Paul N. Epstein, Ph.D.

Paul N. Epstein, Ph.D.

Research Biography

Paul N. Epstein, Ph.D.
Professor Pediatrics
McFerran Chair Pediatric Diabetes Research

 

Research Interests

Renal complications of diabetes:  Podocyte injury and podocyte replacement in diabetic nephropathy

Grant Support in the Past 5 Years

Mitochondrial DNA damage in diabetic cardiomyopathy, 7-11-BS-37 American Diabetes Association, 7/1/2011-6/30/2014, (Epstein PI, 10% effort) $95,000 direct costs per year
Defining mechanisms of tubular damage in diabetic kidney,  1-2011-588 Juvenile Diabetes Research Foundation, 8/1/2011-7/30/14 Dave Powell (PI) Epstein 5% effort     Annual direct costs $150,000    
Podocytes and Oxidative Stress in Diabetic Kidney, RO1-DK072032     NIH/NIDDK 9/30/05-7/31/11 with 1 year extension    Paul N Epstein PI    25% effort    $220,000 direct costs per year
Prolonged diabetic damage to cardiac mitochondria, RO1-DK073586 NIH/NIDDK    Paul N Epstein PI 2/15/05-12/31/2010    and  RO1DK073586-04S1    1/1/2010-9/30/10     20% effort     $238,000 direct costs per year and $100,000 supplement final year
Characterization of diabetes effects on purified transgenic podocytes,JDRF Grant Number: 17 2009 723 Paul N Epstein PI  10% effort 9/01/2009-8/30/2010  $100,000 direct costs per year

Education and Training

•    Ph.D. Pharmacology     Baylor College of Medicine, Houston
•    Postdoctoral Fellow,  Departments of Pharmacology and Cell Biology, Baylor College of Medicine, Houston

Recent Publications

Long YS, Zheng S, Kralik PM, Benz FW, Epstein PN. Impaired Albumin Uptake and Processing Promote Albuminuria in OVE26 Diabetic Mice. J Diabetes Res. 2016;2016:8749417.

 Wu H, Kong L, Tan Y, Epstein PN, Zeng J, Gu J, Liang G, Kong M, Chen X, Miao L, Cai L. C66 ameliorates diabetic nephropathy in mice by both upregulating NRF2 function via increase in miR-200a and inhibiting miR-21. Diabetologia. 2016 Jul;59(7):1558-68. doi

 Xu J, Zheng S, Kralik PM, Krishnan L, Huang H, Hoying JB, Cai L, Carlson EC, Tan Y, Epstein PN. Diabetes Induced Changes in Podocyte Morphology and Gene Expression Evaluated Using GFP Transgenic Podocytes.  Int J Biol Sci. 2016 Jan 1;12(2):210-8. 

 Zheng S, Coventry S, Cai L, Powell DW, Jala VR, Haribabu B, Epstein PN. Renal Protection by Genetic Deletion of the Atypical Chemokine Receptor ACKR2 in Diabetic OVE Mice. J Diabetes Res. 2016;2016:5362506. doi:

 Dai X, Yan X, Zeng J, Chen J, Wang Y, Chen J, Li Y, Barati MT, Wintergerst KA, Pan K, Nystoriak MA, Conklin DJ, Rokosh G, Epstein PN, Li X, Tan Y. Elevating CXCR7 Improves Angiogenic Function of EPCs via Akt/GSK-3β/Fyn-Mediated Nrf2 Activation in Diabetic Limb Ischemia.  Circ Res. 2017 Mar 3;120(5):e7-e23

Carlson EC, Chhoun JM, Grove BD, Laturnus DI, Zheng S, Epstein PN, Tan Y. Renoprotection From Diabetic Complications in OVE Transgenic Mice by Endothelial Cell Specific Overexpression of Metallothionein: A TEM Stereological Analysis.  Anat Rec (Hoboken). 2017 Mar;300(3):560-576.