News

Tobacco at our public schools

By Brent Troy, M.D., M.P.H., Pediatric Resident Physician

Since the 1980s, we’ve known to protect our children from tobacco’s effects by having a minimum legal age of consumption, but we have failed to protect them from tobacco smoke while they attend public schools or ride a school bus in the state of Kentucky.

About 50 percent of the roughly 650,000 public school students in Kentucky currently attend school in districts that have become smoke free, but the state as a whole has not passed legislation to make our public school facilities smoke free.

While half of the states in this country have enacted laws to keep our children safe from second-hand smoke at school facilities, Kentucky is still working out the kinks of a bill that will pass through the House.

Just a quick search on the CDC website shows what the health care field has known for decades: the countless side effects from second-hand smoke such as asthma attacks requiring admission to the pediatric intensive care unit.  Children who are exposed to smoking are also more likely to smoke themselves, which can lead to breathing problems, increased general health risks and even lung cancer. 

In the emergency department, it is quite common to see children presenting with a severe asthma attack triggered by tobacco smoke.  Seeing the fear in a child’s face, just once, when they can’t get sufficient oxygen, is enough to know something has to be done at a health policy level.  Even those who generally support smaller government and fewer regulations should recognize that protecting vulnerable children is an appropriate role of government.  And while some parents can rest easy knowing their child isn’t exposed to smoke at home, they should have the same level of comfort when their child goes to school or simply rides the school bus.  

As a pediatrician, I have seen far too many cases of second-hand smoke being detrimental to children’s health. I urge you to contact your State Representative and State Senator during this current legislative session, from January to March, to help keep your children out of the hospital, to save money and time for all. 

This pediatrician will be advocating for your children throughout this legislative session and many years to come.

 

 

Coach, provost team up to battle childhood cancer

Head Coach Jeff Walz and Provost Beth Boehm will donate $10 to raiseRED for every student that attends the Louisville women’s basketball game vs. Connecticut.

The University of Louisville announced on Monday that women’s basketball Head Coach Jeff Walz and Provost Beth Boehm have agreed to donate $10 to raiseRED (up to $5,000 each) for every student that attends the Jan. 31 women’s basketball game against Connecticut.

raiseRED is a nationally recognized, student-led philanthropic campaign that fights to end pediatric cancer and blood disease and better the lives of Louisville children and their families.

Students receive a free ticket when they show their ID inside the KFC Yum! Center lobby. Tables will be set up to distribute student tickets on the right-hand side of the lobby.

Doors open at 5:30 p.m. Thursday and the game will tip off at 7 p.m.

“I’m so thrilled to join Dr. Boehm in support of raiseRED. As a leader of student-athletes, it’s exciting to see athletics and academia work in conjunction for such a worthy cause,” said Walz. “I encourage all of our students to join us at the KFC Yum! Center on Thursday night to cheer on our student-athletes and help us raise money for raiseRED.”

“I’m delighted to partner with Coach Walz to help our students raise money to end pediatric cancer,” said Boehm. “I have been a proud supporter of raiseRED since my son was a student here and am so excited to support this cause. Students can attend a great basketball game, support their fellow student-athletes, and contribute to raiseRED. What could be easier?”

“We are so thankful for this partnership,” said Mary Baker, a UofL junior and external project coordinator for raiseRED. “It’s incredible to see athletics and academics coming together to support student organizations like raiseRED, as well as the Louisville community.”

When the No. 4 Cardinals host No. 3 Connecticut on Thursday, it will mark the first time since 2014 that the former conference foes have squared off at the KFC Yum! Center. 

Louisville is averaging 8,823 fans per game this season, which ranks third in the country.

In the past five years, raiseRED has raised over $1.8 million dollars to support the Louisville community. raiseRED’s fundraising culminates in an 18-hour dance marathon that runs from 6 p.m. Feb. 22 until noon Feb. 23.

To donate or learn more, go to raiseRED.org

 

UofL’s McMasters gives moving speech on difference between patient treatment and care

Keynote address given at national conference
UofL’s McMasters gives moving speech on difference between  patient treatment and care

Kelly McMasters, M.D., Ph.D.

In a moving speech on the difference between palliative “treatment” and palliative “care,” the University of Louisville’s Kelly McMasters, M.D., Ph.D., gave the keynote lecture today at the American Society of Clinical Oncology’s Gastrointestinal Cancers Symposium in San Francisco.

McMasters is the Ben A. Reid Sr., M.D., Professor and Chairman of the Department of Surgery at the University of Louisville School of Medicine. He also serves as director of the Multidisciplinary Melanoma Clinic and is associate director of the James Graham Brown Cancer Center at UofL.

In his keynote address, titled “The Fundamental Difference Between Palliative Treatment and Palliative Care,” McMasters noted the audience was filled with those who have devoted their lives to the care of patients with cancer, and will perform research that will relieve suffering, improve quality of life, extend survival and find a cure.

Using one of his patients as an example, he argued that while regular tests and treatments make sense for patients whose cancer can be cured or their lives extended (with good quality), for those with recurring cancer who will eventually die from the disease, there is no evidence early detection of asymptomatic recurrence is any better than waiting until they are symptomatic. For those patients, regular tests and treatments can rob them of their quality of life.

“Our duty to our patients is to care for them, not just for their disease, but for who they are,” McMasters said. “Sometimes, it doesn’t make sense to put the patient through treatments and tests that in the end, won’t affect whether they live or die. They are often better served by living free of pain and suffering, happily in the company of those they love, doing the things that make life worth living.”

McMasters has personal experience in losing a loved one to cancer. He lost his son, Owen, to leukemia.

Also speaking on the topic during the keynote address was Shishir Maithel, M.D., chair of the Winship Cancer Institute at Emory University.

McMasters specializes in melanoma, breast cancer, sarcoma, hepatobiliary tumors and pancreatic and gastric cancers.  At the Brown Cancer Center, he works to identify the most effective combination of treatment including surgery, immunotherapy, targeted therapies, and radiation therapy for patients with all stages of melanoma.

He has been principal investigator or co-investigator of over 30 clinical trials, and president of the Society of Surgical Oncology, the Society of Surgical Chairs, the Western Surgical Association and the Southeastern Surgical Association.  In 2018, he was named editor-in-chief of Annals of Surgical Oncology, and he has authored over 400 peer-reviewed publications and a book.

To hear more from McMasters, see this article on the difference between treatment and care in the Annals of Surgical Oncology: https://bit.ly/2DiZKHk.

For more information about society and the symposium, visit gicasym.org.

The inaugural Richard N. Redinger, M.D. Lectureship

The inaugural Richard N. Redinger, M.D. Lectureship was presented at Medicine Grand Rounds December 13, 2018 by Donald R. Campbell, M.D., FACP, AGAF, University of Missouri-Kansas City.  His topic was “BOGUS or BENEFICIAL? Fecal Transplant for Sepsis, Cancer, Autism, Obesity, Parkinson’s, etc.”

UofL residents post another successful fellowship match

Near-perfection trend in fellowship matches continues for UofL internal medicine residents and junior faculty in 2019
UofL residents post another successful fellowship match

Several members of the of the UofL Internal Medicine Residency Program seeking fellowship appointments were matched successfully for the 2019-2020 academic year.

The fellowship match quest was again successful for several members of the University of Louisville Internal Medicine Residency Program as many found out their future path following their graduation in 2019.

Five of those will continue their career at UofL.

"Our residents have worked very hard to build clinical skills and engage in scholarship in order to successfully pursue subspecialty training," Jennifer Koch, M.D., director of the UofL Internal Medicine Residency Program said. "We are proud to have several of them continue their training at UofL, in addition to matching at multiple other excellent programs across the country!"

Over the past seven years, nearly all of the program's internal medicine residents have successfully matched into their choice of fellowship.

Those from The University of Louisville who matched for 2018-2019 include:

Doctor
Specialty
Institution

Lauren Albers

Gregory Scott Bills

Jorden Burlen

Dafang Chen

Liza Cholin

Praneeth Katrapati

Fahad Khan

Vincent Nguyen

Sanjay Patel

Cristian Rios

Yixi Tu

Benadin Varajic

Dana Williams

Cardiology

Gastroenterology

Gastroenterology

Pulmonary/Critical Care

Nephrology

Cardiology

Rheumatology

Gastroenterology

Allergy

Gastroenterology

Gastroenterology

Pulmonary/Critical Care

Geriatrics

University of Louisville

University of Kentucky

University of Toledo

University of Southern California

Cleveland Clinic

University of Louisville

The Ohio State University

University of Louisville

University of Arizona

University of Louisville

Saint Louis University

University of Louisville

Wake Forest University

Inspiring Curiosity and Restoring Humility

Inspiring Curiosity and Restoring Humility: The Evolution of Competency-Based Continuing Medical Education
McMahon, Graham T., MD, MMSc
This article summarizes the findings from recent studies regarding the association of Maintenance of Certification and physicians’ learning and improvements in care.
CLICK HERE to read the full text.

Pharmacology and Toxicology Graduate Students and Postdocs Receive Awards at National Meetings

Pharmacology and Toxicology PhD candidate Christine Dolin (faculty mentors: Gavin Arteel and Mike Merchant) was selected to present her research in the Best of the Liver Meeting 2018 at the annual meeting of the American Association for the Study of Liver Diseases held Nov 9-13, 2018 in San Francisco, California.
 
Pharmacology and Toxicology graduate students and postdocs received best poster and travel awards at the 10th Conference on Metal Toxicity and Carcinogenesis Oct 28-31, 2018 in Albuquerque New Mexico:

Best Poster Award:

Balaji Chandrasekaran –  faculty mentor: Chendil Damodaran

Travel Awards:

Balaji Chandrasekaran, faculty mentor: Chendil Damodaran
Ana Cardoso, faculty mentor: Christopher States
Jamie Young, faculty mentor: Lu Cai
Christine Kim, faculty mentor: Brian Ceresa

 

Did you know...

Did you know...

The Novak Center for Children’s Health, an $80-million center that opened in downtown Louisville this summer, has been cited among the seven facilities and programs that represent the future of Louisville, according to Insider Louisville.

Prescription for play

Children should have play time every day, according to the American Academy of Pediatrics, which is now urging physicians to talk with families about getting children to play.

“Playing is crucial for learning, stress relief, and brain and skill development,” said Heather Felton, M.D., medical director of the UofL Pediatrics - Sam Swope Kosair Charities Centre. “Developmentally appropriate play with parents and peers is an opportunity to promote social-emotional, cognitive, language and self-regulation skills. It also can be good exercise and supports formation of safe, stable and nurturing relationships.”

Types of play include:

  • Object play (playing with an object and learning about it)
  • Physical, locomotor or rough-and-tumble play
  • Outdoor
    • Social or pretend

How should play be encouraged?

  • It is so important that doctors may even write an actual prescription for play.
  • Doctors should discuss playing, including smiling back at infants and playing peak-a-boo, at every appointment until a child turns 2.
  • Schools should allow for unstructured playtime, as opposed to purely formal teaching, and include daily recess periods.
  • Avoid electronic devices because they encourage passivity and the consumption of others’ creativity rather than active learning and socially interactive play. Plus, they distract from real play.

 

 

UofL Hospital opens newly renovated and expanded Burn Center

Center is currently the only dedicated burn unit in state of Kentucky
UofL Hospital opens newly renovated and expanded Burn Center

Romaine Knight, a firefighter with the Louisville Fire Department’s Engine 5. Knight was a patient at UofL Hospital’s Burn Center in September 2017 after suffering severe burns to his hand.

University of Louisville Hospital has opened its newly renovated and expanded Burn Center, currently the only dedicated burn unit in the state of Kentucky.

Dozens of hospital staff and emergency service workers, including members of the Louisville Fire Department, marked the occasion on Friday with a ribbon-cutting and celebration at the center.

The new Burn Center is on the hospital’s sixth floor, in 6 East, and holds 16 beds. The center was formerly housed on the hospital’s fifth floor, where it held six beds.

“What makes this space so unique is that from start to finish, it was specifically designed just for burn patients,” said Glen Franklin, M.D., a trauma surgeon and a professor in the Department of Surgery at the UofL School of Medicine. “It was made just for them, by the people who take care of them. It’s special. ”

Lori Sipes, clinical nurse manager for the Burn Center, said the renovation marks 35 years of UofL Hospital having a dedicated burn unit. She said the expansion and renovation will help provide even better service to the community and state.

“We are expanding all of our services, from beds to staff to therapy, to offer even better care for patients and their families,” she said. “Everything has been improved and updated, and they have a new state-of-the-art area to be treated in.”

Sipes said the center has 36 critical care nurses and technicians, all of whom have specialized education and training in the care of burn patients and the most up-to-date methods for their care. Its dedicated physical therapist is the only wound specialist in Kentucky dedicated to burns.

Sipes said the center’s brand-new beds are the newest and best surfaces for patients, and each room has its own temperature and humidity control and heat lamps, which she said is important for burn patients as the skin is a primary method of thermoregulation. A new, larger hydrotherapy room with a shower system is also part of the new center.

Even the color palate and interior design is designed to be more soothing for patients and families, she said, with a sitting area in each room, cubbyholes to charge cell phones and dedicated room where families can conference with staff or members can be alone.

Among those in attendance Friday were Louisville Fire Department Chief Greg Frederick and Romaine Knight, a firefighter assigned to Engine 5 downtown at Floyd and Jefferson streets. Knight has firsthand experience in UofL Hospital’s Burn Center as a patient.

On Sept. 20, 2017, he suffered serious burns to his left hand and was admitted to the Burn Center. He was in the center’s intensive care unit for eight days, where he underwent skin grafts to his hand.

“They really have a good team there,” he said. “Everyone was exceptional. They were all so nice, from the nurses, to the technicians, to the plastic surgeons. And they have so much experience, which really helped alleviate my worries. They were able to explain what was happening, and what I could expect - the next day, the next week, the next month, the next year, and even the next couple of years.”

After surgery, he went immediately into physical therapy, which he continued at the UofL Physicians Outpatient Center after he was released from the hospital.

“They did everything they could to ensure I didn’t lose function of my hand, which was vital for me,” he said. “They told me that they would do whatever it took to have the best outcome.”

Today, he said he has virtually normal function of his hand. 

“I really, really appreciate everyone’s service.”

Just before the new Burn Center’s opening, UofL Hospital was re-verified as a Level I Trauma Center by the American College of Surgeons, recognizing its dedication to providing the highest quality of trauma care for all injured patients.  UofL Hospital is one of just two adult Level I Trauma Centers in the state of Kentucky.

DOM members make impact at 2018 Research!Louisville

Annual event highlights, promotes excellence and public awareness of health sciences research at the Louisville Medical Center
DOM members make impact at 2018 Research!Louisville

Smita Ghare, Ph.D., of the UofL Division of Gastroenterology, Hepatology & Nutirtion accepts her 1st place award in the Louisville Chapter - Women in Medicine & Science category at the recent 2018 Research!Louisville


VIEW A PHOTO GALLERY FROM THE 2018 RESEARCH!LOUISVILLE

The University of Louisville Department of Medicine made an impressive showing at the recent 2018 Research!Louisville competitions, held in conjunction with the event's 23rd annual showcase of health/life sciences research conducted at UofL.

A panel of university faculty judges selected the winners of this year's contest from hundreds of entries in the categories of professional/clinical students, basic science grad students, postgraduates and faculty.

Here's a look at finished at or near the top in their respective categories:

Master's Basic Science Graduate Student Award

  • 2nd Place: Aaron Whitt - Paraoxonose 2 plays a critical role in non-small cell lung carcinoma proliferation. Mentor: Chi Li, Ph.D.
  • 1st Place: Steven Gootee - Completing the Death Certificate Accurately: Results from a survey evaluating existing knowledge among practicing physicians. Mentor: Julio Ramirez, Ph.D.

Doctoral Basic Science Graduate Student Award

  • 3rd Place: Anne Geller - The characterization of b-glucan's mechanism of action as an anti-cancer. Mentor: Jun Yan, Ph.D.

Masters Engineering Student Award

  • 3rd Place: Justin Heidel - Cardiomyogenic lineage commitment augments cardiac mesenchymal stromal cell anti-fibrogentic paracrine signaling in vitro. Mentor: Joseph Moore, IV, Ph.D.

Norton Healthcare Medical Student Award

  • 3rd Place: Justin Winkler - Body Composition in Adults with Intellectual and Developmental Disabilities. Mentor: Stephen Winters, M.D.
  • 1st Place: Mallory Zaino - Myocardial infarction regulates prolidase activity and promotes insulin-mediated collagen remodeling in the heart. Mentor: Brad Hill, Ph.D.

Research Associate Award

  • 2nd Place: Min Wang - Aldose reductase is involved in the pathogenesis of alcohol-associated liver disease in mice and patients. Mentor: Swati Joshi-Barve, Ph.D.
  • 1st Place: Sarah Andres - Cancer-selective metal complexes: effects and a novel mechanism of action. Mentor: Paula Bates, Ph.D.

Research Staff Award

  • Winner: Kimberley Buckner - The two Diamond Open Access Journals at the University of Louisville: The University of Louisville Journal of Respiratory  Infections and the Journal of Refugee and Global Health. Mentor: William Mattingly, Ph.D.

Public Health & Information Sciences Master's Student Award

  • Winner: Ugochukwu Owolabi - Missing laboratory values among patients with pneumonia should not exclude them from analysis in clinical research. Mentor: William Mattingly, Ph.D.

Public Health & Information Sciences Doctoral Student Award

  • Winner: Stacey Konkle - Secular Trends in Ambient Volatile Organic Compound Levels, Biomarkers of Exposure and Associations with Cardiometabolic Syndrome: An Analysis of Data from the National Health and Nutrition Examination Survey and the National Monitoring Program. Mentor: Aruni Bhatnagar, Ph.D.

Public Health & Information Sciences Research & Practice in Public Health Award

  • Winner: Connor Glick - Multiple comorbidities among patients with community-acquired pneumonia lead to higher mortality regardless of age. Mentor: William Mattingly, Ph.D.

Jewish Hospital & St. Mary's Foundation Faculty Award in Basic Science

  • Winner: Leila Gobejishvili, Ph.D. - Pathogenic role of PDE4 enzymes in the development of liver fibrosis in humans and mouse models.

Louisville Chapter - Women in Medicine & Science

  • 1st Place: Smita Ghare, Ph.D. - Assessment of sex-based differences in gut-immune interactions in viral-controlled HIV patients

UofL Hospital receives re-verification as a Level I Trauma Center

ULH is one of only two adult Level I Trauma Centers in Kentucky
UofL Hospital receives re-verification as a Level I Trauma Center

A medical transport helicopter takes off from University of Louisville Hospital.

UofL Hospital has been re-verified as a Level I Trauma Center by the American College of Surgeons, recognizing the hospital’s dedication to providing the highest quality of trauma care for all injured patients.  

A team of experienced reviewers in the field of trauma conducted an on-site review of the hospital in July, and the hospital received word of the re-verification this month in an official letter. The verification process provides confirmation the hospital has demonstrated its commitment to providing optimal care.

“The re-verification is acknowledgement of all the hard work that happens here at UofL Hospital every day,” said Kim Denzik, MSN, RN, director of the UofL Hospital Trauma Institute. “There is a tremendous amount of work and preparation that goes into the trauma review. There are a lot of people to be thanked for their continued hard work, diligence and commitment to providing the very best care for our patients.”

The re-verification came from the American College of Surgeons’ Verification Review Committee, an ad hoc committee of the group’s Committee on Trauma.

The Committee on Trauma’s verification program does not designate trauma centers, rather it provides confirmation that a trauma center has demonstrated its commitment to providing the highest quality of trauma care. The actual establishment and designation of a trauma center is the function of local, regional or state agencies. However, verified trauma centers must meet essential criteria that ensure trauma care capability and institutional performance as outlined by the Committee on Trauma.

Having the expert level of care here in Louisville is important to patients like Brandon Clark, who was in a dirt bike accident in March 2017 at age 19.

“I was at my girlfriend’s house racing my brother when the throttle got stuck and I was thrown 53 feet,” Clark said. He was transported from Floyds Knobs, Ind., to UofL Hospital, where he was diagnosed with a broken femur and a separated shoulder. He underwent surgery with an orthopedic specialist at UofL Hospital the next morning.

“It was very rough in the beginning,” Clark said. “I was just 19, and I couldn’t even walk. I left the hospital in a wheelchair. I wanted to give up on life. But nobody there let me give up.”

By August 2018, he was walking again - at the Kentucky State Fair. It was there he ran into a member of the Trauma Center’s staff, Annabelle Pike.

“I wanted to tell her just how great it felt to be walking again. I wouldn’t be here without the staff at UofL Hospital. They work with you a lot. They want to help you out the most.”

Today, he’s going to the University of Northwestern Ohio to be a diesel mechanic, and driving home on weekends to do farming and construction work from his home in Ballardsville, Ky. On Oct. 16, he said he was able to run a mile, just a year and a half after his stay at UofL Hospital.

He said he’s appreciative of the second chance he was given. “It made me realize you can lose your life in the blink of an eye.”

Established by the American College of Surgeons in 1987, the Committee on Trauma’s Consultation/Verification Program for Hospitals promotes the development of trauma centers that provide the entire spectrum of care to address the needs of injured patient, from preventing injuries before they occur, to the hospital resources necessary for trauma care, all the way through the rehabilitation process.

There are five separate categories of verification in the Committee on Trauma’s program: Level I Trauma Center; Level II Trauma Center; Level III Trauma Center; Level I Pediatric Trauma Center; and Level II Pediatric Trauma Center. Each has specific criteria that must be met. UofL Hospital is one of just two adult Level I Trauma Centers in the state of Kentucky, with the other at the University of Kentucky’s Albert B. Chandler Hospital.

Founded in 1913, the American College of Surgeons is a scientific and educational association of surgeons to raise the standards of surgical practice and education and improve the care of the surgical patient. The College is an important advocate for surgical patients and has over 72,000 members, making it the largest association of surgeons in the world.

The College’s Committee on Trauma promotes leadership and cooperation of all participants in a trauma center so injured patients are provided with the best possible care.

Kids with diabetes can enjoy Halloween with parents’ advance planning

Kids with diabetes can enjoy Halloween with parents’ advance planning

Photo: Creative Commons

For many kids, Halloween time is nothing but a big sugar rush. But for children with diabetes, the holiday can be very challenging for the entire family.

Fortunately, kids with diabetes can enjoy the holiday just as much as others, say providers with the Wendy Novak Diabetes Center, a partnership of the University of Louisville and Norton Children’s Hospital.

It just requires a different approach: Parents should plan ahead to work the candy into their child’s diabetes meal plan or ensure they get enough insulin to cover the carbohydrates in the candy.

The Wendy Novak Diabetes Center provides families the following tips on how to enjoy the holiday:

Plan ahead

Sit down with your child in advance to discuss specific Halloween plans so they know what to expect. Involving your child with these plans will more likely increase the chances of them being on board.  

Know your candy

Educate yourself and your child about how certain types of candy can impact their bodies. Some candy like Skittles or Starburst can be used to treat a low blood sugar, but chocolate and other high-fat treats don’t work as well. This also can be used as an opportunity to teach them how to cover carbohydrates with insulin.

Limit pieces of candy per day

Teaching your children moderation is important. Set a rule on how many pieces of candy your child can have in a day, as long as their blood glucose levels aren’t too high. Stick to this plan and apply it to everyone in the house, not just to your child with diabetes.

Divide the candy properly

Divide treats into servings of 15 grams of carbohydrates and bag them individually. This will help keep your child from eating too much at one time.

Prepare activities that don’t involve food

Take the focus off candy. Encourage arts and crafts like pumpkin carving, watching Halloween movies, going on a hayride, or visiting a haunted house.

Select a favorite, trash the rest

Eating all of the candy from trick-or-treating can give a definite sugar high. Pick a treat they can enjoy  throughout the week and get rid of or donate the rest.

‘Make a Trade’ Game:

Let your kids trade pieces of candy for something non-food related, such as a movie ticket, trip to the zoo, new toy, family outing, money, chores, a gift card, etc. This can help redefine the word treat.

For more information, including making appointments with the Wendy Novak Diabetes Center, call 502-588-3400 during business hours and 502-629-6000 after hours and on weekends.

About the Wendy Novak Diabetes Center

Combining specialists from the University of Louisville and Norton Children’s Hospital , the Wendy Novak Diabetes Center works to provide the best possible care for your child. Inpatient care is provided by Norton Children’s Hospital, 231 E. Chestnut St., and outpatient services provided by UofL Physicians staff are available at the UofL Novak Center for Children’s Health, 411 E. Chestnut St. For more information, visit our websites here and here.

UofL Cancer Education Program Award Winners Announced at Research!Louisville

UofL Cancer Education Program Award winners at Research!Louisville:

NCI Cancer Education Program Norbert J. Burzynski Award Professional Student Category


3rd place: Jenci Hawthorne

Assessing the efficacy of the SA-4-1BBL checkpoint stimulator for cancer immunotherapy

Mentors: Haval Shirwan and Esma Yolcu

 

2nd place: Stephen Winter

Evaluation of surface modified nanoparticle transport and metastatic invasion using a novel multicellular ovarian tumor spheroid model.

Mentor: Jill Steinbach-Rankins

 

1st place: Evan Delfino

Radioembolization with Yttrium-90 in Patients with Unresectable Hepatocellular Carcinoma and a Transjugular Intrahepatic Portosystemic Shunt

Mentor: Melissa Potts

  

NCI Cancer Education Program Norbert J. Burzynski Award Undergraduate Student Category


3rd place: Evgeniya Molotkova

Characterization of a first-in-class targeted inhibitor of the RalGDS oncoprotein

Mentor: Geoffrey Clark

  

3rd place: Dara McDougal

Complex Interactions among Toll-Like Receptor Related Sequence Variants and Prostate Cancer Susceptibility among men of African Descent

Mentor: La Creis Kidd

 

2nd place: Alana Gipson

Targeting Breast Cancer Resistance to Palbociclib via Oncolytic Virotherapy

Mentor: Jorge Gomez-Gutierrez

 

1st place: Keegan Curry

The development of hybrid lipid-polymer nanoparticle architectures for the sustained-release of small hydrophilic molecules

Mentor: Jill Steinbach-Rankins


Cancer Education Program Alumni Also Receiving Awards

Doctoral Basic Science Graduate Student Award

2nd place: Douglas Saforo

Tumor microenvironment mimetic culture aids isolation, expansion, and potency of tumor stromal progenitors from primary lung cancer reactions.

Mentors: Leah Siskind and Levi Beverly


Masters Engineering Student Award

3rd place: Justin Heidel

Cardiomyogenic lineage commitment augments cardiac mesenchymal stromal cell anti-fibrogentic paracrine signaling in vitro


School of Dentistry Basic Science Student Award

2nd place: Zachary Fitzsimmonds

Streptococcus gordonii inhibits Porphyromonas gingivalis induced ZEB2 upregulation in TIGK cells through long non-coding RNA ESRG

Mentor: Richard Lamont



Research!Louisville Award Winners 2018

Research!Louisville is an annual celebration of health-related research. Their goals are to generate additional funding for health sciences research, promote excellence in health sciences research, promote public awareness of health sciences research, and promote the Louisville Medical Center. It took place October 8 - 12, 2018 and more information about the event can be found on their website. Four people from the GI Division won awards at this year's event.

Leila Gobejishvili, PhD
Winner, Jewish Hospital & St. Mary’s Foundation Faculty in Basic Science award

Smita Ghare, PhD
1st Place, Louisville Chapter, Women in Medicine and Science award

Min Wang, PhD
2nd Place, Research Associate Award; Mentor: Swati Joshi-Barve, PhD

Barbra Cave, APRN
School of Nursing Graduate Student award

Watch the recording of the entire award show here.

Cancer Research publication authored by Drs. John and Sandy Wise recognized as NIEHS extramural publication of the month

Hexavalent chromium induces permanent and heritable cell changes

NIEHS grantees showed that exposure to hexavalent chromium can lead to changes to genetic information in human lung cells. Hexavalent chromium is a known lung carcinogen, but the mechanism by which it causes cancer is not well understood. In human lung cells exposed to hexavalent chromium, the researchers observed permanent and heritable changes in DNA molecules that carry genetic information, known as chromosomes, as well as problems in DNA repair.

The researchers exposed lung cells to hexavalent chromium for three 24-hour periods, each about a month apart. After each treatment, they seeded cells onto new plates to regrow. Each generation of cells was tested for changes to chromosomes and DNA repair capacity.

The study provided evidence for the first time that hexavalent chromium induced chromosome translocations, or abnormal arrangements of chromosomes. They also found that exposure to hexavalent chromium inhibited DNA repair. Both the chromosome translocations and the DNA repair inhibition persisted after exposure ceased and both were heritable at the cellular level.

According to the authors, these chromosome imbalances likely lead to preferential selection and survival of abnormal cells, which may provide a growth advantage for cancer cells.

CitationWise SS, Aboueissa AE, Martino J, Wise JP Sr. 2018. Hexavalent chromium-induced chromosome instability drives permanent and heritable numerical and structural changes and a DNA repair-deficient phenotype. Cancer Res 78(15):4203−4214.

Dr. La Creis Kidd presents prostate cancer findings at new cancer center in Senegal

Associate professor and UofL’s highest potential chair in cancer research La Creis Renee Kidd was invited to visit and share her research at Senegal Dakar’s new Cancer Center, whose doors will open in December. Dr. Kidd presented her prostate cancer research to an audience that included Dr. Abdoul Aziz Kasse, director of the prospective Cancer Center in Senegal. Kidd’s research, which has spanned 14 years, focuses on the impact of genetic susceptibility markers and miRNAs in prostate cancer, disease progression and health disparities.

 

41 UofL Cancer Education Program Students to Present Their Cancer Research Projects

Forty one students in the 2018 UofL Cancer Education Program will present their research project posters October 9-10 at Research!Louisville.

The students and their research project posters can be accessed online.

UofL and Jewish Hospital Trager Transplant Center achieve 300th Lung Transplant

First lung transplant at Jewish Hospital took place in 1991
UofL and Jewish Hospital Trager Transplant Center achieve 300th Lung Transplant

UofL's Victor van Berkel, M.D., Ph.D., performed the 300th lung transplant at Jewish Hospital.

The Jewish Hospital Trager Transplant Center and the University of Louisville are celebrating an important milestone – the 300thlung transplant performed at the hospital since the lung transplant program began there 27 years ago.

“Three-hundred lung transplants is a significant milestone for Jewish Hospital Transplant Care,” said Chris Jones, M.D., director of the Transplantation Program at Jewish Hospital and chief of the division of Transplant Surgery at University of Louisville Physicians and the UofL School of Medicine. “We recognize the selfless sacrifice of all organ donors, celebrate the improved lives of our organ recipients, and recognize the impact of everyone on the transplant team for their lifesaving and life-changing work.”

The 300th lung transplant was performed Tuesday, Sept. 18, on a 71-year-old man from northern Kentucky who suffered from pulmonary fibrosis. The patient was on the transplant list for two months before undergoing a lung transplant. The surgery was performed by Victor van Berkel, M.D., Ph.D., surgical director of the Lung Transplant Program at Jewish Hospital and chief of Thoracic Surgery at UofL Physicians and the UofL School of Medicine.

“Each year, we are performing more and more lung transplants at Jewish Hospital, and it is exciting to hit this milestone as this momentum continues,” said Dr. van Berkel, “When I first started, we were doing between five to 10 lung transplants a year. Now we are closer to 20 lung transplants a year, and we’re trying to grow that even further.”

The first lung transplant at the hospital took place in 1991, and the first double lung transplant in 1995. Since then, transplantation has seen significant advancements in anti-rejection medications, surgical techniques and other technologies, helping Jewish Hospital achieve one-year survival rates higher than the national average.

In 2017, the Jewish Hospital Trager Transplant Center’s program with UofL became the first transplant program in Kentucky, and only the second program in the region, to begin offering Ex Vivo Lung Perfusion (EVLP). EVLP is a leading-edge technology that allows for an expansion of the Lung Donor Pool that will allow more patients to receive lifesaving lung transplants.  

“The Jewish Hospital and UofL transplant team are helping save lives in our community each day,” said Ronald Waldridge, M.D., president of Jewish Hospital. “The team is one of the leading providers of organ transplantation in the United States, and milestones like the 300th lung transplant remind us how important this work is daily. We’ve come so far since the first lung transplant in 1991, and we’re looking forward to many more lives impacted.”

On Thursday, doctors and lung transplant recipients gathered at the Jewish Hospital Rudd Heart and Lung Center to celebrate the 300th milestone and the many lives that have been saved over the years thanks to lung transplantation. 

“When I first started my training, we used to have a firm age limit of 65. That was the absolute limit for transplantation,” said Allan Ramirez, M.D., medical director of the Lung Transplant Program at Jewish Hospital and a pulmonologist with UofL Physicians and assistant professor at the UofL School of Medicine. “These days, we are extending that age and our oldest recipient got their lungs at age 75, so we are continuing to push the envelope in terms of being able to offer transplants to older patients, and patients who are sicker who we would not have considered doing a transplant on 5 to 10 years ago.”

Dr. Jill Jacobs is among the 300th lung recipients at Jewish Hospital. Jacobs was the 271st recipient, and was also a double lung transplant recipient. Jacobs says she smoked cigarettes for about 40 years, and by the time she stopped, had already developed chronic obstructive pulmonary disease (COPD).  

“I had the transplant in February of 2017,” Jacobs said. “I have been extremely happy and grateful that I had doctors who have given me my life back. They’ve given me a new life, in fact.”

Jacobs said before the transplant, she couldn’t even do simple things, like getting dressed, without being short of breath. She says the Jewish Hospital Trager Transplant Center has helped change her life.

“I can’t tell you how happy I am that I went to Jewish to have this done,” Jacobs said. “It’s a gift nobody can believe. It’s a miracle, in my opinion. A miracle.”

Earlier this year, the Jewish Hospital Trager Transplant Center – a joint program with the UofL Physicians, the UofL School of Medicine and KentuckyOne Health – also celebrated its 500th heart transplant. In addition to Kentucky’s first heart transplant, the program is known for performing Kentucky’s first adult pancreas, heart-lung and liver transplants.

For information on the Jewish Hospital Trager Transplant Center, visit www.kentuckyonehealth.org/transplant-care.

M&I Faculty Receive Multiple Awards in 2018

M&I Endowed Chair Professor Yousef Abu-Kwaik was recently awarded a National Institute of Health R01 grant entitled "Innate immunity and inflammatory response of macrophages to Legionella infection".  The grant received a score of 1%.  This NIH funded project is budgeted from 09/14/2018 - 08/31/2023 for $1,913,286.


M&I Associate Professor Esma Yolcu recently received a SBIR Phase I award from the National Institute of Health entitled “Exploiting activation-induced cell death as a means of inducing tolerance to kidney allografts”.  The award is a collaboration with the University of Wisconsin, Madison.


M&I Associate Professor Esma Yolcu and M&I Professor Haval Shirwan recently received a $500,000 gift in memory of William Marvin Petty, MD.  The funds are to be used to advance Type 1 Diabetes research conducted in the School of Medicine Department of Microbiology and Immunology.  Dr. Yolcu and Dr. Shirwan’s research focuses on the use of ProtEx technology, pioneered by the team, as an alternative to gene therapy for immunomodulation to treat transplant rejection and autoimmune diseases with particular focus on Type 1 Diabetes.     

 

M&I Professor Haval Shirwan received a five year NIH/NIAID R01 grant award in support of the application entitled “A novel immunomodulatory approach to overcome innate and adaptive immune barriers to islet transplantation”.  The project is for the period  11/5/2018 – 10/31/2023 with a total budget of $1,943,360.

 

M&I Associate Professor Bing Li was recently awarded a National Institute of Health R01 grant entitled "Immunomodulatory mechanisms of E-FABP in psoriasis pathogenesis".  This NIH funded project is budgeted from 09/24/2018 - 08/31/2023 for $1,925,000.

 

M&I Associate Professor's Matthew Lawrenz (PI) and Jonathan Warawa (Co-PI) were awarded a contract from the FDA entitled “Development of a Mouse Model for Preclinical Screening of Investigational Drugs Against Pseudomonas Aeruginosa and Acinetobacter Baumannii”.  The $933,606 award runs from 9/19/2018 to 9/18/2020. http://www.uoflnews.com/post/uofltoday/uofl-researchers-escalate-efforts-against-multi-drug-resistant-bacteria-with-fda-contract/

  

Abu-Kwaik

Dr. Abu-Kwaik

Shirwan

Dr. Shirwan

Yolcu

Dr. Yolcu

Bing Li

Dr. Li

Matthew Lawrenz

Dr. Lawrenz

Jonathan Warawa

Dr. Warawa