Qingsheng Li, Ph.D.

Research Interests

T-cell immunity in the tumor microenvironment and the impact of dietary fiber on lung cancer

We study the role of dysfunctional T-cell immunity in lung carcinogenesis and resistance to immune therapy. Currently, our research combines use of genetically engineered mouse models (murine Kras lung tumor model) and human tumor samples with specific focus on the analysis of tumor-infiltrating T-cells that influence the responsiveness of tumors to immune checkpoint blockade therapy.  A second project focuses on the role of dietary fiber in the development and progression of lung cancer.

Publications

  1. Li Q, Anderson CD, Egilmez NK. Inhaled IL-10 Suppresses Lung Tumorigenesis via Abrogation of Inflammatory Macrophage - Th17 Cell Axis. Li Q, Anderson CD, Egilmez NK. J Immunol. 2018 Sep 26. pii: ji1800141. doi: 10.4049/jimmunol.1800141. PMID:30257887
  2. Li Q, Harden JL, Anderson CD, Egilmez NK. Tolerogenic Phenotype of IFN-gamma-Induced IDO+ Dendritic Cells Is Maintained via an Autocrine IDO-Kynurenine/AhR-IDO Loop. J Immunol. 2016;197(3):962-70. doi: 10.4049/jimmunol.1502615. PubMed PMID: 27316681.
  3. Li Q, Virtuoso LP, Anderson CD, Egilmez NK. Regulatory Rebound in IL-12-Treated Tumors Is Driven by Uncommitted Peripheral Regulatory T Cells. Journal of immunology. 2015;195(3):1293-300. doi: 10.4049/jimmunol.1403078. PubMed PMID: 26085681.
  4. Rao RR, Li Q, Gubbels Bupp MR, Shrikant PA. Transcription factor Foxo1 represses T-bet-mediated effector functions and promotes memory CD8(+) T cell differentiation. Immunity. 2012;36(3):374-87. doi: 10.1016/j.immuni.2012.01.015. PubMed PMID: 22425248; PubMed Central PMCID: PMC3314246.
  5. Li Q, Rao RR, Araki K, Pollizzi K, Odunsi K, Powell JD, Shrikant PA. A central role for mTOR kinase in homeostatic proliferation induced CD8+ T cell memory and tumor immunity. Immunity. 2011;34(4):541-53. doi: 10.1016/j.immuni.2011.04.006. PubMed PMID: 21511183; PubMed Central PMCID: PMC3083826.