About Us

Kosair Charities Pediatric Clinical Research Unit

The Kosair Charities Pediatric Clinical Research Unit (KCPCRU) is the region’s first state-of-the-art clinical facility dedicated solely to conducting inpatient and outpatient pediatric clinical pharmacology studies.The primary mission of the KCPCRU, which opened in May 2002, is three-fold: research (clinical and translational), clinical service, and education/training. Over 1,000 subjects have been enrolled in clinical trials since 2002.

Research practitioner working with a baby and his caregiver.The clinical facilities of the KCPCRU (approximately 4,000 square feet) are located on the second floor of Norton Children’s Hospital. There are three private inpatient rooms dedicated solely for infants, children and adolescents participating in clinical pharmacology and device research studies.The fully-equipped nursing unit has facilities for phlebotomy and urine collection. The unit also contains a specimen processing laboratory, satellite research pharmacy, patient kitchen and playroom equipped with age-appropriate toys, books and games.The KCPCRU also has several core laboratories that support the translational science mission of the center. These include the Bioanalytical and Pharmacogenetics Core Facilities within the Department of Pharmacology and Toxicology and the Proteomics Core Laboratory within the Department of Medicine.


Why join a clinical research study?

There are frequent questions asked about conducting research in children. Children and Clinical Studies is a website that provides parents and children with the information they need to understand clinical research and make informed decisions about participating in a study. It can also assist primary caregivers in answering patients' questions about research as it provided key concepts of pediatric clinical research. The NIH has also created a video about Children and Clinical Studies that you can view here.

If you want to learn more about current or past clinical trials across the United States, please visit www.ClinicalTrials.gov.

And if you want to learn more about pediatric trials, please visit the Pediatric Trials Network  or NIH Clinical Research Trials and You

KCPCRU studies

These studies are conducted by a multi-disciplinary team within the UofL Department of Pediatrics and represent the collaboration and commitment to Pediatric Clinical Pharmacology research among basic and applied scientists within and external to the Department of Pediatrics. Approximately 150 – 200 subjects are enrolled into KCPCRU clinical/translational research trials annually.

Children are being enrolled in genotyping and phenotyping studies to evaluate the effect of genetics on drug metabolizing enzymes and key pathogenic mediators of disease.

We are also studying medication for:

  • Sedation
  • Pain Control
  • Infections
  • Hypertension
  • Septic shock
  • Asthma
  • Platelet inhibition
  • Gastric esophageal reflux (GERD)
  • Post operative nausea/vomiting
  • Juvenile Rheumatoid Arthritis
  • Autism
  • Diabetes