Jonathan Freedman, Ph.D.


Department of Pharmacology and Toxicology

Research Tower A 1300 502–852–5348


Ph.D., Molecular Pharmacology, Albert Einstein College of Medicine (1986)

Research Areas and Projects

The research program in our group involves understanding how exposures to environmental toxicants contribute the development and/or exacerbation of human diseases.  Our group is interested in the roles of the transition metals in the etiology of cancer, metabolic disorders (i.e., type II diabetes) and Autism Spectrum Disorder.  In association with other investigators within the University, we are applying a systems biological approach; where interactions among phenotypes, genetics and environmental factors at the molecular, cellular, organ and whole organism level are characterized in an integrated manner.  This holistic approach allows us to develop novel models that delineate the mechanism(s) by which multiple factors come together to produce human disease.  Our groups focus is at the molecular and cellular levels, where we explore the intracellular regulatory processes controlling an organism's response to environmental stress.  By applying classic genetic and reverse-genetic approaches, molecular biology and transcriptomics; regulatory pathways that respond to metals are identified and characterized.  Our group utilizes model organisms (Caenorhabditis elegans and mice) and mammalian cell culture, as well as high throughput screening technologies to explore the environmental contributions to human disease.

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