Paula M. Chilton, Ph.D.

Paula M. Chilton, Ph.D.

Research Interests

  • Effects of low-toxicity TLR-based adjuvants on T cell differentiation, function and survival
  • Vaccination and the induction of T cell memory

Selected Publications:

PM Chilton, DM Hadel, TT To, TC Mitchell and RP Darveau.  Adjuvant activity of naturally occurring monophosphoryl lipopolysaccharide preparations from mucosa-associated bacteria. Infection and Immunity, 2013; 81:3317-25. doi: 10.1128/IAI.01150-12. PMID: 23798540

PM Chilton, CA Embry and TC Mitchell. Effects of Differences in Lipid A Structure on TLR4 Pro-Inflammatory Signaling and Inflammasome Activation. Frontiers in Immunolology, 2012; 3:154. doi: 10.3389/fimmu.2012.00154.  PMID: 22707952

RP Darveau and PM Chilton. Naturally occurring low biological reactivity lipopolysaccharides as vaccine adjuvants. 
Expert Reviews Vaccines, 2013; 12:707-9. doi: 10.1586/14760584.2013.811181. PMID: 23885813

SK Gandhapudi, PM Chilton and TC Mitchell.  TRIF is required for TLR4 mediated adjuvant effects on T cell clonal expansion.  PLoS One, 2013; 8:e56855. doi: 10.1371/journal.pone.0056855.  PMID: 23457630

PM Chilton, F Rezzoug, M Ratajczak, I Fugier-Vivier, J Ratajczak, M Kucia, Y Huang, MK Tanner and ST Ildstad.  Hematopoietic stem cells from NOD mice exhibit autonomous behavior and a competitive advantage in allogeneic recipients. Blood, 2005; 105:2189-97.  PMID: 15522953.

PM Chilton and TC Mitchell. CD8 T cells require Bcl-3 for maximal gamma interferon production upon secondary exposure to antigen.  Infection and Immunity, 2006; 74: 4180-9.  PMID: 16790793.

S Sengupta, P Jayaraman, PM Chilton, CR Casella and TC Mitchell. Unrestrained GSK-3β activity leads to activated T cell death and can be inhibited by natural adjuvant. Journal of Immunology, 2007; 178:6083-91.  PMID: 17475833

V Mata-Haro, C Cekic, M Martin, PM Chilton, CR Casella and TC Mitchell.. The vaccine adjuvant monophosphoryl Lipid A as a TRIF-biased agonist of TLR4.  Science, 2007; 316:1628-32.PMID: 17569868

M. Mühlbauer, PM Chilton, TC Mitchell and C Jobin.  Impaired Bcl3 up-regulation leads to enhanced LPS-induced IL-23p19 gene expression in IL-10-/-mice. Journal of Biological Chemistry, 2008; 283:14182-9.  PMID: 18375954.