Yiming Huang, M.D.

Yiming Huang, M.D.


Yiming Huang, M.D
Assistant Professor
y0huan01@louisville.edu
Tongji Medical University, 1985

The goal of our projects is to investigate the mechanisms of facilitating cells (FC) action on enhancing engraftment of hematopoietic stem cells (HSC) and induction of tolerance. Facilitating cells (CD8+/TCR-), a novel cell population in bone marrow, enhance engraftment of purified HSC in syngeneic and allogeneic recipients. The subsets of CD8+/TCR- FC include the plasmacytoid precursor dendritic cell (p-preDC) FC, CD19 FC, and NK FC. The majority of FC are p-preDC. Studies underway include characterizing the mechanism of p-preDC FC-mediated tolerance induction and evaluating whether FC function through induction of regulatory T-cells in vivo. Additional studies include evaluating whether FC contribute to diabetes-pathogenesis and/or prevention and evaluating the role of stem cells in tissue regeneration.
Recent Publications

  1. Xu, H., Chilton, P.M., Huang, Y., Schanie, C.L., and Ildstad, S.T.: Production of donor T cells is critical for induction of donor-specific tolerance and maintenance of chimerism. Journal of Immunology 172:1463-1471, 2004.
  2. Huang, Y., Rezzoug, F., Chilton, P.M., Grimes, H.L., Cramer, D.E., and Ildstad, S.T.: MHC at the MHC Class I K locus is essential for long-term engraftment of purified hematopoietic stem cells: a role for host NK cells in regulating HSC engraftment. Blood 104:873-880, 2004.
  3. Chilton, P.M., Rezzoug, F., Fugier-ViVier, I., Weeter, L.A., Xu, H., Huang, Y., Ray, M.B., and Ildstad, S.T.: Flt3 ligand treatment prevents diabetes in NOD mice. Diabetes 53:1995-2002, 2004.
  4. Grimes, H.L., Schanie, C., Huang, Y., Fugier, I., Cramer, D., Rezzoug, F., and Ildstad, S.T.: Graft facilitating cells: evidence for a distinct non-T cell lymphoid lineage. Experimental hematology 32:946-954, 2004.
  5. Huang, Y., Rezzoug, F., Xu, H., Chilton, P.M., Schanie, C., Fugier, I., and Ildstad, S.T.: Natural killer cells play a critical role on regulation of Class I deficient hematopoietic stem cells engraftment: evidence for NK tolerance correlates with receptor editing. Journal of Immunology 175:3753-3761, 2005.
  6. Fugier, I., Rezzoug, F., Huang, Y., Graul-Layman, A.J., Schanie, C.L., Xu, H., Chilton, P.M., and Ildstad, S.T.: Plasmacytoid precursor dendritic cells facilitate allogeneic hematopoietic stem cells engraftment. Journal of Experimental Medicine 201:373-383, 2005.
  7. Chilton, P.M., Rezzoug, F., Ratajczak, M.Z., Vivier-Fugier, I., Ratajczak, J., Kucia, M., Huang, Y., Tanner, M.K., and Ildstad, S.T.: Hematopoietic stem cells from NOD mice exhibit autonomous behavior and a competitive advantage in allogeneic recipients. Blood 105:2189-2197, 2005.
  8. Huang, Y., Kucia, M., Rezzoug, F., Ratajczak, J., Tanner, M.K., Ratajczak, M.Z., Schanie, C.L., Xu, H., and Ildstad, S.T.: FL-mobilized peripheral blood but not FL-expanded bone marrow FC promote establishment of chimerism and tolerance. Stem Cells 24:936-948, 2006.
  9. Dawn, B., Guo, Y., Rezazadeh, A., Huang, Y., Stein, A.B., Hunt, G., Tiwari, S., Prabhu, S.D., Gu, Y., Varma, J., Kajstura, J., Anversa, P., Ildstad, S.T., Bolli, R.: Postinfarct cytokine therapy regenerates cardiac tissue and improves left ventricular function. Circulation Research 98:1098-1105, 2006.
  10. Xu, H., Chilton, P.M., Tanner, M.K, Huang, Y., Schanie, C.L., Dy-Liacco, M., Yan, J., and Ildstad, S.T.: Humoral Immunity is the Dominant Barrier for Allogeneic Bone Marrow Engraftment in Sensitized Recipients. Blood 108:3611-3619, 2006.
  11. Huang, Y., Fugier-Vivier, I.J., Miller, T., Elliott, M.J., Tanner, M.K., Xu, H., Hussain, L.R., Bozulic, L.D., Chilton, P.M., and Ildstad, S.T.: Plasmacytoid precursor dendritic cells from NOD mice exhibit impaired function: are they a component of diabetes pathogenesis? Diabetes, 57:2360-2370, 2008.
  12. Huang, Y., Ratajczak, M.Z., Reca, R., Xu, H., Tanner, M., Rezzoug, F., Hussain, L-R, Fugier-Vivier, I., Bolli, R., and Ildstad, S.T.: Flt3 expression discriminates HSC subpopulations with differing engraftment-potential: identifying the most potent combination. Transplantation, 85:1175-1184, 2008.
  13. Rezzoug, F., Huang, Y., Tanner, M., Wysoczynski, M., Schanie, C.L., Chilton, P.M., Ratajczak, M.Z., Fugier-Vivier, I., and Ildstad, S.T.: TNFa is critical to facilitate hematopoietic stem cell engraftment and function.  Journal of Immunology, 180:49-57, 2008.