC Yum! Center kicks off with a 6:30 p.m. cocktail reception, followed by dinner and a live auction at 8 p.m.

An Official Event of the 140^th Kentucky Derby®, The Julep Ball provides a celebrity-studded night to remember with a multi-course seated dinner, a knock-your-socks-off auction, multiple open specialty bars, complimentary valet parking, and dancing until the wee hours of Derby morning. A limited number of tickets to The Julep Ball are still available. The full evening’s entertainment is $600 per person, $5,000 for a table of 10, and $100 per person for dance-only tickets. For further information and to buy tickets, go to The Julep Ball website, julepball.org.

About Balado, Johnson, Jones, Keatts and Padgett:

Mike Balado (pronounced bah-LAW-doe) joined the University of Louisville men's basketball staff as an assistant coach in April 2013 after serving in a similar capacity at Florida International from 2012-13.

Balado helped FIU to quickly achieve success when the 18-14 Panthers produced their first winning season in 13 years, the fourth-highest win total in school history and the most Sun Belt Conference victories (11) since joining the league in 1998-99. He was an assistant under Richard Pitino, the son of UofL head coach Rick Pitino, who is now the head coach at Minnesota.

"Mike brings a wealth of experience in both the recruiting world and in coaching," said Pitino. "An important factor in adding him to our staff was his knowledge of what we do defensively and in scouting, after working with Richard (Pitino) for a year. It should not take a great deal of time in acclimating him to our program. He's a tireless worker and he should fit like a glove. He also brings another facet to our recruiting efforts, as he speaks fluent Spanish and has connections throughout Latin America."

Prior to his year at FIU, Balado worked three seasons at High Point University (2009-12), where he assisted in all areas of the Panther basketball program with a heavy concentration on recruiting. He spent the 2008-09 season on the Miami (Fla.) basketball staff where he helped the Hurricanes compile a 19-13 record and a berth in the National Invitation Tournament (NIT) while working on player development, scouting and game preparation.

Balado played collegiate basketball at St. Thomas University in Miami, where he was a two-year starter and captain while helping his team win the regular season conference title in 1997. Recipient of a student-athlete leadership award as a senior, he earned a bachelor's degree in psychology from St. Thomas in 1998 and a master's of education in exercise and sport science from Augusta State in 2000. A native of Miami, Fla.,

Balado is married to the former Alicia Nigro and the couple had twins, Aiden and Addy, in June 2009.

Kenny Johnson, assistant men's basketball coach and recruiting coordinator at Indiana for the past two years, joined the Louisville men's basketball staff as an assistant coach under head coach Rick Pitino in April 2014.

"We're very excited to have Kenny in our program," said Pitino. "The first thing I did when Kevin Keatts left to become the head coach at UNC Wilmington was to ask my son Richard (Pitino, head coach at Minnesota) to find the best rising assistant coach in the business. He spoke to a lot of people and they led directly to Kenny Johnson and others think he is outstanding as well. He is extremely bright, having studied cell, molecular biology and genetics in college."

While at Indiana, Johnson helped the Hoosiers assemble top 20 recruiting classes each of the past two seasons. On the court, Indiana produced a combined 46-22 record in his two seasons there, winning the Big Ten Championship, earning a No. 1 seed in the NCAA Tournament and reaching the NCAA Sweet 16 in 2013.

ESPN.com's Jeff Goodman, after surveying more than 200 collegiate coaches, named Johnson as the nation's 11th most respected/feared assistant coach in a July 2013 listing after just two seasons as a collegiate assistant.

Johnson was an assistant coach at Towson in 2011-12, helping assemble a top five mid-major recruiting class. He began his coaching career in 2002 as the associate head coach at Eleanor Roosevelt High School before moving to Dr. Henry Wise High School in 2006 for one year. He was associate head coach at Paul IV High school for four years (2007-11) before advancing to the collegiate ranks.

As a senior at Oxon Hill (Md.) High School in 1994, he was named Science and Technology Student of the Year. He earned his bachelor's degree in cell, molecular biology and genetics in 1999 at the University of Maryland, where he was a Benjamin Banneker Scholarship recipient. He worked as a protein chemist/molecular biologist at Human Genome Sciences in Rockville, Md. after graduation.

A native of Oxon Hill, Johnson and his wife, Doreen, have two sons, Amare (11) and Mekai (8).

Wyking Jones (pronounced WHY-king) is in his third season as an assistant basketball coach for the University of Louisville after serving in a similar capacity two seasons at the University of New Mexico. He joined the Cardinals in April 2011.

"Wyking has the experience necessary to help us recruit top-notch student-athletes from all 50 states," said Pitino. "He is highly regarded in all circles as a tireless worker and an outstanding communicator with young people. I had asked Richard (Pitino) to provide me the top five assistant coaching candidates in the country and I would interview them. Immediately he had Wyking at the top of the list. After considerable research, it was apparent that he had all of the characteristics necessary to bring to Cardinal Basketball."

In Jones' two seasons, the Cardinals reached the NCAA Final Four twice - including winning the 2013 NCAA Championship -- and have a combined 65-15 record. He has helped the Cardinals assemble two straight top 10 recruiting classes.

During Jones' two years at New Mexico under head coach Steve Alford, the Lobos produced a combined 52-18 record. The 2009-10 New Mexico team won a school-record 30 games (30-5 record), won the Mountain West Conference Championship and was ranked eighth in the final AP poll.

Before joining the New Mexico staff, Jones spent two years as a basketball travel team manager with Nike Elite Youth Basketball. There he managed all 45 travel teams and the tournaments that Nike sponsored in its grassroots youth program while he built key relationships across the nation.

Jones lettered four years at Loyola Marymount for head coach John Olive (1991-95). He emerged as a junior through a staunch work ethic and unassuming manner to earn all-West Coast Conference honors and the Lions’ Student Athlete of the Year in 1993-94.

Jones earned a bachelor's degree in business administration from Loyola Marymount in 1995. He served as a Lions' assistant coach during the 1996-97 season. He and his wife, Estrella, have a son, Jameel, and a daughter, Zoe.

Kevin Keatts, who won two national prep championships and was runner-up on three occasions as head coach at Hargrave Military Academy over eight seasons, just wrapped up his final year on the University of Louisville men's basketball staff.

In March, Keatts was named head coach at University of North Carolina-Wilmington, joining 10 other former assistants under Pitino now serving as college head coaches.

"Kevin has been one of the best assistant coaches with which I have had the good fortune to work, and I've had a lot of them," Pitino said. "He is a terrific person, coach, scout, family man and recruiter. He possesses all of the variables to build a successful program. We are really going to miss his upbeat personality … ."

Keatts was promoted to associate head coach in January 2014 after serving as an assistant coach under head coach Rick Pitino since joining the Cardinals in April 2011 and helped the Cardinals assemble two straight top ten recruiting classes. In his two seasons at UofL, the Cardinals reached the NCAA Final Four twice -- including winning the 2013 NCAA Championship -- won two Big East Conference championships, and have a combined 65-15 record.

ESPN.com's Jeff Goodman, after surveying more than 200 collegiate coaches, named Keatts as the nation's third most respected/feared assistant coach in a July 2013 listing.

Keatts' success as a prep coach is staggering. In 10 seasons in two separate stints as the head coach at Hargrave (1999-2001, 2003-2011), he compiled an incredible 263-17 record with two national prep titles (2004, 2008), three runner-up finishes (2005, 2006, 2009) and two additional appearances among the final four prep teams (2007, 2010).

Keatts coached nine players at the prep level that reached the NBA: Joe Alexander, Jordan Crawford, Josh Howard, Vernon Macklin, Mike Scott, Marreese Speights, Sam Young, David West and Korleone Young.

Keatts was a two sport standout in basketball and football at Heritage High School in Lynchburg, Va., and also excelled in basketball at Ferrum College. He and his wife Georgette have two sons, Kevin (9) and Kaden (5).

David Padgett, a former three-year starting center for the Cardinals, is in his first year on the UofL men’s basketball staff as assistant video coordinator.

Padgett spent three years as an assistant basketball coach at IUPUI (2011-14) after a year with UofL as an assistant strength coach (2010-11). He played professional basketball for UB LaPalma in the Canary Islands for two years following his graduation from UofL. He had reached the final preseason cut of the Miami Heat before his playing career in Spain.

A three-year starter and captain at center for the Cards (2005-08), Padgett was a unanimous first-team All-BIG EAST Conference selection as a senior and also earned USBWA All-District IV honors.  He averaged a team-leading 11.2 points and grabbed 4.8 rebounds his senior year in 2007-08 when the Cardinals reached the NCAA Elite Eight.

Padgett ranks second in career field goal percentage at UofL, hitting 61.3 percent of his shots (332-542). His .667 field goal percentage as a senior was the second best ever at UofL. He set a BIG EAST Conference field goal percentage record for league games as a senior, hitting 68.3 percent of his shots in 18 games (86-of-126). He was a second team All-BIG EAST pick as a junior.

Padgett’s basketball bloodlines run deep as his father played at the University of Nevada and his uncle played at New Mexico. His grandfather Jim played for Oregon State and his sister played for the University of San Diego.

Padgett and his wife, Megan, welcomed their first child Nolan in August 2013.

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About the James Graham Brown Cancer Center:

The James Graham Brown Cancer Center is a key component of the University of Louisville Health Sciences Center. As part of the region's leading academic, research and teaching health center, the cancer center provides the latest medical advances to patients, often long before they become available in non-teaching settings. The JGBCC is a part of KentuckyOne Health and is affiliated with the Kentucky Cancer Program. It is the only cancer center in the region to use a unified approach to cancer care, with multidisciplinary teams of physicians working together to guide patients through diagnosis, treatment and recovery. For more information, visit our web site, www.browncancercenter.org.

The Julep Ball is sponsored in part by Advanced Cancer Therapeutics, Ashton Advertising, Bob Montgomery Dixie Honda, Boutique Serendipity, The Dahlem Company, Dillards, Enterprise, Headz Salon, Heaven Hill, Hubbuch & Co., InGrid Design, Jaust Consulting Partners, Jefferson County Sheriff’s Office, KentuckyOne Health, Kroger, Louisville Magazine, Maker’s Mark, Millennium: The Takeda Oncology Company, Morgan Stanley, MPI Printing, Nfocus, Old 502 Winery, Power Creative, Tito’s Handmade Vodka, WAKY and WHAS11.

Two of the hottest acts making names for themselves in country music have just been added to the lineup of performers at The Julep Ball.

The duo Brothers Osborne, who recently dropped their latest single “Rum,”and Hart of Dixie and Anger Management star Laura Bell Bundy, whose country single “Giddy On Up” garnered over 4 million streams, will join J.D. Shelburne and the Bob Hardwick Sound on The Julep Ball stage.

The premier Derby Eve Party with a Purpose, The Julep Ball is held annually on the evening before the Kentucky Derby and supports the work of the James Graham Brown Cancer Center at the University of Louisville. The event on May 2 at the KFC Yum! Center kicks off with a 6:30 p.m. cocktail reception, followed by dinner and a live auction at 8 p.m.

An Official Event of the 140^th Kentucky Derby®, The Julep Ball provides a celebrity-studded night to remember with a multi-course seated dinner, a knock-your-socks-off auction, multiple open specialty bars, complimentary valet parking, and dancing until the wee hours of Derby morning. A limited number of tickets to The Julep Ball are still available. The full evening’s entertainment is $600 per person, $5,000 for a table of 10, and $100 per person for dance-only tickets. For further information and to buy tickets, go to The Julep Ball website, julepball.org.

About Brothers Osborne:

One of 15 acts chosen by Country Weeklyas “Ones to Watch in 2014,” Brothers Osborne were chosen this month to open for Eric Church in his upcoming tour that includes a stop in Louisville at the KFC Yum! Center on Sept. 25.

The current Rolling Stone(April 24) hails the duo’s current single “Rum”: “There are plenty of drinking songs coming out of Nashville these days, but this twangy party anthem by a rising sibling duo from Maryland takes the genre to a whole new level of catchy fun. Sounds like a hit to us!”

For John and TJ Osborne, getting into music was unavoidable. Growing up in the water town of Deale, Md., their close-knit-family of seven spent most nights not in front of the television, but writing and playing songs.

John (guitar) moved to Nashville first to play in other bands before TJ (vocals/guitar) joined him. It was then they formed Brothers Osborne and began playing as many writer rounds as they could. In April 2011, Warner Chappell/King Pen Music offered them a publishing deal. A year later, Capitol Records offered them a record deal. The Brothers Osborne are currently in the studio finishing their debut album, an album they describe as “aggressive, bold and fragile at times.” For more information, visit www.brothersosborne.com.

About Laura Bell Bundy:

A Kentucky native, Laura Bell Bundy is a performer who has done it all: from appearing on the Broadway stage as Elle Woods in Legally Blonde – a role that garnered her a Tony Award nomination – Glinda in Wicked, and Amber Von Tussle in the original cast of Hairspray, to the launch of her country music career with a captivating performance on the nationally televised Academy of Country Music Awards, to acting in various film and TV roles including Dreamgirls, Jumanji, The Adventures of Huck Finn, MTV’s smash telecast of Legally Blonde, Guiding Light, CBS’s How I Met Your Mother, Malibu Country, Home Improvement and Cold Case. Bundy’s screen success has followed her to the web, where she has attracted a worldwide audience with her hit comedic web series, Cooter County, which she created, produced and directed.

Bundy released her debut country music album, Achin’ and Shakin’, in 2010, featuring her hit single “Giddy On Up,” which has since garnered over 4 million streams and has been certified gold in Norway. Her most recent singles, “Two Step” and “Kentucky Dirty,” push music boundaries and answer the question of what happens when you combine hot country, dance tracks and hip-hop beats.

Bundy currently can be seen on the CW’s hit television program Hart of Dixie and FX’s Anger Management, both of which are aired throughout the world. Her latest song release, “Kentucky Dirty” hit iTunes in November of 2013. The track references the singer’s good ole Kentucky roots. For more information, visit www.laurabellbundy.com.

About the James Graham Brown Cancer Center:

The James Graham Brown Cancer Center is a key component of the University of Louisville Health Sciences Center. As part of the region's leading academic, research and teaching health center, the cancer center provides the latest medical advances to patients, often long before they become available in non-teaching settings. The JGBCC is a part of KentuckyOne Health and is affiliated with the Kentucky Cancer Program. It is the only cancer center in the region to use a unified approach to cancer care, with multidisciplinary teams of physicians working together to guide patients through diagnosis, treatment and recovery. For more information, visit our web site, www.browncancercenter.org.

The Julep Ball is sponsored in part by Advanced Cancer Therapeutics, Ashton Advertising, Bob Montgomery Dixie Honda, Boutique Serendipity, The Dahlem Company, Dillards, Enterprise, Headz Salon, Heaven Hill, Hubbuch & Co., InGrid Design, Jaust Consulting Partners, Jefferson County Sheriff’s Office, KentuckyOne Health, Kroger, Louisville Magazine, Maker’s Mark, Millennium: The Takeda Oncology Company, Morgan Stanley, MPI Printing, Nfocus, Old 502 Winery, Power Creative, Tito’s Handmade Vodka, WAKY and WHAS11.

Jeff Walz, head coach of the University of Louisville women’s basketball team, will walk the red carpet at The Julep Ball.

The premier Derby Eve Party with a Purpose, The Julep Ball is held annually on the evening before the Kentucky Derby and supports the work of the James Graham Brown Cancer Center at the University of Louisville. The event on May 2 at the KFC Yum! Center kicks off with a 6:30 p.m. cocktail reception, followed by dinner and a live auction at 8 p.m.

An Official Event of the 140^th Kentucky Derby®, The Julep Ball provides a celebrity-studded night to remember with a multi-course seated dinner, a knock-your-socks-off auction, multiple open specialty bars, complimentary valet parking, and dancing until the wee hours of Derby morning. Tickets to The Julep Ball sell out early each year. The full evening’s entertainment is $600 per person, $5,000 for a table of 10, and $100 per person for dance-only tickets. For further information and to buy tickets, go to The Julep Ball website, julepball.org.

About Jeff Walz

Considered by many to be the best young coach in women's basketball, Jeff Walz has made a career out of building successful programs. Walz has lived up to that reputation since taking over the helm at Louisville, taking the program to new heights. In his first six seasons, he has guided the Cardinals to two Final Four appearances and National Runner-up finishes in 2009 and 2013 along with four Sweet 16 appearances.

Walz's success can be traced back to recruiting. He is known as a tireless recruiter and has not let up since becoming a head coach. In just his first season, Walz and his staff brought in the highest ranked recruiting class in Cardinal history. He has since followed it up with three consecutive Top 10 classes, with the 2010 class ranked fifth in the nation. The 2011 class made school history with two McDonald's All-Americans.

He was named the sixth head coach at the University Louisville on March 27, 2007. Walz, a Kentucky native, returned to the bluegrass state after serving as an associate head coach at Maryland.

In the 2012-2013 season, Walz led the Cardinals to the biggest upset in women's basketball history by defeating the No. 1 overall seed Baylor in the Sweet 16 of the NCAA Tournament. The Cardinals went on to defeat the No. 2 seeded Tennessee Lady Vols in the Elite Eight to reach their second Final Four appearance in four years.

Louisville went on to defeat No. 2 seed California in the national semifinal, advancing to the National Championship for the second time in Walz's career as a head coach. Entering the NCAA Tournament the Cardinals were ranked No. 16 but finished the year ranked third with a 29-9 overall record and another miraculous run in the NCAA Tournament.

During the 2012 season Walz had his most talented team in four seasons but lost two of his top three scorers early in the season. Despite the adversity, Walz led the team to a 23-10 record. The Cardinals advanced to the second round of the NCAA Tournament and ended the season with a final ranking of 16th in the nation.

Walz began his coaching career at the middle and high school levels in 1992 and was an AAU coach in 1995-96. During his career, he has guided such players as 1996 National High School Player of the Year Jaime Walz, his sister, who now coaches the girls' high school team at their alma mater, Highlands High School. He also coached 1999 NCAA champion and WNBA standout Ukari Figgs, the University of Tennessee's Kyra Elzy, and Ohio State standout Louisville native, Marita Porter.

He attended Northern Kentucky University on a basketball scholarship, graduating with a bachelor of science in secondary education in May 1995. Walz earned his master's in education in August of 1997 from Western Kentucky.

Walz has three children, daughter Kaeley, son Jacob, and daughter Lola. He married to the former Lauren Lueders and the couple reside in Louisville.

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About the James Graham Brown Cancer Center:

The James Graham Brown Cancer Center is a key component of the University of Louisville Health Sciences Center. As part of the region's leading academic, research and teaching health center, the cancer center provides the latest medical advances to patients, often long before they become available in non-teaching settings. The JGBCC is a part of KentuckyOne Health and is affiliated with the Kentucky Cancer Program. It is the only cancer center in the region to use a unified approach to cancer care, with multidisciplinary teams of physicians working together to guide patients through diagnosis, treatment and recovery. For more information, visit our web site, www.browncancercenter.org.

The Julep Ball is sponsored in part by Advanced Cancer Therapeutics, Ashton Advertising, Bob Montgomery Dixie Honda, Boutique Serendipity, The Dahlem Company, Dillards, Enterprise, Headz Salon, Heaven Hill, Hubbuch & Co., InGrid Design, Jaust Consulting Partners, Jefferson County Sheriff’s Office, KentuckyOne Health, Kroger, Louisville Magazine, Maker’s Mark, Millennium: The Takeda Oncology Company, Morgan Stanley, MPI Printing, Nfocus, Old 502 Winery, Power Creative, Tito’s Handmade Vodka, WAKY and WHAS11.

Four of the NFL’s finest will join University of Louisville Head Football Coach Bobby Petrinoon the red carpet at The Julep Ball.

The premier Derby Eve Party with a Purpose, The Julep Ball is held annually on the evening before the Kentucky Derby and supports the work of the James Graham Brown Cancer Center at the University of Louisville. The event on May 2 at the KFC Yum! Center kicks off with a 6:30 p.m. cocktail reception, followed by dinner and a live auction at 8 p.m.

An Official Event of the 140^th Kentucky Derby®, The Julep Ball provides a celebrity-studded night to remember with a multi-course seated dinner, a knock-your-socks-off auction, multiple open specialty bars, complimentary valet parking, and dancing until the wee hours of Derby morning. Tickets to The Julep Ball sell out early each year. The full evening’s entertainment is $600 per person, $5,000 for a table of 10, and $100 per person for dance-only tickets. For further information and to buy tickets, go to The Julep Ball website, julepball.org.

Two former UofL Cardinals now in the NFL – Eric Wood and Joe Johnson – will join EJ Manuel and Kyle Rudolph at The Julep Ball:

Joe Johnson

Joe Johnson attended the University of Louisville for four years where he was a full time starter for three years and was honored as a first team “All American” in his last year as a Cardinal.  He chose to forgo his senior year in college and was drafted 13^th overall in the 1994 NFL draft by the New Orleans Saints. Joe received a number of honors during his 10-year NFL career, including: Pro Bowl (1998 and 2000), All Madden Team (1998 and 2000), Comeback Player of the Year (2000) and All Rookie Team (1994). He was named to the New Orleans Saints Hall Of Fame in 2007.

EJ Manuel

EJ Manuel is the starting quarterback for the Buffalo Bills. He was the 16^th overall pick in the 2013 NFL Draft out of Florida State University, where he led the Seminoles to their first 12-win season since the 1990’s.  He was named the MVP of the Gator Bowl in 2009 and the MVP of the Senior Bowl in 2013. Off the field, EJ is National Ambassador for Camp Kesem, an organization dedicated to helping children whose parents suffer from cancer and is an advocate for Breast Cancer Awareness and Research in honor of his mother who is a breast cancer survivor

Kyle Rudolph

Kyle Rudolph is a tight end in his fourth season with the Minnesota Vikings. A graduate of Notre Dame and the first tight end to start every game as a freshman, Kyle was the first tight end drafted in the 2011 rookie class. After his breakout year in 2012, earning Pro Bowl MVP honors, he is now regarded as one of the league’s best. Kyle joined his teammates in community outreach activities as a rookie, planting trees as part of Planet Purple Week and visiting University of Minnesota Amplatz Children’s Hospital when the Vikings were part of the Adopt-A-Room program.

Eric Wood

Eric Wood is a University of Louisville alumnus who played for Coach Bobby Petrino at UofL and is the starting center and team captain for the Buffalo Bills. He was the team's second pick in the first round of the 2009 NFL Draft (28th overall). As a Cardinal, he earned Freshman All-American honors, All-Big East honors and Academic All-Big East accolades. Eric finished his collegiate career with 49 consecutive starts at center, the second-longest streak in school history behind Travis Leffew. Today, he is one of the five highest-paid centers in the NFL.

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About the James Graham Brown Cancer Center:

The James Graham Brown Cancer Center is a key component of the University of Louisville Health Sciences Center. As part of the region's leading academic, research and teaching health center, the cancer center provides the latest medical advances to patients, often long before they become available in non-teaching settings. The JGBCC is a part of KentuckyOne Health and is affiliated with the Kentucky Cancer Program. It is the only cancer center in the region to use a unified approach to cancer care, with multidisciplinary teams of physicians working together to guide patients through diagnosis, treatment and recovery. For more information, visit our web site, www.browncancercenter.org.

The Julep Ball is sponsored in part by Advanced Cancer Therapeutics, Ashton Advertising, Bob Montgomery Dixie Honda, Boutique Serendipity, The Dahlem Company, Dillards, Enterprise, Headz Salon, Heaven Hill, Hubbuch & Co., InGrid Design, Jaust Consulting Partners, Jefferson County Sheriff’s Office, KentuckyOne Health, Kroger, Louisville Magazine, Maker’s Mark, Millennium: The Takeda Oncology Company, Morgan Stanley, MPI Printing, Nfocus, Old 502 Winery, Power Creative, Tito’s Handmade Vodka, WAKY and WHAS11.

Some of America’s most popular reality stars will join bright talents from the world of music, television and film at the 2014 Julep Ball.

The premier Derby Eve Party with a Purpose, The Julep Ball is held annually on the evening before the Kentucky Derby and supports the work of the James Graham Brown Cancer Center at the University of Louisville. The event on May 2 at the KFC Yum! Center kicks off with a 6:30 p.m. cocktail reception, followed by dinner and a live auction at 8 p.m.

An Official Event of the 140^th Kentucky Derby®, The Julep Ball provides a celebrity-studded night to remember with a multi-course seated dinner, a knock-your-socks-off auction, multiple open specialty bars, complimentary valet parking, and dancing until the wee hours of Derby morning. Tickets to The Julep Ball sell out early each year. The full evening’s entertainment is $600 per person, $5,000 for a table of 10, and $100 per person for dance-only tickets. For further information and to buy tickets, go to The Julep Ball website, julepball.org.

This year’s celebrity guests from the world of entertainment include:

DANIELLE GREGORIO: STAR OF 'THE REAL HOUSEWIVES OF ORANGE COUNTY’

Danielle Gregorio is a wife and mother to three beautiful children, residing in Villa Park, Calif. She is the co-owner and principal designer of Danielle Kaye Design Studio, a boutique interior design firm located in Orange County, California. Interior design has always been a passion for Gregorio, so she is now able to re-create her visions in both residential and commercial design projects, living her dream of owning her own business and doing what she loves.  Gregorio also has always had a special talent and vision for planning and hosting the most amazing events. When partnering with Jimmy Choo in May 2012 to support and raise money for the Leukemia & Lymphoma Society® Man of the Year, the event was such a success that she was asked to host a yearly event. When she accepted this task, she knew it was a perfect fit to become a founding member of Heels2Heal Orange County. Most recently, Gregorio joined the seasoned cast of Bravo’s The Real Housewives of Orange County. Though new to the reality TV world, she was excited to show the world that a full-time mom, businesswoman and philanthropist can have it all.

MARK AND MATTHEW HARRIS: TASTEMAKERS ON ‘STORAGE WARS’

Mark and Matthew Harris are nationally known as starring in A&E’s hit series Storage Wars, where they are the newest bidders on the show viewed by 5 million viewers weekly.  In addition to being radio personalities in Los Angeles hosting their weekly radio show, The Tastemakers, the Harris brothers are regular judges at Miss USA pageants, including Miss California USA, Miss Illinois USA, Miss Nevada USA, Miss New Jersey USA and Miss Maryland USA. The Harris brothers are also known as “The Kings of Swag” as they own and operate the biggest celebrity marketing agency in Hollywood, WOW! CREATIONS, providing celebrity gift bags and hosting celebrity gift lounges around the world from the Cannes Film Festival, Sundance Film Festival, Oscars, Emmys, Grammys and many more events. The Harris brothers are also luxury life style consultants who have a daily blog and can be seen in upcoming Independent feature films playing wealthy investors and are currently shopping their new reality show, The Kings of Swag.

KYM JOHNSON: WINNING ‘DANCING WITH THE STARS’ FANS FROM AUSTRALIA TO THE U.S.

Aussie native Kym Johnson has made the transition from ballroom to judging panel and is currently one of four judges on Dancing with the Stars, Australia. Johnson holds three mirror-ball trophies (two in the United States and one in Australia) and she is the only professional dancer in the world to hold trophies on two different continents. In 2006, she arrived in the United States when she was asked to join the U.S. version of DWTS. Her first partner was talk show host Jerry Springer during season three, where she won the hearts of Americans. Her other partners have included some of the most popular celebrities on the show: David Hasselhoff, Joey Fatone, Jaleel White, Mark Cuban, Penn Jillette, Warren Sapp, Ingo Radamacher and David Arquette.  Johnson has been runner-up twice on the American syndicated DWTS. In November 2009, Johnson won the prestigious mirror-ball trophy with entertainer Donny Osmond, and followed up the win with another first place in 2011 with Pittsburgh Steeler Hines Ward. Johnson has been involved in 13 seasons of DWTS U.S.A.

CARSON KRESSLEY: EMMY WINNER, STYLE MAKER, FAN FAVORITE

Carson Kressley was most recently a “fan-favorite” on ABC’s world-wide hit, Dancing With The Stars and recently headlined as the host of Dancing With The Stars Live in Las Vegas. In 2011, Kressley starred in Carson-Nation, a one-hour reality show that premiered on OWN, The Oprah Winfrey Network. In Carson-Nation, he travelled to small towns throughout the United States, transforming lives one person at a time with his signature heart, humor and style. Previously, Kressley helmed Lifetime's critically acclaimed show How To Look Good Naked and earned a primetime Emmy for his role on Bravo's breakout hit series Queer Eye for the Straight Guy. He was a frequent style contributor on The Oprah Winfrey Show where millions of viewers accessed his expertise, style, and wit. He can also be seen as a style contributor on ABC’s Good Morning America,Live With Kelly and Michael!, The Queen Latifah Show, Bethenny and The Wendy Williams Show. Kressley recently debuted his signature line of women’s sportswear and accessories, "Love, Carson," which is known for its easy, instant, affordable glamour and is available exclusively at ShopHQ.

KEITH ROBINSON: KENTUCKY BRED, OSCAR NOMINATED

Before he made his way to Tinseltown, the Kentucky native set his sights on music and attended the University of Georgia. Shortly after traveling to Los Angeles and upon a chance meeting with a film and television manager, Robinson jump-started his career performing in more than 50 television and film projects and still counting while still pursuing his music career. Robinson is best known for his role as C.C. White in the Academy Award-winning film Dreamgirls, which earned him an Oscar nomination for best song that he performed at the Academy Awards. He can also be seen in such films as Dear John, Fat Albert, 35 & Ticking, This Christmas, CRU (August 2014) and the soon-to-be released James Brown biopic, Get on Up due out Aug. 1. `Robinson also is slated to release brand-new music later this year.

ELIZABETH (LIZZIE) ROVSEK: KENTUCKIAN STAR OF ‘REAL HOUSEWIVES OF ORANGE COUNTY’

Elizabeth (Lizzie) Rovsek is a swimsuit designer and stay-at-home mother of two. Lizzie is the newest Housewife on Bravo's The Real Housewives of Orange County and joined the cast in its ninth season. Elizabeth hails from the Bluegrass state, is a former Miss Kentucky USA, and is now owner and designer of her own swimsuit company, Sun Kitten Swimwear. She’s married to Christian, CEO of Service First Restoration, an emergency service construction company handling properties damaged by flood, fire, mold and more, and they have two children, 3-year-old Preston and 2-year-old Kingston. They live in Orange County, California, and plan on growing their family in 2015.

JON SEDA: CURRENTLY HEATING UP  ‘CHICAGO PD’

His television credits include series regular roles on Kevin Hill and Close to Home and recurring roles in Ghost Whisperer and Oz. Seda also guest starred on Hawaii Five-0, The Closer, Burn Notice, House, M.D, CSI: Miami, NYPD Blue, Las Vegas and Law and Order, among many others. In 2010, Seda was seen in the award-winning HBO World War II miniseries The Pacific, playing the starring role of legendary marine Jon Basilone, and joined the cast of the acclaimed HBO series Treme as a series regular. Seda can currently be seen starring as Detective Antonio Dawson on Chicago PD. The show, created by Emmy Award-winning executive producer Dick Wolf, is a spin-off of Chicago Fire and airs on NBC.

MISS AMERICA 2014 NINA DAVULURI: WORKING FOR SCIENCE, MEDICINE, ENGINEERING, TECHNOLOGY

In 2013, Nina Davuluri became the first contestant of Indian descent to win the Miss America competition. The Syracuse, N.Y., native was educated at the University of Michigan and plans to attend medical school. During her year as Miss America, Davuluri will serve as spokesperson for increasing enrollment in the STEM fields – Science, Technology, Engineering, and Mathematics – working with the U.S. Department of Education. Along with the coveted title of Miss America 2014, the 24-year-old won a $50,000 scholarship provided in part by Joseph Ribkoff Inc. and the Miss America Organization to continue her education. For the talent portion of the competition, Davuluri returned to her roots and performed a Classical Bollywood Fusion dance.

2014 JULEP BALL ENTERTAINMENT

BOB HARDWICK: BRINGING HIS SOUND HOME TO LOUISVILLE

Growing up in a banking family in Louisville, Hardwick started to play the piano and compose at age four with the gift of perfect pitch. He went on to win numerous national talent competitions including the Coca-Cola Talent Contest and was accepted for private study by the University of Louisville School of Music at age 12. After earning a BA in business from Centre College and completing graduate music studies at the University of North Texas (classical and jazz), he studied composition with Hall Overton at the Juilliard School of Music. He also received a DownBeat magazine award scholarship to Berklee College of Music in Boston. "The Bob Hardwick Sound" is now one of the leading dance orchestras in the country, with an average of over 200 engagements per year in the United States, in addition to England, France, Italy, Ireland and Bermuda and the Caribbean. With Bob's dazzling piano artistry, the orchestra's irresistible beat, and a repertoire that delights all ages, Hardwick's music makes every party a success, including Presidential inaugurals, private parties, benefit galas, corporate events, debutante balls and weddings of all sizes. Recently, Hardwick played for his fifth Inaugural Ball and seventh U.S. president by performing at the prestigious Illinois Presidential Inaugural Ball in Washington, D.C., for President Barack Obama.

J.D. SHELBURNE: KENTUCKY NATIVE WITH HITS ‘FARMBOY’ AND ‘GRANDMA & GARTH’

Country artist J.D. Shelburne grew up on a tobacco farm in Taylorsville, Ky., a tiny town southeast of the Ohio River near Louisville. At age 19, he found a guitar after the death of his grandmother and began learning to play and sing on his own. By his sophomore year of college, he had found a few gigs at some local bars in the Louisville and Lexington areas and developed a fan base that eventually landed him on some of the biggest stages in the business, opening for some of the nation's hottest stars. Eventually, Shelburne was adding original songs into the set mix, in addition to producing songs of his own material. Twelve years later he is soaking up country music, touring cities, building a fan base and celebrating a decade of success playing venues all across the southeast trying to get his big break. Today he’s among the most hardworking and relevant country singers in the business, with the hits “Farmboy” and “Grandma & Garth.” They say Nashville doesn’t work that way anymore – that talented musicians with very few connections don’t stand a chance, but J.D. Shelburne proved that Music City’s engine still runs off talent and persistence. Critics find him credible. Fans pack his shows. Venues strive to book him. There are very few new artists recording songs today about whom that can be said.

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About the James Graham Brown Cancer Center:

The James Graham Brown Cancer Center is a key component of the University of Louisville Health Sciences Center. As part of the region's leading academic, research and teaching health center, the cancer center provides the latest medical advances to patients, often long before they become available in non-teaching settings. The JGBCC is a part of KentuckyOne Health and is affiliated with the Kentucky Cancer Program. It is the only cancer center in the region to use a unified approach to cancer care, with multidisciplinary teams of physicians working together to guide patients through diagnosis, treatment and recovery. For more information, visit our web site, www.browncancercenter.org.

The Julep Ball is sponsored in part by Advanced Cancer Therapeutics, Ashton Advertising, Bob Montgomery Dixie Honda, Boutique Serendipity, The Dahlem Company, Dillards, Enterprise, Headz Salon, Heaven Hill, Hubbuch & Co., InGrid Design, Jaust Consulting Partners, Jefferson County Sheriff’s Office, KentuckyOne Health, Kroger, Louisville Magazine, Maker’s Mark, Millennium: The Takeda Oncology Company, Morgan Stanley, MPI Printing, Nfocus, Old 502 Winery, Power Creative, Tito’s Handmade Vodka, WAKY and WHAS11.

Gregory Barnes, M.D., Ph.D., is the inaugural permanent director of the University of Louisville Autism Center. Barnes comes to UofL from Vanderbilt University. Barnes also will hold the Spafford Ackerly Chair for Child and Adolescent Psychiatry and faculty positions in the departments of Neurology and Pediatrics.

“Dr. Barnes is a national leader in providing care for people who are affected by autism,” said David L. Dunn, M.D., Ph.D., executive vice president for health affairs at UofL. “His emphasis on evidence-based treatment, teamed with his research into potential genetic influences into the development of the disorder, as well as the potential influence in epilepsy, make him a perfect fit for our program.”

In 2008, Barnes was appointed national neurology co-leader for the Autism Treatment Network. In 2012 he was appointed to the external scientific advisory committee for the Preclinical Autism Consortium for Therapeutics (PACT). He also has served as a reviewer for the Autism Speaks special grant program for preclinical translational research and the Autism Speaks translational postdoctoral fellowship grant program.

Barnes, who will hold the academic title of associate professor of neurology and pediatrics, has held academic appointments at Washington University School of Medicine in St. Louis, Harvard Medical School, Duke University Medical School, the University of Kentucky College of Medicine and Vanderbilt School of Medicine.

He earned his bachelor of science degree in molecular biology from Vanderbilt University before earning his doctorate in biochemistry from the University of Kentucky. He also earned his medical degree from UK. He served his pediatric residency at St. Louis Children’s Hospital in affiliation with Washington University School of Medicine. He served as a clinical fellow in pediatrics, neurology and epilepsy at Boston Children’s Hospital and Harvard Medical School. He completed an epilepsy research fellowship from the Duke University Center for the Advanced Study of Epilepsy.

The UofL Autism Center at Kosair Charities, located at 1405 Burnett Ave., offers children, parents and community partners a single source for expert treatment, referral and information. It is a joint effort by the UofL departments of Psychiatry and Behavioral Sciences and Pediatrics and the College of Education and Human Development that will eventually incorporate resources from other university programs. The university-based partnership serves as the focus for collaboration with other community-based autism services and advocacy groups.

Movie and television actress Josie Davis joins “Voice of the Cards” Sean Moth and WHAS11 morning anchor Brooke Katz in emceeing The Julep Ball.

Katz will interview celebrities as they make their red carpet entrances, while Davis and Moth will keep the evening moving as emcees.

The premier Derby Eve Party with a Purpose, The Julep Ball is held annually on the evening before the Kentucky Derby and supports the work of the James Graham Brown Cancer Center at the University of Louisville. The event on May 2 at the KFC Yum! Center kicks off with a 6:30 p.m. cocktail reception, followed by dinner and a live auction at 8 p.m.

An Official Event of the 140^th Kentucky Derby®, The Julep Ball provides a celebrity-studded night to remember with a multi-course seated dinner, a knock-your-socks-off auction, multiple open specialty bars, complimentary valet parking, and dancing until the wee hours of Derby morning. Tickets to The Julep Ball sell out early each year. The full evening’s entertainment is $600 per person, $5,000 for a table of 10, and $100 per person for dance-only tickets. For further information and to buy tickets, go to The Julep Ball website, julepball.org.

About Josie Davis

Josie Davis is best remembered as a series regular on the hit television series Charles in Charge opposite Scott Baio, which she began when she was 12 years old. After the show wrapped, Josie transitioned into series regular roles on Beverly Hills 90210 and then the television series Titans with Victoria Principal.

Davis’ feature film credits include a lead role in Nicholas Cage’s directorial debut Sonny, opposite James Franco and Scott Caan. She also starred in Carolina Moon, opposite Claire Forlani and Oliver Hudson, The Perfect Assistant, Seduced by Lies, and The Perfect Student, Blind Injustice, Past Obsessions, and Dirty Teacher, all for Lifetime.

Davis next can be seen in the indie film Mantervention, coming to theatres in Summer 2014, and also in Stealing Roses opposite John Heard and Wizardream opposite Malcolm McDowell.

Her television credits include a recurring role on CSI: NY and guest starring roles on Two and a Half Men, The Mentalist, Chuck, Bones, Rules of Engagement, Navy NCIS, Burn Notice,Breakout Kings and many more. Josie is a lifetime member of The Actors Studio being run by Martin Landau and Mark Rydell. For more information, visit: www.JosieDavis.com.

About Brooke Katz

Brooke Katz came to WHAS11 and Louisville from her hometown of Charleston, S.C. She anchors the 4:30 a.m. edition of Good Morning Kentuckiana as well as the noon newscast. She also does traffic reports for the 5 a.m. and 6 a.m. shows.

Brooke started her career in journalism at Charleston’s WCBD-TV in 2008, working as a reporter and a producer. On the streets, she covered a wide range of stories from hard news to special health and fitness segments. Since coming to Louisville, Brooke has worked as a multimedia journalist, a general assignments reporter and a feature reporter.

In her spare time, Brooke is an exercise enthusiast. She’s been teaching aerobics classes since her senior year in high school. Brooke received her degree in journalism and media studies and a certificate in criminology from Rutgers University in New Jersey.

About Sean Moth

Enjoying his 15th season at the University of Louisville, Moth has been the “Voice of the Cardinals Athletic Department” during that span as the arena and stadium announcer for the football, volleyball and men’s and women’s basketball teams. In addition, he has been the radio voice of the Louisville Cardinals baseball team for the past 12 seasons.

As associate director of creative services, he works with video and social media and has emceed banquets and events at UofL and around the City of Louisville. The teams he works with have carried him on their coattails to 12 bowl games, five Final Fours and two College World Series.

Moth lives in Louisville with his wife of 20 years, Angie and their 16-year-old son Erik who attends Youth Performing Arts School. When Moth “used to have spare time,” as he phrases it, he enjoyed cooking, good music, fly-fishing and photography.

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About the James Graham Brown Cancer Center:

The James Graham Brown Cancer Center is a key component of the University of Louisville Health Sciences Center. As part of the region's leading academic, research and teaching health center, the cancer center provides the latest medical advances to patients, often long before they become available in non-teaching settings. The JGBCC is a part of KentuckyOne Health and is affiliated with the Kentucky Cancer Program. It is the only cancer center in the region to use a unified approach to cancer care, with multidisciplinary teams of physicians working together to guide patients through diagnosis, treatment and recovery. For more information, visit our web site, www.browncancercenter.org.

The Julep Ball is sponsored in part by Advanced Cancer Therapeutics, Ashton Advertising, Bob Montgomery Dixie Honda, Boutique Serendipity, The Dahlem Company, Dillards, Enterprise, Headz Salon, Heaven Hill, Hubbuch & Co., InGrid Design, Jaust Consulting Partners, Jefferson County Sheriff’s Office, KentuckyOne Health, Kroger, Louisville Magazine, Maker’s Mark, Millennium: The Takeda Oncology Company, Morgan Stanley, MPI Printing, Nfocus, Old 502 Winery, Power Creative, Tito’s Handmade Vodka, WAKY and WHAS11.