Srinivas Sithu, Ph.D.

Srinivas Sithu, Ph.D.

Srinivas Sithu, Ph.D.
srinivas.sithu@louisville.edu
Assistant Professor
University of Lucknow, India, 1999


Research: My broad research goal is to understand the molecular mechanisms of inflammatory disease process in order to inhibit progression of the disease. My current studies investigate (1) how arsenic increases atherosclerosis and which mechanisms mediate its cardiotoxicity and, (2) the mechanisms by which lipid derived aldehydes affect atherogenesis and how the effects of these aldehydes could be prevented or therapeutically minimized to decrease atherosclerosis.

Publications:

  1. Vladykovskaya E*, Sithu SD*, Haberzettl P, Wickramasinghe NS, Merchant ML, Hill BG, McCracken J, Agarwal A, Dougherty S, Gordon SA, Schuschke DA, Barski OA, O'Toole T, D'Souza SE, Bhatnagar A, Srivastava S. (2012) Lipid peroxidation product 4-hydroxy-trans-2-nonenal causes endothelial activation by inducing endoplasmic reticulum stress. J Biol Chem. 287(14):11398-409.  (*co-first authors). http://www.ncbi.nlm.nih.gov/pubmed/22228760

  2. Srivastava S, Sithu SD, Vladykovskaya E, Haberzettl P, Hoetker DJ, Siddiqui MA, Conklin DJ, D'Souza SE, Bhatnagar A.  (2011) Oral exposure to acrolein exacerbates atherosclerosis in apoE-null mice. Atherosclerosis. 215(2):301-8. http://www.ncbi.nlm.nih.gov/pubmed/21371710

  3. Sithu SD, Srivastava S, Siddiqui MA, Vladykovskaya E, Riggs DW, Conklin DJ, Haberzettl P, O'Toole TE, Bhatnagar A, D'Souza SE. (2010) Exposure of Acrolein by Inhalation causes Platelet Activation. Toxicol. Appl. Pharmacol. 15;248(2):100-10. http://www.ncbi.nlm.nih.gov/pubmed/20678513

  4. Han S, Arnold SA, Sithu SD, Mahoney ET, Geralds JT, Tran P, Benton RL, Maddie MA, D'Souza SE, Whittemore SR, Hagg T. (2010) Rescuing vasculature with intravenous angiopoietin-1 and alphavbeta3 integrin peptide is protective after spinal cord injury. Brain, 133(4):1026-42. http://www.ncbi.nlm.nih.gov/pubmed/20375135

  5. Srivastava S, Vladykovskaya EN, Haberzettl P, Sithu SD, D'Souza SE, States JC. (2009) Arsenic exacerbates atherosclerotic lesion formation and inflammation in ApoE-/- mice. Toxicol Appl Pharmacol. 241(1):90-100. http://www.ncbi.nlm.nih.gov/pubmed/19682479

  6. Nakashima S, Arnold SA, Mahoney ET, Sithu SD, Zhang YP, D'Souza SE, Shields CB, Hagg T. (2008) Small-molecule protein tyrosine phosphatase inhibition as a neuroprotective treatment after spinal cord injury in adult rats. J Neurosci. 28(29):7293-303. http://www.ncbi.nlm.nih.gov/pubmed/18632933

  7. Essick E, Sithu SD, Dean W, D'Souza S. (2008) Pervanadate-induced shedding of the intercellular adhesion molecule (ICAM)-1 ectodomain is mediated by membrane type-1 matrix metalloproteinase (MT1-MMP). Mol Cell Biochem. 314(1-2):151-9. http://www.ncbi.nlm.nih.gov/pubmed/18454303

  8. Moshal KS, Zeldin DC, Sithu SD, Sen U, Tyagi N, Kumar M, Hughes WM Jr, Metreveli N, Rosenberger DS, Singh M, Vacek TP, Rodriguez WE, Ayotunde A, Tyagi SC. (2008) Cytochrome P450 (CYP) 2J2 gene transfection attenuates MMP-9 via inhibition of NF-kappabeta in hyperhomocysteinemia. J Cell Physiol. 215(3):771-81. http://www.ncbi.nlm.nih.gov/pubmed/18181170

  9. Sithu SD, English WR, Olson P, Krubasik D, Baker AH, Murphy G, D'Souza SE. (2007) Membrane-type 1-matrix metalloproteinase regulates intracellular adhesion molecule-1 (ICAM-1)-mediated monocyte transmigration. J. Biol. Chem. 282(34):25010-9. http://www.ncbi.nlm.nih.gov/pubmed/17591781

  10. Tsakadze NL*, Sithu SD*, Sen U, English WR, Murphy G, D'Souza SE. (2006) Tumor Necrosis Factor-a Converting Enzyme (TACE/ADAM-17) Mediates the Ectodomain cleavage of Intercellular Adhesion Molecule (ICAM-1) J Biol. Chem. 281(6):3157-64. (*co-first authors). http://www.ncbi.nlm.nih.gov/pubmed/16332693

  11. Tsakadze NL, Sen U, Zhao Z, Sithu SD, English WR, D'Souza SE. (2004) Signals mediating cleavage of intercellular adhesion molecule-1. Am. J. Physiol. Cell Physiol. 287(1):C55-63. http://www.ncbi.nlm.nih.gov/pubmed/14973144