Vaclav Vetvicka, Ph.D.

Vaclav Vetvicka, Ph.D.

Vaclav Vetvicka, Ph.D.
Professor of Pathology & Laboratory Medicine
Director of Research
Vice Chair for Research

Vaclav Vetvicka, Ph.D.

Post-Doctoral Education:
Faculty of Natural Sciences, Prague, Czech Republic Ph.D., Institute of Microbiology, Czech Academy of Sciences, Prague, Czech Republic

Research Interests:
Role of procathepsin D in breast and lung cancer development. Effects of beta glucan as natural immunomodulator.

Selected Publications:
1.  Ohri, S., Vashishta, A., Proctor, M., Fusek, M., Vetvicka, V.: Depletion of procathepsin D gene expression by RNA interference – A potential therapeutic target for breast cancer. Cancer Biology and Therapy, 6: 1081-1087, 2007.

2.  Vetvicka, V., Vetvickova, J., Frank, J., Yvin, J.C.: Enhancing effects of new biological response modifier 1,3 glucan sulfate PS3 on immune reactions. Biomed. Biopharmacotherapy, 23:1-6, 2007.

3.  Benes, P., Vetvicka,V., Fusek, M.: Cathepsin D-many functions of one aspartic protease. Crit. Rev. Oncol. Hematol., 68:12-28, 2008.  

4.  Ohri, S., Vashishta, A., Proctor, M., Fusek, M., Vetvicka, V.: The propeptide of cathepsin D increases proliferation, invasion and metastasis of breast cancer cells. Int. J. Oncol., 32:491-498, 2008.

5.  Krizan, J., Cuchalova, L., Sima, P., Kralickova, M., Madar, J., Vetvicka, V.: Altered distribution of NK and NKT cells in follicular fluid is associated with IVF outcome. J. Reprod. Immunol., 82: 84-88, 2009.

6.  Novak, M., Vetvicka, V.: Glucans as biological response modifiers. Endocr. Metabol. Immune Disorders Drug Targets, 9:67-75, 2009.

7.  Descroix, K., Vetvicka, V., Jamois, F., Yvin, J-C., Ferrières, V.:  Synthesis of oligo-b-(1,3)-glucanyl-b-(1,3)-mannose and their immunostimulating properties. Bioorg. Med. Chem., 18:348-257, 2010.

8.  Vetvicka, V., Saraswat-Ohri, S., Vashishta, A., Descroix, K., Jamois, F., Yvin, J.C., Ferrieres, V.: New 4-deoxy-(1,3)-b-D-glucan-based oligosaccharides and their immunological potential. Carbohydrate Res., 346:2213-2221, 2011.

9.  Vetvicka, V., Fusek, M.: Procathepsin D as a tumor marker, anti-cancer drug or screening agent. Anticancer Agents Med. Chem. 12:172-175, 2012

10. Vetvicka, V., Vetvickova, J.: Combination of glucan, resveratrol, and vitamin C demonstrates strong anti-tumor potential. Anticancer Res. 32: 81-87, 2012.

11. Vetvicka, V., Vetvickova, J.: Glucan-resveratrol-vitamin C combination offers protection against toxic agents. Toxins 4: 1301-1308, 2012.

12. Vetvicka, V., Vashishta, A., Fuentes, M., Baigorri, R., Garcia-Mina, J.M., Yvin, J.-C.: The relative abundance of oxygen alkyl-related groups in aliphatic domains is involved in the main pharmacological-pleiotropic effects of humic acids. J. Med. Food, 16:625-632, 2013.

13. Vetvicka, V., Richter, J., Svozil, V., Rajnohova-Dobiasova, L., Kral, V.: Placebo-driven clinical trials of Transfer Point Glucan #300 in children with chronic respiratory problems: III. Clinical findings. Am. J. Immunol., 9:88-93, 2013.

Selected Books:
1.  Sima, P., Vetvicka, V.: Evolution of Immune Functions, CRC Press, Boca Raton, 1990.
2.  Vetvicka, V., Rihova, B.: (Eds.), Immunological Disorders in Mice, CRC Press, Boca Raton, 1991.
3.  Fornusek, L., Vetvicka, V.: (Eds.), Immune System Accessory Cells, CRC Press, Boca Raton, 1992.
4.  Vetvicka, V., Sima, P., Cooper, E.L., Bilej, M., Rocha, P.: Immunology of Annelids, CRC Press, Boca Raton, 1994.
5.  Fernandez-Botran, R., Vetvicka, V.: Methods in Cellular Immunology, CRC Press, Boca Raton, 1995.
6.  Fusek, M., Vetvicka, V.: Aspartic Proteinases: Physiology and Pathology, CRC Press, Boca Raton, 1995.
7.  Vetvicka, V., Sima, P.: Evolutionary Mechanisms of Defense Reactions, Birkhauser Publishing, Basel, 1998.
8.  Fernandez-Botran, R., Vetvicka, V.: Advanced Methods in Cellular Immunology, CRC Press, Boca Raton, 2000.
9.  Fernandez-Botran, R., Vetvicka, V.: Methods in Cellular Immunology, Second Edition, CRC Press, Boca Raton, 2001.
10. Vetvicka, V.: Beta Glucan: Nature’s Secret, Wells Printing Co., 2009.
11. Vetvicka, V.: Beta Glucan: Nature’s Secret. Second Edition, Wells Printing Co., 2011.
12. Vetvicka, V., Novak, M. (Eds.) Biology and Chemistry of Beta Glucan, Vol. 1,  Bentham Science Publ., 2011.
13. Vetvicka, V., Novak, M. (Eds.) Biology and Chemistry of Beta Glucan, Vol. 2,  Bentham Science Publ., 2013.
14. Vetvicka, V.: -Glucans as Natural Biological Response Modifiers. Nova Scientific, New York, 2013.

Selected Patents and Patent Applications:
1.  Yvin, J.C., Vetvicka, V.: Therapeutical treatment, US Patent # 6,660,722

2.  Yvin; J.C, Panak; E., Vetvicka; V.: Therapeutical combination against cancer US Patent # 7,070,778

3.  Yvin; J.C, Panak; E., Vetvicka; V.: Therapeutical combination against cancer EU Patent # 200500925250

4.  Yvin, J.C., Vetvicka, V.: Chemotherapeutic antineoplastic treatment, Patent Number: 7,671,040

5.  Yvin, J.C., Vetvicka, V.: Chemotherapeutic antineoplastic treatment, EU Patent # 20050065111

6.  Yvin, J.C., Jamois, F., Vetvicka, V.: Therapeutical treatment with oligo-beta-(1,3)-glucans, dryg used in said treatment. EU Patent # 20050065114

7.  Vetvicka, V., Fusek, M.: Method for inhibition of breast tumor growth, US Patent # 5,800,814

8.  Yvin, J.C. Descroix, K., Ferrieres, V., Jamois, F., Laurent, I., Vetvicka, V.: Oligo-beta-(1,3)-glucan-(1,3)-mannose, oligo-beta-(1,3)-glucane-(1,3)-mannitol and derivatives thereof for treating diseases of the immune system, methods for preparing the same and drugs containing them. EU Patent # EP 2102222

9.  Yvin, J.C., Panak, E., Vetvicka, V.: Oligo-beta-(1,3)-glucan and monoclonal antibodies against cancer. EU Patent # EP1684770

10. Yvin, J.C., Jamois, F., Vetvicka, V.: Pharmaceutical composition and therapeutic treatment with oligo-beta-(1,3)-glucans. EU Patent EP1663258

11. Yvin, J.C. Descroix, K., Ferrieres, V., Jamois, F., Laurent, I., Vetvicka, V.: Use of modified oligo-beta-(1,3)-glucans for treating diseases of the immune system, oligo-beta-(1,3)-glucan-(1,3)-mannose, oligo-beta-(1,3)-glucan-mannitol and derivates thereof, methods for preparing them and medicaments containing them. US Patent # 8,367,641

12. Yvin, J.C., Vetvicka, V.: Use of laminarin in the treatment of cancer. EU Patent # EP1448215

13. Vetvicka, V., Fusek, M., Zidkova, J. Systems and methods for diagnosis and prognosis of cancer, Application number: 20110081669

Mailing Address:
Department of Pathology and Laboratory Medicine
University of Louisville
MDR Bldg.
Louisville, KY 40292

Email: Dr. Vaclav Vetvicka
Phone: (502) 852-1612
Fax: (502) 852-1177