Nino Muradashvili, M.D.

Nino Muradashvili, M.D.

Nino Muradashvili, M.D.
n0mura01@louisville.edu
Assistant Professor (Term)
Tbilisi State Medical University, Tbilisi, Georgia, 2002

Our research is focused on mechanisms of changes in vasculo-neuronal unit and the resultant neurodegeneration during cardiovascular and cerebrovascular diseases such as hypertension, diabetes, stroke, Alzheimer’s disease and traumatic brain injury.

Our target is to develop the strategies of treatment of neurovascular disorders using antioxidants, exosomes, siRNAs, stem cells, and vascular fractions (for neovascularization).

Selected Publications:

 

  1. Muradashvili N, Tyagi N, Tyagi R, Munjal C, Lominadze D. Fibrinogen alters mouse brain endothelial cell layer integrity affecting vascular endothelial cadherin. Biochemical and Biophysical Research Communications. 2011; 413(4): 509-514.
  2. Muradashvili N, Qipshidze N, Munjal C, Givvimani S. Benton R, Tyagi, SC, Lominadze D. Fibrinogen-induced increased pial venular permeability in mice. J Cerebral Blood Flow and Metabolism. 2012; 32(1): 150-163.  Cover photo
  3. Muradashvili N, Tyagi R, Lominadze D. A dual-tracer method for differentiating transendothelial transport from paracellular leakage in vivo and in vitro. Frontiers in Vascular Physiology. 2012; 3: 166-172.
  4. Muradashvili N, Lominadze D. Role of fibrinogen in cerebrovascular dysfunction after traumatic brain injury (Review). Brain Injury. 2013; 27(13-14): 1508-1515.
  5. Muradashvili N, Benton RL, Tyagi SC, Lominadze D. Elevated Level of Fibrinogen Increases Caveolae Formation; Role of Matrix Metalloproteinase-9. Cell Biochemistry and Biophysics. 2014; 69(2): 283-294.
  6. Kalani A, Kamat PK, Familtseva A, Chaturvedi P, Muradashvili N, Narayanan N, Tyagi SC, Tyagi N. Role of microRNA29b in Blood-brain barrier dysfunction during Hyperhomocysteinemia: An Epigenetic Mechanism. J Cerebral Blood Flow and Metabolism. 2014; 34(7): 1212-22.
  7. Muradashvili N, Khundmiri SJ, Tyagi R, Gartung A, Dean WL, Lee M, Lominadze D. Sphingolipids affect fibrinogen-induced caveolar transcytosis and cerebrovascular permeability. American Journal of Physiology, Cell Physiology. 2014; 307(2):C169-79.
  8. Muradashvili N, Tyagi R, Metreveli N, Tyagi SC, Lominadze D. Ablation of MMP-9 gene ameliorates paracellular permeability and fibrinogen-amyloid beta complex formation during hyperhomocysteinemia. J Cerebral Blood Flow and Metabolism. 2014; 34(9): 1472-82.
  9. Muradashvili N, Benton RL, Saatman KE, Tyagi SC, Lominadze D. Ablation of matrix metalloproteinase-9 gene decreases cerebrovascular permeability and fibrinogen deposition post traumatic brain injury in mice. Special issue entitled: “Mechanisms and therapies for acute CNS insults”. (Ed.Raghu Vemuganti) Metabolic Brain Disease 2015; 30(2): 411-426.
  10. Amin M, Pushpakumar SB, Muradashvili N, Kundu S, Tyagi SC, Sen U. Regulation and involvement of matrix metalloproteinases in vascular diseases. Special issue, Landmark edition (Ed. Jian Cao), Frontiers in Bioscience, 2016; 21(1): 89-118.