Evelyne Gozal, Ph.D.

Evelyne Gozal, Ph.D.

Research Biography

Evelyne Gozal, Ph.D.
Associate Professor
Pediatrics, Pharmacology/Toxicology

Research Interests

Evelyne Gozal’s research centers on understanding the modulation of hypoxia-induced stress response pathways in neuronal and supporting tissue in diseases such as cerebrovascular disorders, neurodegenerative and pulmonary diseases, sleep apnea, and nervous system injury. All these disorders result in extensive inflammatory response,  oxidative stress and  are accompanied by substantial neurobehavioral morbidity, which is accounted by the excessive neuronal cell loss and glial dysfunction associated with restricted oxygen supply to the neural tissue. Elucidating the mechanisms underlying these pathologies will uncover novel therapeutic strategies interfering with the signaling events triggered in response to intermittent or sustained hypoxia and may prevent delayed injury and improve recovery. Additional projects explore consequences of diabetes on lung microvascular function, oxidative stress-induced signaling pathways in lung injury and mechanisms of preconditioning.

Education/Training

  • Hebrew University of Jerusalem, B.Sc., 1976, Biology
  • Hebrew University of Jerusalem, D.Pharm, 1982, Pharmacy
  • University of Southern California, Ph.D., 1997, Toxicology

 

Recent Publications

Schurr AGozal E  Glycolysis at 75: is it time to tweak the first elucidated metabolic pathway in history?  Front Neurosci. 2015 May 15;9:170.

Jagadapillai R, Rane MJ, Lin X, Roberts AM, Hoyle GW, Cai L, Gozal E. Diabetic Microvascular Disease and Pulmonary Fibrosis: The Contribution of Platelets and Systemic Inflammation.  Int J Mol Sci. 2016 Nov 8;17(11).

Chen SG, Stribinskis V, Rane MJ, Demuth DR, Gozal E, Roberts AM, Jagadapillai R, Liu R, Choe K, Shivakumar B, Son F, Jin S, Kerber R, Adame A, Masliah E, Friedland RP. Exposure to the Functional Bacterial Amyloid Protein Curli Enhances Alpha-Synuclein Aggregation in Aged Fischer 344 Rats and Caenorhabditis elegans.  Sci Rep. 2016 Oct 6;6:34477.

Roberts AM, Jagadapillai R, Vaishnav RA, Friedland RP, Drinovac R, Lin X, Gozal E. Increased pulmonary arteriolar tone associated with lung oxidative stress and nitric oxide in a mouse model of Alzheimer's disease. Physiol Rep. 2016 Sep;4(17).

Gozal E, Miller CJ, Dematteis M, Sachleben LR Jr, Schurr A, Rane MJ.PKA activity exacerbates hypoxia-induced ROS formation and hypoxic injury in PC-12 cells. Toxicol Lett. 2017 Jul 24. pii: S0378-4274(17)31141-4.